共查询到20条相似文献,搜索用时 453 毫秒
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Thomas Dugé de Bernonville Emilien Foureau Claire Parage Arnaud Lanoue Marc Clastre Monica Arias Londono Audrey Oudin Benjamin Houillé Nicolas Papon Sébastien Besseau Ga?lle Glévarec Lucia Atehortùa Nathalie Giglioli-Guivarc’h Benoit St-Pierre Vincenzo De Luca Sarah E. O’Connor Vincent Courdavault 《BMC genomics》2015,16(1)
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Hui-Yeng Y Yap Yit-Heng Chooi Mohd Firdaus-Raih Shin-Yee Fung Szu-Ting Ng Chon-Seng Tan Nget-Hong Tan 《BMC genomics》2014,15(1)
Background
The sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden or Tiger milk mushroom (Polyporales, Basidiomycota) is a valuable folk medicine for indigenous peoples in Southeast Asia. Despite the increasing interest in this ethnobotanical mushroom, very little is known about the molecular and genetic basis of its medicinal and nutraceutical properties.Results
The de novo assembled 34.3 Mb L. rhinocerotis genome encodes 10,742 putative genes with 84.30% of them having detectable sequence similarities to others available in public databases. Phylogenetic analysis revealed a close evolutionary relationship of L. rhinocerotis to Ganoderma lucidum, Dichomitus squalens, and Trametes versicolor in the core polyporoid clade. The L. rhinocerotis genome encodes a repertoire of enzymes engaged in carbohydrate and glycoconjugate metabolism, along with cytochrome P450s, putative bioactive proteins (lectins and fungal immunomodulatory proteins) and laccases. Other genes annotated include those encoding key enzymes for secondary metabolite biosynthesis, including those from polyketide, nonribosomal peptide, and triterpenoid pathways. Among them, the L. rhinocerotis genome is particularly enriched with sesquiterpenoid biosynthesis genes.Conclusions
The genome content of L. rhinocerotis provides insights into the genetic basis of its reported medicinal properties as well as serving as a platform to further characterize putative bioactive proteins and secondary metabolite pathway enzymes and as a reference for comparative genomics of polyporoid fungi.Electronic supplementary material
The online version of this article (doi:10.1186/1471-2164-15-635) contains supplementary material, which is available to authorized users. 相似文献16.
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