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1.
BackgroundThe Nutrition Societies of Germany, Austria and Switzerland as the joint editors of the ‘D-A-CH reference values for nutrient intake’ have revised the reference values for zinc in July 2019.MethodsFor infants aged 0 to under 4 months, an estimated value was set based on the zinc intake via breast feeding. For all other age groups, the reference values were calculated using the factorial method considering endogenous zinc losses via intestinal losses, urine, faeces, skin and sweat, semen in men and the additional zinc requirements to build up body weight in children and adolescents as well as in pregnant women. Due to the strong influence of phytate intake on zinc absorption, the recommendations for the intake of zinc for adults are derived depending on low (0.5 mmol/day, corresponding to 330 mg/day), moderate (1.0 mmol/day, corresponding to 660 mg/day) and high (1.5 mmol/day, corresponding to 990 mg/day) phytate intake. The reference values for lactating women take into account the zinc loss via breast milk.Results and conclusionFor adults, pregnant and lactating women, the recommended intake values for zinc range from 7 mg/day to 16 mg/day, depending on sex and dietary phytate intake. 相似文献
2.
Body zinc distribution profile during N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats at various levels of dietary zinc intake 总被引:2,自引:0,他引:2
Zinc distribution is apparently altered in breast cancer patients. It is unclear if this apparent zinc redistribution is a
consequence of altered zinc nutrition or tissue-specific response to breast cancer. Our objectives were to assess effects
of N-methyl-N-nitrosourea-treatment and N-methyl-N-nitrosourea-induced mammary tumorigenesis on body zinc-distribution profile in rats and to assess effects of dietary zinc
intake on the body zinc-distribution profile during N-methyl-N-nitrosourea treatment and N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats. Female Sprague-Dawley rats were assigned to zinc-deficient (3 mg/kg diet)
or zinc-adequate (31 mg/kg diet) ad libitum or pair-fed group. Rats were sham treated or N-methyl-N-nitrosourea treated (50 mg/kg body weight; Experiment 1 or 40 mg/kg body weight; Experiment 2) (n=6). In both experiments, the zinc concentration was significantly higher (6–19 times) in mammary tumor than in mammary gland.
Tissue zinc concentration was essentially unaffected by N-methyl-N-nitrosourea treatment and tumor bearing, but was reduced by zinc deficiency in the bone, kidney, and liver. Overall, higher
mammary tumor zinc concentration and absence of zinc redistribution during N-methyl-N-nitrosourea treatment and N-methyl-N-nitrosourea-induced mammary tumorigenesis, regardless of zinc intakes, indicates zinc accumulation in mammary tumors. Because
zinc is essential for growth and cancer is characterized by uncontrolled growth, this zinc accumulation suggests an involvement
of zinc in N-methyl-N-nitrosourea-induced rat mammary tumorigenesis. 相似文献
3.
Zinc deficiency is a health problem in many communities especially among adolescents because of pubertal growth sprout. This
investigation was carried out to determine the epidemiology of zinc deficiency in junior high school students in Tehran City
in 1997. This cross-sectional study was performed on 881 students (452 males and 429 females) with the mean age of 13.2±1.0
yr, who were selected by multistage random sampling method. Plasma, erythrocyte, and hair zinc levels were assayed by flame
atomic absorption spectrophotometry. Anthropometric and demographic characteristics were measured and recorded on a questionnaire.
Dietary intakes were evaluated by a 24-h recall method. Zinc deficiency was defined as having at least two indices from indices
of erythrocyte, plasma, and hair zinc below 10 μg/mL, 100 μg/dL, and 125 μg/g of hair, respectively.
