我想邂逅一只獾

<正>当窗外猫头鹰的"咕咕"声和外公的呼噜声配成一首滑稽的奏鸣曲,我知道,夜已经很深了。穿好衣服,提上鞋子,我蹑手蹑脚地溜出家门。今晚,对,趁着夜深人静,我要独自走入森林,找到外公提到过的那棵老橡树。哪怕田鼠啃咬我的脚趾,虫虫钻进我的衣领,我都会在树下屏住呼吸,耐心守候,因为……     

森林捕狼计中计

爱尔兰多尼戈尔郡郊外,一座名叫贝利的宏伟庄园内。庄园主帕克先生站在巨大的落地玻璃窗前,用食指和大拇指轻轻捏着餐巾一角,优雅从容地抹掉嘴边的一丁点儿花生酱。我的庄园怎么样?尊敬的朱莉小姐!帕克转过身,对身边一位戴着鸟羽装饰帽,衣着华贵的漂亮女士说道。恕我直言,帕克先生。朱莉耸耸肩,您的庄园很美,有花草,有庭院,有骏马,有天鹅,但依我看,它太过柔美了。我听说,在都柏林,时髦的绅士们喜欢给自己的庄园加些野性力量。您知道,温克     

十二生肖(十二属种)动物与人类进化论——人类起源的探索(三)

地球上十二属种动物与人类的关系存在决定意识,人们的社会存在决定人们的社会(思想)意识。人类产生“十二兽”观念并制订,实行十二兽历法,正是人类自身起源于“十二兽”的先祖这一客观事实在人们头脑中的反映。十二兽:我国又称十二禽,十二属,十二物,十二生肖等。所谓十二兽,我国汉族是指鼠,牛,虎,兔,龙,蛇,马,羊,猴,鸡,狗,猪。让我们从十二兽历法的产生和起源来探讨地球上十二属种动物(十二兽)的先祖与人类进化的关系。世界上四大文明古国———中国、印度、埃及和巴比伦各有其“十二兽历法”,内容上大同小异。中国汉族:鼠,牛,虎,兔,龙,蛇,…     

魔鬼熊不是坏家伙

无聊的寒假,无聊的阿拉斯加,没有电子游戏,没有小伙伴,最讨厌的是……阿,阿嚏!这鬼天气简直要把人冻成冰棍。一下飞机,盖瑞就在心里一个劲儿地抱怨。为了写一本关于鹰的书,盖瑞的作家老妈带着他,哦不,应该是硬拽着他来到了偏远的阿拉斯加,美其名曰:在冰天雪地中亲近自然。     

走进内蒙

2015年8月1日,我们每一个人收拾好行囊,整装待发,在邓涛老师带领下踏上了去往内蒙古的征程,拉开了探索灰色生命之旅的序幕. 队伍由两辆车、8人组成,我们早晨7点从中国科学院古脊椎动物与古人类研究所出发,披着清晨的阳光,摆脱城市的拥挤,缓缓地“逃离”了北京城.直到抵达张北之后我们的车子才能像矫健的马儿一样驰骋在广袤的公路上,沿途没有了城市的喧闹,没有了交通的堵塞,伴随我们的只有那一眼望去蓝蓝的天空、随风摆动的小草,以及那迷人的风景,偶尔打开车窗,一股凉爽的清风扑面而来,沁人心脾.经过一路的颠簸,我们在傍晚时刻到达锡林浩特,当地文物保护站的同志为我们安顿好了一切.     

广西容县84例狂犬病流行病学分析及预防对策

目的 通过对容县2000～2007年84例狂犬病流行病学特点进行分析,探讨流行回升的因素,分析目前防治过程中存在的问题,提出狂犬病的预防对策和措施.方法 收集2000～2007年容县狂犬病疫情报告资料及对狂犬病病例的个案调查资料进行分析.结果 近年来,容县狂犬病疫情明显上升,成为有史以来流行高峰,最高年发病率3.04/10万.发病以农民,学生为主,男性多于女性,全年均有病例发生,无明显季节性,狂犬病暴露动物以犬伤为主,暴露部位以头颈部为最危险,潜伏期最短.结论 为有效预防狂犬病流行,应进一步建立完善犬类的管理的法律、法规,使预防狂犬病进入法制轨道,以有效控制狂犬病流行.伤后未能及时正确处理,暴露后免疫率低,是狂犬病发生的重要原因.加强宣传,提高狂犬病的防控知识,政府部门齐抓共管,采取综合性防控措施,才能有效控制狂犬病的流行.     

