共查询到20条相似文献,搜索用时 953 毫秒
1.
Hang Yin Alessandra Pasut Vahab D. Soleimani C. Florian Bentzinger Ghadi Antoun Stephanie Thorn Patrick Seale Pasan Fernando Wilfred van IJcken Frank Grosveld Robert A. Dekemp Robert Boushel Mary-Ellen Harper Michael A. Rudnicki 《Cell metabolism》2013,17(2):210-224
Highlights? Satellite cells can differentiate into brown adipocytes ? MicroRNA-133 targets Prdm16 3′UTR and controls brown adipose determination ? MicroRNA-133 antagonism induces active brown adipocytes within regenerating muscle ? MicroRNA-133 antagonism impedes the development of obesity 相似文献
2.
Sona Rajakumari Jun Wu Jeff Ishibashi Hee-Woong Lim An-Hoa Giang Kyoung-Jae Won Randall R. Reed Patrick Seale 《Cell metabolism》2013,17(4):562-574
Highlights? Ebf2 is selectively expressed in brown relative to white adipocytes and binds to chromatin at brown fat-specific target sites of Pparγ ? Ebf2 expression in white fat or muscle precursor cells recruits Pparγ to its brown fat-specific gene targets and drives a complete program of brown adipocyte differentiation ? Brown adipose cells and tissue from Ebf2-deficient mice display a complete loss of thermogenic characteristics while gaining molecular attributes of white adipose 相似文献
3.
Highlights? PPARγ full agonists induce a brown fat phenotype in subcutaneous WAT ? PRDM16 is required for the development of PPARγ agonist-inducible brow adipocytes ? PRDM16 and PPARγ agonists synergistically activate the brown fat gene program ? Browning effect is mediated through the enhanced stability of the PRDM16 protein 相似文献
4.
Tuo Deng Christopher J. Lyon Laurie J. Minze Jianxin Lin Jia Zou Joey Z. Liu Yuelan Ren Zheng Yin Dale J. Hamilton Patrick R. Reardon Vadim Sherman Helen Y. Wang Kevin J. Phillips Paul Webb Stephen T.C. Wong Rong-fu Wang Willa A. Hsueh 《Cell metabolism》2013,17(3):411-422
Highlights? Obesity enhances MHCII expression in primary human and mouse adipocytes ? Adipocytes activate CD4+ ARTs via MHCII and leptin to induce adipose inflammation ? Macrophage changes in adipose follow adipocyte and T cell interactions during HFD ? Adaptive immune mechanisms are essential to obesity-induced adipose inflammation 相似文献
5.
Nikki Charles Tatsuya Ozawa Massimo Squatrito Anne-Marie Bleau Cameron W. Brennan Dolores Hambardzumyan Eric C. Holland 《Cell Stem Cell》2010,6(2):141-152
Highlights? Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ? Notch signaling drives tumor stem-like characteristics and reduces survival ? Loss of eNOS activity decreases tumor stem-like characteristics ? Suppressing eNOS activity prolongs survival in glioma-bearing mice 相似文献
6.
Wang H Astarita G Taussig MD Bharadwaj KG DiPatrizio NV Nave KA Piomelli D Goldberg IJ Eckel RH 《Cell metabolism》2011,13(1):105-113
Highlights? Mice with lipoprotein lipase deficiency in neurons (NEXLPL) are obese ? NEXLPL mice develop obesity by modifying both food intake and energy expenditure ? NEXLPL mice have increases in hypothalamic AgRP/NPY gene expression before obesity ? NEXLPL mice demonstrate deficiencies in n-3 fatty acids in the hypothalamus 相似文献
7.
Emilio Arteaga-Solis Tiffany Zee Charles W. Emala Charles Vinson Jürgen Wess Gerard Karsenty 《Cell metabolism》2013,17(1):35-48
Highlights? Leptin regulates airway diameter, independently of body weight and inflammation ? Leptin uses the parasympathetic tone to regulate airway diameter ? Modulating the parasympathetic tone can correct bronchoconstriction in obese mice 相似文献
8.
Virginie Mansuy-Aubert Qiong L. Zhou Xiangyang Xie Zhenwei Gong Jun-Yuan Huang Abdul R. Khan Gregory Aubert Karla Candelaria Shantele Thomas Dong-Ju Shin Sarah Booth Shahid M. Baig Ahmed Bilal Daehee Hwang Hui Zhang Robin Lovell-Badge Steven R. Smith Fazli R. Awan Zhen Y. Jiang 《Cell metabolism》2013,17(4):534-548
Highlights? Obese men and mice have decreased serum A1AT levels and increased NE activity ? Neutrophil infiltration and NE deposition occur in adipose tissue from HFD-fed mice ? NE?/? and A1AT Tg mice have reduced HFD-induced insulin resistance and inflammation ? NE deletion increases AMPK signaling and fatty acid oxidation in liver and BAT 相似文献
9.