The results showed that zinc deficiency prevalence was 31.1% (confidence interval: 28–34.4%). Zinc deficiency was 65%, 49%,
and 1.3% based on plasma, erythrocyte, and hair zinc levels, respectively. The mean ± SD for plasma, erythrocyte, and hair
zinc concentration, height-for-age, as well as weight-for-age Z scores were 95.2±17.7 μg/dL, 10.3±2.3 μg/mL, 239.4±54.4 μg/g,
−0.40±0.92, and 0.12±0.91, respectively. As for dietary intake compared with the RDA, 50% of the subjects consumed less than
50% of their requirement for zinc RDA based on a 24-h dietary recall. Zinc intake in subjects was 7.5±3.7 μg, that in boys
was higher than in girls. Correlation coefficients between zinc status indices were very weak. There was neither a linear
nor nonlinear relationship between biochemical parameters and nutritional zinc intake. It is concluded that almost one-third
to one-half of the subjects would be considered zinc deficient. 相似文献
4.
Bekheirnia MR Shamshirsaz AA Kamgar M Bouzari N Erfanzadeh G Pourzahedgilani N Tabatabaie SM Abdollah Shamshirsaz A Kimiagar M Ezzati F Larijani B 《Biological trace element research》2004,97(3):215-224
Trace elements have been considered to play critical roles in bone metabolism. This study aims at determining the serum zinc
profile and its association with bone mineral density (BMD) abnormalities in thalassemic patients. In 131 transfusion-dependent
β-thalassemic patients, aged 10–20 yr, serum levels of zinc were measured by flame atomic absorption spectrophotometry (F-AAS).
BMD values at the lumbar (L1–L4) and femoral neck were determined by dual X-ray absorptiometry (DXA). Dietary zinc intake
and daily consumption of calcium were evaluated by a food-frequency questionnaire. Low serum zinc was found in 84.8% (in 44.7%
severely low). Below −2 BMD Z-scores were observed in 68.7% and 17.6% of the patients at the lumbar and femoral regions, respectively.
Female patients with severe zinc deficiency had lower lumbar BMD Z-scores in comparison to the other females (−3.26 vs −2.54).
Serum zinc in females with femoral BMD Z-scores <−2 was significantly lower by 16.4 μg/dL than other females. Our study suggests
that serum levels of zinc can be lowered in the thalassemic patients and partly affect the BMD. 相似文献
5.
Two groups of 16 rats each were fed the same diet with 12.9 ppm Zn. Nine days after each animal was injected with65Zn for assessing fecal zinc of endogenous origin, zinc intake and excretion were determined for a six-day period at the age
of about five (group I) and nine (II) weeks. At mean growth rates of 5.1 and 5.2 g/day, food consumption per gram of gain
was 2.01 g in group I vs 2.86 g in II. Overall, zinc retention amounted to 21 vs 25 μg Zn/g of gain. Apparent absorption averaged
92 vs 74% of Zn intake (132 vs 189 μg/day), while true absorption averaged 98 vs 92%. It was concluded that endogenous fecal
zinc excretion was limited to the indispensable loss (F
em) in group I (7 μg/day), while it exceeded this minimum loss in group II (33 μg/day). True retention, which reflected total
zinc utilization (true absorption times metabolic efficiency), was derived from apparent absorption plusF
em (11 μg/day for group II according to the greater metabolic body size of the rats). It averaged 98% of Zn intake in group
I vs 80% in group II. The mean metabolic efficiency was 100% vs 87%. The conclusion was that these marked differences between
age groups in utilizing the dietary zinc reflected the efficient homeostatic adjustments in absorption and endogenous excretion
of zinc to the respective zinc supply status. 相似文献
6.
