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The KDM4 subfamily of JmjC domain-containing demethylases mediates demethylation of histone H3K36me3/me2 and H3K9me3/me2. Several studies have shown that human and yeast KDM4 proteins bind to specific gene promoters and regulate gene expression. However, the genome-wide distribution of KDM4 proteins and the mechanism of genomic-targeting remain elusive. We have previously identified Drosophila KDM4A (dKDM4A) as a histone H3K36me3 demethylase that directly interacts with HP1a. Here, we performed H3K36me3 ChIP-chip analysis in wild type and dkdm4a mutant embryos to identify genes regulated by dKDM4A demethylase activity in vivo. A subset of heterochromatic genes that show increased H3K36me3 levels in dkdm4a mutant embryos overlap with HP1a target genes. More importantly, binding to HP1a is required for dKDM4A-mediated H3K36me3 demethylation at a subset of heterochromatic genes. Collectively, these results show that HP1a functions to target the H3K36 demethylase dKDM4A to heterochromatic genes in Drosophila. 相似文献
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Jarid1b targets genes regulating development and is involved in neural differentiation 总被引:1,自引:0,他引:1
Schmitz SU Albert M Malatesta M Morey L Johansen JV Bak M Tommerup N Abarrategui I Helin K 《The EMBO journal》2011,30(22):4586-4600
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Guang Shi Meng Wu Lan Fang Fang Yu Shimeng Cheng Jiwen Li James X. Du Jiemin Wong 《The Journal of biological chemistry》2014,289(43):29691-29700
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