生物柴油植物桉树类叶油的开发利用

按树是我国南方地区常见的常绿树种,我们经过较长时间的调研和资料整理,认为桉树类的枝叶油与柴油的理化性质十分接近,是非常好的内燃机燃料油的代用品。而且,蒸馏按树油与绿化荒山、培育用材林矛盾不大,建设按树油基地不仅可以解决燃料油的短缺,也可培植用材林,带动地方经济的发展,增加农民收入,是一举多得的事业。     

植物大熊猫——野生红豆杉

野生红豆杉,冰川世纪遗留下来的古老树种,以它顽强的生命力屹立在地球上已几百万年。在人类出现在这个星球以前,它就以红彤彤的红豆果,扮靓了地球的山间和密林。它树姿优美,枝繁叶茂,苍劲挺拔,一派生机盎然,令人敬畏。它果实鲜红,艳丽无比,圆如珍珠,寄托相思之情,令人爱怜。它全身是宝,强身健体,防癌抗癌,历史悠久,令人感动。     

聆听草语

出小小的村落,一直往南走,有一片辽阔的草地。任那向阳的坡坝上,长着墨绿色的草儿们。浓浓的,密密的,人丁旺盛,不像园圃那么单调。蒲公英、野艾、沙拉秧、芨芨草、酢浆草、抽筋草、马齿苋、野羊姜……这些草常常迷幻了我的心与眼。我分不清它们的性别,更不甚清楚它们归属哪个"门派"。眼熟的几个叫着名字,剩下的含混着打个招呼,像人群中那些混个脸熟却不知名姓的人一样。在尘世间活得飞扬跋扈时,我去看草。它们平凡地生活着,宽容,谦让,和平友爱的样子,没有专制,也不自以为     

中华何处无修竹—叫宦溯历史上黄河流域的竹子分布

说起竹子,人们都会想到南方。这不奇怪,野生的竹子主要分布于秦岭和淮河以南,而北方的竹子,基本都是移栽的。可是,如果时光倒流几千年,你也许会发现,在广袤的中华大地上,在中华民族的发源地——黄河流域,到处都有竹子的分布。     

Statistical methods for assessing long-term analyte stability in biological matrices

The objective of a long-term stability experiment is to confirm analyte stability in a given biological matrix, encompassing the duration of time from sample collection to sample analysis for a clinical or preclinical study. While long-term analyte stability has been identified as a key component of bioanalytical method validation, current regulatory guidance provides no specific recommendations regarding the design and analysis of such experiments. This paper reviews and evaluates various experimental designs, data analysis methods, and acceptance criteria for the assessment of long-term analyte stability. Statistical equivalence tests based on linear regression techniques are advocated. Both a nested errors and bivariate mixed model regression approach are suitable for application to long-term stability assessment, and control the risk of falsely concluding stability.     

Genetic Polymorphism for Human Platelet Thermostable Phenol Sulfotransferase (Ts Pst) Activity

Platelet TS PST basal activity and thermal stability were measured in blood samples from 237 individuals in 50 nuclear families. Significant correlations were found among first degree relatives, confirming the previously reported familial aggregation of TS PST basal activity and thermal stability. Commingling analysis of basal TS PST activity provided evidence for multiple component distributions, and after transformation to remove skewness, segregation analysis supported a major gene hypothesis. For TS PST thermal stability, commingling analysis also provided evidence for multiple component distributions. However, segregation analyses were equivocal with regard to the presence of a major gene for thermal stability, since support for a major gene model depended on skewness. Bivariate commingling analysis, which examined thermal stability by simultaneously considering basal activity and activity after heating, suggested that genotypes, as defined by the inferred component distributions for TS PST activity, differ in thermal stability. A three-allele model is proposed as one hypothesis that may account for the combined results of basal activity and thermal stability. The results of this study indicate that a major gene polymorphism in conjunction with polygenic inheritance plays an important role in the regulation of both level of activity and thermal stability of this important drug-metabolizing enzyme in humans.     

Nicholson模型及其同源微分方程的稳定性分析

在描述捕食者—猎物或寄主—寄生物系统的理论模型中,最常见的是Lotka—Volterra方程: 此方程的基本假设之一是认为两个相互作用的物种是完全世代重叠、连续增长的。但是,在自然界,尤其对那些生活周期较短而且受季节气候因子影响较大的昆虫及其天敌,通     

A method of analyzing cultivar x location x year experiments: a new stability parameter

Summary Assessment of cultivar performance in a cultivar x location x year experiment is often difficult because of the presence of a location x year interaction. Our objective is to demonstrate a method on separation of environment effects (location x year) into predictable and unpredictabel components. The analysis consists of two parts: (1) a regression analysis based on location effects (averaged over years), assuming that the location means represent predictable environmental variation; and (2) the estimation of stability (denoted type 4) based on the years within location mean squares, assuming that years within location represent unpredictable environmental variation. From the regression analysis in (1), a breeder can determine the optimum range of locations in which a cultivar is well suited, and from (2) he can choose the most stable cultivars. The advantage of type 4 stability is that it is independent of the other cultivars included in the test and of the regression coefficient estimated for predictable variation. Three sets of published data are used to illustrate the analysis. Type 4 stability is compared with type 3 stability (deviation mean square from regression on environmental index) for genetic consistency. The analyses suggest that type 4 stability is consistent and is therefore a potential genetic parameter, but type 3 stability is not.Contribution No. I-806 from Engineering and Statistical Research Centre, Research Branch, Agriculture Canada, Ottawa, K1A OC6, Canada     