《Endocrine practice》2022,28(10):1069-1071
ObjectiveSecondary hyperparathyroidism commonly occurs in the setting of mid-to low-normal serum calcium levels, often in the setting of chronic kidney disease, phosphate loading, vitamin D deficiency, or insufficient calcium intake or absorption. In this article, we report 9 patients who had adequate kidney function (estimated glomerular filtration rate >60 mL/min/1.73 m2) and normal 25-hydroxy vitamin D level (≥30 ng/dL) and whose secondary hyperparathyroidism resolved after starting adequate oral calcium intake.MethodsOur retrospective case series included 8 women and 1 man; the mean age was 69.0 ± 12.2 years (mean ± standard deviation). The initial intact parathyroid hormone (iPTH) level was 80.6 ± 13.4 pg/mL (reference range [ref], 10-65 pg/mL), corrected serum calcium level was 9.2 ± 0.2 mg/dL (ref, 8.5-10.5 mg/dL), serum phosphate level was 3.6 ± 0.4 mg/dL (ref, 2.5-4.9 mg/dL), 25-hydroxy vitamin D level was 42.2 ± 10.5 mg/dL (ref, 20-50 ng/mL), and estimated glomerular filtration rate was 72.6 ± 14.4 mL/min/1.73 m2. Patients were treated clinically with oral calcium 600 mg twice a day.ResultsiPTH was retested after a mean duration of 17.6 ± 12.7 days of calcium supplementation; the iPTH level decreased to 51.0 ± 10.6 pg/mL, with all patients achieving iPTH in the normal range with normocalcemia, consistent with hyperparathyroidism being because of insufficient calcium intake or absorption. All patients were normocalcemic after supplementation.ConclusionSecondary hyperparathyroidism can result from insufficient oral calcium intake. Calcium challenge is an efficacious and cost-effective tool for confirming and treating secondary hyperparathyroidism in the setting of normal vitamin D levels and kidney function. 相似文献
7.
Hee Y. Paik Hyojee Joung Joo Y. Lee Hong K. Lee Janet C. King Carl L. Keen 《Biological trace element research》1999,69(1):45-57
The present study focused on whether serum extracellular superoxide dimutase (EC-SOD) activity can be used as a functional
indicator of marginal zinc deficiency in humans. Subjects in this study were 444 healthy adults over 30 yr of age living a
normal rural life in Kyunggi province, Korea. The mean dietary zinc intake of subjects obtained from one 24-h recall was 6.41
± 4.35 mg and the average serum zinc concentration of the subjects was 11.06 ± 2.44 (μmol/L. Subjects were divided into three
groups by serum zinc concentrations: adequate (serum zinc >10.7 (μmol/L), low (serum zinc 9.0–10.7 μmol/L), and very low (serum
zinc <9.0 μmol/L) groups. A total of 50 subjects were selected from the three groups for analysis of EC-SOD activities. The
EC-SOD activity of subjects increased with increasing serum zinc concentrations, and the activities of the three groups were
significantly different as indicated by the Kruskal-Wallis test (p = 0.0239). Also, serum EC-SOD activities were significantly
correlated with serum zinc concentrations (r = 0.289,p = 0.04). Serum EC-SOD activities, however, were not significantly correlated to the dietary zinc intakes. In conclusion,
these results show that EC-SOD activities are decreased in subjects with low serum zinc concentrations and suggest that EC-SOD
activity may be a functional indicator of zinc nutritional status in humans. 相似文献
8.
Muhittin Onderci Nurhan Sahin Kazim Sahin Nermin Kilic 《Biological trace element research》2003,92(2):139-149
The effects of chromium (chromium picolinate, CrPic) and zinc (ZnSO4H2O) supplementation on serum concentrations of malondialdehyde (MDA) (an indicator of lipid peroxidation) and serum status
of some antioxidant vitamins and minerals of laying hens (Hy-Line) reared at a low ambient temperature (6.8°C) were evaluated.
One hundred twenty laying hens (Hy-Line; 32 wk old) were divided into 4 groups, 30 hens per group. The hens were fed either
a basal diet or the basal diet supplemented with either 0.4 mg Cr/kg of diet, 30 mg Zn/kg of diet, or 0.4 mg Cr plus 30 mg
Zn/kg of diet. Digestibility of nutrients (dry matter [DM], organic matter [OM], crude protein [CP], and ether extract [EE])
increased by supplementation of chromium and zinc (p<0.05). Supplemental chromium and zinc increased serum vitamins C and E but decreased MDA concentrations (p<0.05). Additionally, supplemental chromium and zinc caused an increase in the serum concentrations of Fe, Zn, Mn, and Cr
(p < 0.05). The present study showed that low ambient temperature causes detrimental effects on the digestibility of nutrients
and antioxidant status and that such detrimental effects caused by low ambient temperature can be alleviated by chromium and
zinc supplementation, particularly when Cr and Zn were simultaneously included into the diet. Data obtained in the present
study suggest that such supplementation can be considered as a protective management practice in a diet of laying hens for
alleviating negative effects of cold stress. 相似文献
9.