Wen-Mei Yu Xia Liu Jinhua Shen Olga Jovanovic Elena E. Pohl Stanton L. Gerson Toren Finkel Hal E. Broxmeyer Cheng-Kui Qu 《Cell Stem Cell》2013,12(1):62-74
Highlights? PTPMT1 depletion causes cell cycle delay and differentiation block in HSCs ? The HSC pool in PTPMT1 knockout mice is drastically (~40-fold) expanded ? Mitochondrial metabolism is altered and AMPK is highly activated in knockout HSCs ? PTPMT1 PIP substrates directly enhance fatty-acid-induced activation of UCP2 相似文献
10.
Highlights? AS160 Thr649→Ala knockin mice are made to study roles of AS160/14-3-3 interaction ? The knockin mice display impaired glucose tolerance and reduced insulin sensitivity ? Deregulated GLUT4 trafficking and glucose uptake in muscles underlie this phenotype ? These findings shed new light on understanding of the pathology of type II diabetes 相似文献
11.
Barak H Huh SH Chen S Jeanpierre C Martinovic J Parisot M Bole-Feysot C Nitschké P Salomon R Antignac C Ornitz DM Kopan R 《Developmental cell》2012,22(6):1191-1207
Highlights? FGF20 and FGF9 are the niche ligands for developing metanephric kidney progenitors ? FGF9 is expressed in duct epithelia; both ligands are expressed by progenitor cells ? FGF20 loss in humans, or FGF9/20 loss in mice, results in kidney agenesis ? FGF9/20 can maintain competence of sorted, pure progenitor cell populations in vitro 相似文献
12.
Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression 相似文献
13.
Highlights? AtBMI1A/B proteins prevent misexpression of embryonic traits in somatic cells ? PRC2 and AtBMI1A/B proteins maintain cells in their differentiated state ? AtBMI1A/B proteins mediate H2A monoubiquitination 相似文献
14.
Hume Stroud Maxim V.C. Greenberg Suhua Feng Yana V. Bernatavichute Steven E. Jacobsen 《Cell》2013,152(1-2):352-364
Highlights? Genome-wide single-nucleotide resolution methylation maps in 86 silencing mutants ? Complex interplays between different DNA methylation pathways ? Identification of novel regulators of DNA methylation 相似文献
15.
Sheila A. Anderson Christopher P. Nizzi Yuan-I. Chang Kathryn M. Deck Paul J. Schmidt Bruno Galy Alisa Damnernsawad Aimee T. Broman Christina Kendziorski Matthias W. Hentze Mark D. Fleming Jing Zhang Richard S. Eisenstein 《Cell metabolism》2013,17(2):282-290
Highlights? Derepression of HIF-2α mRNA in Irp1?/? mice causes age-dependent polycythemia ? HIF-2α hyperactivity is observed in multiple tissues of Irp1?/? mice ? The mRNA regulons of IRP1 and IRP2 are separable in vivo ? The IRP1-HIF-2α axis is a therapeutic target for hematologic or oncologic disorders 相似文献
16.
17.
Daniel J. Bumbarger Metta Riebesell Christian Rödelsperger Ralf J. Sommer 《Cell》2013,152(1-2):109-119
Highlights? Massive neural circuit rewiring between nematodes with divergent feeding behavior ? Striking patterns correlate with known functional differences ? Motor synapse differences indicate a substantial change in information flow ? Correlates of predatory feeding behavior are identified 相似文献
18.
John-Stuart Brittain Penny Probert-Smith Tipu Z. Aziz Peter Brown 《Current biology : CB》2013,23(5):436-440
Highlights? Phase-cancelling cortical stimulation attenuates Parkinsonian tremor ? Prolonged stimulation may invoke adaptive mechanisms ? Phase cancellation may provide a generic treatment approach to oscillopathies ? TACS provides a convenient probe of cortical circuit dynamics in humans 相似文献
19.
Adkar BV Tripathi A Sahoo A Bajaj K Goswami D Chakrabarti P Swarnkar MK Gokhale RS Varadarajan R 《Structure (London, England : 1993)》2012,20(2):371-381
Highlights? Individual mutant phenotypes in a saturation library derived via deep sequencing ? Residue depth and active-site residue derivation from mutant phenotypes ? Mutant-phenotype-derived parameters used for protein model discrimination ? Derivation of sequence-structure-function relationships without protein isolation 相似文献
20.
MTR1 encodes a secretory fasciclin glycoprotein required for male reproductive development in rice 总被引:1,自引:0,他引:1
Highlights? The fasciclin glycoprotein MTR1 regulates male reproductive development in rice ? Rice male reproductive cells secrete MTR1 to control somatic tapetum development 相似文献