Analysis of the stability of multimeric proteins by effective DeltaG and effective m-values

Analyzing the stability of a multimeric protein is challenging because of the intrinsic difficulty in handling the mathematical model for the folded multimer-unfolded monomer equilibrium. To circumvent this problem, we introduce the concept of effective stability, DeltaGeff (= -RTlnKeff), where Keff is the equilibrium constant expressed in monomer units. Analysis of the denaturant effect on DeltaGeff gives new insight into the stability of multimeric proteins. When a multimeric protein is mostly folded, the dependence of effective stability on denaturant concentration (effective m-value) is simply the m-value of its monomeric unit. However, when the protein is mostly unfolded, its stability depends on denaturant concentration with the m-value of its multimeric form. We also find that the effective m-value at the Cm is a good approximation of the apparent m-value determined by fitting the equilibrium unfolding data from multimeric proteins with a two-state monomer model. Moreover, when the m-value of a monomeric unit is estimated from its size, the effective stability of a multimeric protein can be determined simply from Cm and this estimated m-value. These simple and intuitive approaches will allow a facile analysis of the stability of multimeric proteins. These analyses are also applicable for high-throughput analysis of protein stability on a proteomic scale.     

The thermal stability of the external invertase isoforms from Saccharomyces cerevisiae correlates with the surface charge density

Understanding the effect of surface charge on the stability of proteins is one prerequisite for "tailoring" proteins with increased thermal stability. Here, we investigated the origin of the altered thermal stability observed between the four recently isolated isoforms (EINV1-EINV4) of external invertase. External invertase from yeast Saccharomyces cerevisiae, a homodimeric glycoprotein, represents a widely used model for studying the influence of the glyco component on protein stability. The stability of the four isoforms of invertase decreases from EINV1 to EINV4, which is accompanied by an increase in negative surface charge density. Mass spectrometry analysis revealed that the isoforms share identical protein parts indicating that the differences in stability are the result of post-translational modifications. (31)P NMR analysis revealed that the isoforms contain negatively charged phosphate groups in diester and monoester forms attached to the glycan part. The total amount of phosphate bound to the polymannan component varies between the different isoforms. These results, together with the analysis of the amount of polymannan components, show that negative surface charge density does not entirely depend on the amount of phosphate but rather on its distribution. This suggests that charged groups bound to the glyco-component of a protein can influence the stability of glycoproteins.     

Stability in legged locomotion

Stability is a key element in a gait synthesis. Static stability margins are widely adopted in crawlers, while no similar approach has been developed for dynamically stable systems. Utilizing an analytical approach, we developed a set of easy-to-calculate stability indices to describe instantaneous static and dynamic (In)stability for a certain group of walking systems. The analysis is based on a thorough analysis of the interaction between ground reaction forces and the walking system. The indices are applicable to walking systems regardless of the number of legs or mechanical/biological design. We show that static and dynamic stability are independent of each other. We suggest a possible categorization of gait modes based on stability. Stability characteristics are analyzed in a healthy and highly pathological human gait. Finally, we discuss the applicability of the proposed methods.     

用GGE双标图分析甘蔗品种性状稳定性及试点代表性

算术平均法经常被用于评估甘蔗品种产量的稳定性和适应性,并用方差分析来估计区域试验的试验误差.然而,地点和年份的差异使品种的差异难以得到准确评估.为客观评价甘蔗品种的稳定性和适应性,本研究采用GGE双标图对2008-2009年我国甘蔗区域试验5个试点中的7个甘蔗品种试验数据进行分析.结果表明:福农30号为蔗茎产量高且稳产性高的品种,粤甘18号为含糖量高且性状稳定的品种,福农28号和云蔗99-91为高蔗糖分且性状稳定的品种,粤甘16号的蔗茎产量和含糖量最高,但稳定性一般;在各试点中,福建漳州和广东遂溪的代表性和鉴别力较强.GGE双标图分析为客观评价甘蔗参试品种的丰产性和稳定性提供了直观、有效的手段,为甘蔗新品种的鉴定与推广提供了科学依据.     

微生物生长稳定性超熵产生判据

运用非平衡热力学超熵产生理论和微生物生长动力学理论,以细胞、营养物和产物为参量,求得了微生物生长的超熵产生及稳定性判据,理论分析与实验计算结果基本一致．