Numerous studies have shown that zinc nutrition influences the growth of several types of tumor. However, the influence of
zinc nutrition on mammary tumorigenesis is not known. To study the effects of dietary zinc intake on N-methyl-N-nitrosourea (MNU)-induced mammary tumorigenesis, female Sprague-Dawley rats were fed an egg-white-based diet providing 3
(Z3), 12 (Z12), or 31 (Z31) mg zinc/kg diet ad libitum. In addition, two pair-fed controls, PFZ12 and PFZ31, were also included. Fourteen weeks after MNU injection, cumulative
tumor incidence and total number of tumors were lower in Z3 rats than in Z12 and Z31 rats. Cumulative tumor incidence and
total number of tumors were lower in Z3 rats than in PFZ12 rats, but were the same as in PFZ31 rats. Cumulative tumor incidence
and total number of tumors were also lower in pair-fed controls than in their corresponding ad libitum controls, but were the same between the ad libitum controls. Overall, the results showed that the effect of marginal zinc deficiency on MNU-induced mammary tumorigenesis in
rats was primarily the result of a reduced feed intake associated with marginal zinc deficiency rather than zinc per se. 相似文献
10.
Sriwatana Songchitsomboon Surat Komindr Noppawam Plaseu 《Biological trace element research》1998,61(1):97-104
The levels of intake and food sources of zinc and copper in 231 20–80 yr old healthy adults living in Bangkok and surrounding
districts were determined. Dietary data from 3-d food records collected and validated at Research Center, Ramathibodi Hospital
were analyzed. Levels of zinc and copper intake were compared between sexes and age groups (20–39, 40–59, and 60–80 yr). Mean
daily zinc and copper intakes (±SEM) in men were 6.3 ±0.2 and 1.9 ±0.1 mg, respectively. Mean daily zinc and copper intakes
(±SEM) estimated in women (5.5 ±0.2 and 1.6 +-0.1 mg) were significantly lower. Higher zinc and copper intakes were found
in the younger (20-39 yr) age group of both sexes. This could be explained by higher density and percentage from animal source
of both nutrients. Consumption of various types of meat, fish, egg, and milk accounted for 42 and 22%, and rice, the staple
food of Thai people for 9 and 23% of total dietary zinc and copper, respectively. 相似文献
11.
Yasmin H. Neggers Robert L. Goldemberg Suzzane P. Cliver Rachel L. Copper 《Biological trace element research》1998,64(1-3):221-228
A prospective study was conducted to evaluate and compare the determinants of dietary zinc intake in black and white low-income
pregnant women. The study population consisted of 1298 low-income women (70% Black, 30% White) who received prenatal care
at University Hospital at the University of Alabama in Birmingham from 1985 to 1989. Various maternal characteristics were
evaluated at the first prenatal visit. Two 24 h recalls were obtained at 18 and 30 wk of gestation to calculate the intakes
of dietary zinc and other nutrients. Student’st test, ξ2, Pearson correlation coefficients, and multiple regression analyses were used to compare and evaluate the determinants of
zinc and other nutrient intakes in Black and White subjects. The mean prepregnancy body mass index and the mean intake of
zinc, energy, and all the other nutrients except calcium were significantly higher in Black than in White subjects. There
was a significant correlation between zinc and energy intake (r- 0.69,p = 0.001). Age, marital status, parity, socioeconomic status, smoking, and alcohol intake were not significant predictors of
zinc or other nutrient intakes. After adjusting for energy intake, race was the only significant predictor of dietary zinc
intake. Race and energy intake explained 24% of the variation in zinc intake. Results of this study indicate that after adjusting
for other covariates, race and energy intakes are the only predictors of zinc intake in low-income pregnant women. 相似文献
12.
Mika Nishiuchi Kumiko Sakai Hiroyuki Tajima Kazuo Katayama Fumiko Kimura Seiko Hoshi 《Bioscience, biotechnology, and biochemistry》2013,77(12):2168-2175
ABSTRACTWe previously reported an orexigenic action of oral zinc administration in male Sprague-Dawley (SD) rats during an early stage of feeding with a zinc-deficient diet, without decreased zinc concentrations in tissues. The overall conclusion was that orally but not intraperitoneally administered zinc stimulates food intake in short-term zinc-deficient-diet fed rats. We here investigate the mechanism of the orexigenic action of zinc using GC-MS/MS-targeted metabolomic analysis in the rat hypothalamus. Four-week-old, male SD/Slc rats were used, and after 2 days of feeding with a zinc-deficient diet, 3 mg of ZnSO4 in 5 mL saline solution were administered to each rat either orally or intraperitoneally. Three hours after administration, the rats were sacrificed and the hypothalamus were excised and analyzed. We found that the oral administration group showed increased concentrations of 3-aminopropanoic acid (β-alanine), hypotaurine, dopamine, and biotin. In light of metabolomic analysis of these results, we indicate directions for further research. 相似文献
13.
IntroductionZinc is an essential trace element having manifold functions within living cells. Zinc deficiency but also zinc excess impairs cell-specific functions whereas a balanced zinc level is required for an adequate cell behavior.Material and methodsThis study deals with the impact of cellular priming due to stimulation with interleukin (IL)-1, IL-2, IL-4, IL-6 or the chemokine CXCL12a and its subsequent influence on the intracellular free zinc concentration. Since cellular priming and activation is essential for proper immunological reactions, and across that highly cell-type specific, we investigated T cells, B cells, and peripheral blood mononuclear cells (PBMCs). Additionally, alterations of the intracellular zinc content was investigated by inducing zinc deficiency using the zinc chelator N,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diamine (TPEN) with subsequent re-supplementation of zinc, hence generating an intracellular zinc flux. Evaluation of zinc staining with FluoZin3-AM, Zinpyr-1 and Zinquin was done by flow cytometry or by fluorescence microscopy.ResultsOur results indicate that cellular priming for different periods of time (10 minutes/one hour) causes decreased intracellular free zinc concentrations in the FluoZin3-AM staining and increased zinc concentrations stained with Zinpyr-1. Furthermore, zinc supplementation after induced zinc deficiency leads to a fast and excessive rise of the intracellular free zinc levels in most cellular compartments.ConclusionOur study emphasizes the importance of zinc homeostasis and zinc distribution during cellular priming and for certain signaling cascades especially in T and B cells. Moreover, we demonstrated that zinc re-supplementation of zinc deficient cells results in significantly elevated intracellular free zinc concentrations compared to untreated controls. Hence, this underlines the need of a balanced zinc homeostasis for proper immune cell function. 相似文献
14.
Background
The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in SLC30A8 is associated with an increased risk of type 2 diabetes (T2D). We hypothesized that the association between zinc intake and T2D may be modified by the SLC30A8 genotype.Results
We carried out a prospective study among subjects with no history cardio-metabolic diseases in the Malmö Diet and Cancer Study cohort (N = 26,132, 38% men; 86% with genotype data). Zinc intake was assessed using a diet questionnaire and food record. During a median follow-up of 19 years, 3676 T2D cases occurred. A BMI-stratified Cox proportional hazards regression model with attained age as the time scale was used to model the association between total and dietary zinc intake, zinc supplement use, zinc to iron ratio, and risk of T2D adjusting for putative confounding factors.The median total zinc intake was 11.4 mg/day, and the median dietary zinc intake was 10.7 mg/day. Zinc supplement users (17%) had a median total zinc intake of 22.4 mg/day. Dietary zinc intake was associated with increased risk of T2D (P trend < 0.0001). In contrast, we observed a lower risk of T2D among zinc supplement users (HR = 0.79, 95% CI 0.70–0.89). The SLC30A8 CC genotype was associated with a higher risk of T2D (HR = 1.16, 95% CI 1.07–1.24), and the effect was stronger among subjects with higher BMI (P interaction = 0.007). We observed no significant modification of the zinc-T2D associations by SLC30A8 genotype. However, a three-way interaction between SLC30A8 genotype, BMI, and zinc to iron ratio was observed (P interaction = 0.007). A high zinc to iron ratio conferred a protective associated effect on T2D risk among obese subjects, and the effect was significantly more pronounced among T-allele carriers.Conclusions
Zinc supplementation and a high zinc to iron intake ratio may lower the risk of T2D, but these associations could be modified by obesity and the SLC30A8 genotype. The findings implicate that when considering zinc supplementation for T2D prevention, both obesity status and SLC30A8 genotype may need to be accounted for.15.
Monitoring levels of mineral concentrations in animal tissues is important for assessing the effect of contamination on animal
health and safety of animal origin products in human nutrition. This study evaluated the levels of certain trace elements
(copper, zinc, iron, and manganese) in cattle from an industrial and mining region in the north of Spain (Asturias). Samples
of 312 animals aged 9–12 mo were collected from the whole region and analyzed after acid digestion using atomic absorption
spectrophotometry (AAS). The geometric mean concentrations obtained per wet weight for the liver, kidney, muscle, and blood
were 34.3 mg/kg, 4.04 mg/kg, 1.65 mg/kg, and 0.651 mg/L for copper, respectively, and 38.5 mg/kg, 23.0 mg/kg, 47.0 mg/kg,
and 2.44 mg/L for zinc, respectively. For iron, blood was not analyzed and results were 96.2 mg/kg, 105 mg/kg, and 56.0 mg/kg
for the liver, kidney and muscle, respectively. For manganese, only the liver and kidney were analyzed, and the results were
3.11 mg/kg and 1.19 mg/kg, respectively. There was no evidence of an accumulation of toxic levels of trace metals in Asturian
cattle. Females accumulated more iron in the liver (p<0.001, F
1,310=18.4) and the kidney (p<0.001, F
1,310=13.5) and more manganese in the liver (p<0.01, F
1,310=9.55) than males. 相似文献
16.
The concentrations of zinc and copper in gastric juice of humans who had widely varying dietary zinc intake were evaluated.
In order to compare this with zinc and copper levels of normal dietary individuals, we also determined the zinc and copper
levels in healthy individuals' plasma and in cancer patient's natural tissue, all of whom had normal diets. The correlation
coefficients between zinc and copper were 0.71, 0.45, and 0.55, respectively, in gastric juice, plasma, and tissue of normal
dietary subjects. Such correlation changed and was destroyed when there was a high zinc level in gastric juice. When gastric
juice zinc level changed from mean value 16.8 μmol/L to 262.5 μmol/L, the correlation coefficient varied from 0.71 to −0.04,
and the copper level also varied from mean value 8.96 μmol/L to 4.89 μmol/L. These findings probably give the evidence to
suggest that a high zinc level will restrain the copper level and break the balance of the human body's zinc and copper metabolism. 相似文献
17.
Judith R. Turnlund Leslie Wada Janet C. King William R. Keyes Lorra L. Acord 《Biological trace element research》1988,17(1):31-41
Copper absorption was measured at two levels of dietary zinc in six healthy young men who were confined to a metabolic unit
for a 75 d study of zinc utilization. A diet of conventional foods was fed, providing either 16.5 or 5.5 mg zinc and 1.3 mg
copper daily. Copper absorption was determined by feeding65Cu, a stable isotope of copper, once during the 16.5 mg Zn diet and near the beginning and end of the 5.5 mg Zn diet. Apparent
copper absorption averaged 48.1% when the 16.5 mg Zn diet was fed. This was significantly higher than the averages of 37.2
and 38.5% when the 5.5 mg Zn diet was fed. Absorption also differed significantly among subjects. Fecal copper did not differ
between diets or among subjects. All subjects were in positive copper balance at both levels of dietary zinc. These results
suggest that a dietary zinc intake slightly above the Recommended Dietary Allowance of 15 mg/d does not increase fecal copper
loss and does not interfere with copper absorption. 相似文献
18.
《Journal of trace elements in medicine and biology》2014,28(3):293-297
ObjectiveTo assess the influence of zinc serum status on the prevalence of wheezing in a sample of children and adolescents in Northeastern Brazil.Research methods and proceduresThis is a cross-sectional study which included 592 students of 6–12 years old, from the public elementary schools of São Francisco do Conde, Bahia, Northeastern Brazil. Report of wheezing in the past 12 months was collected using a questionnaire of the International Study of Asthma and Allergies in Childhood Program (ISAAC) phase III, adapted to Portuguese. The determination of serum Zn levels was performed using a flame atomic absorption spectrometer. Data on anthropometric status, level of physical activity, pubertal development and socioeconomic information, for each participant were obtained. Multivariate logistic regression analyses were used to assess the associations of interest.ResultsOf the students, 8.6% (95% CI 6.30–10.9) reported having wheezing. The mean (SD) serum zinc level was 114 (22.9 μg/dL). The results of the multiple logistic regression analysis showed, after adjustments, positive and significant association between low serum zinc levels and wheezing. Students categorized as being below the median for serum Zn concentration presented an almost 1.9-fold increase in the wheezing prevalence ratio (OR = 1.9; 95% CI 1.03–3.53).ConclusionThe main findings of this study suggest that the level of zinc may influence the risk of wheezing in late childhood on the study population. 相似文献
19.
Carmiña L. Vargas Zapata Tania M. R. Simões Carmen M. Donangelo 《Biological trace element research》1997,57(2):115-124
Erythrocyte metallothionein (E-MT) is considered a promising index of zinc status in humans, since it may be more sensitive
than other biochemical indices to changes in dietary zinc. However, conditions of high zinc demand with substantial redistribution
of tissue zinc and specific changes in hormone profile, such as pregnancy, may have an influence on E-MT levels in addition
to dietary zinc. In this study, we compared E-MT concentrations in relation to other biochemical zinc indices in healthy pregnant
women at delivery (n=40) and nonpregnant women (n=22) with similar habitual dietary zinc intakes (average 13.3 mg/d). Pregnant women had lower serum zinc and albumin-bound
serum zinc, but higher levels of {ie115-1}-macroglobulin-bound serum zinc than the nonpregnant women. Erythrocyte zinc (E-Zn)
was similar in both groups, but E-MT (mean±SE) was slightly but significantly (p<0.05) higher in the pregnant women (2.9±0.09 nmol/g protein) compared to nonpregnant women (2.6±0.06 nmol/g protein). A significant
correlation was observed between E-MT and E-Zn in the nonpregnant women (r=0.70;p<0.001), consistent with the role of intracellular zinc in the regulation of metallothionein synthesis. However, such correlation
was not observed in the pregnant women, suggesting that E-MT levels in pregnancy may be influenced by factors related to the
pregnant state. 相似文献
20.
BackgroundThe menopausal period is characterized by hormonal imbalance related to the alteration of parameters involved in lipid metabolism. In addition, menopause increases the risk of deficiencies of key vitamins and minerals such as vitamin D and zinc in such women. The present study investigates the influence of zinc supplementation on the status of vitamin D3 and other lipid parameters in postmenopausal women.MethodsFifty-one healthy postmenopausal women aged 44–76 years from the province of Granada (Spain) were divided into two groups (placebo and zinc) of 25 and 26 women, respectively. The zinc group was supplemented with 50 mg/day of zinc for 8 weeks. Nutrient intake assessment was performed by means of a 24 -h reminder. Zinc was determined by flame atomic absorption spectrophotometry. Vitamin D was analyzed by liquid chromatography - tandem mass spectrometry. Leptin was determined by enzyme immunoassay.ResultsZinc supplementation improved the initial vitamin D3 status of the postmenopausal population (p = 0.049). Plasma levels of 25−OH-D3 increased significantly after Zn supplementation in women with lower age at menopause (p = 0.045). Both intake and plasma zinc levels were inversely correlated to serum leptin levels (p = 0.044 and p = 0.033, respectively), being significantly lower in lower age at menopause (p < 0.001).ConclusionZinc supplementation improved vitamin D3 status and was associated to low leptin levels in the postmenopausal women of the study. 相似文献