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Sarcopenia is a common and prominent geriatric syndrome, of major interest for daily clinical practice of professionals working with older people. The number of affected individuals and its relation with disability, frailty, many chronic diseases, lifestyle and adverse outcomes are extremely relevant for geriatric care. Moreover, biological changes that lead to the loss of muscle mass and strength are intrinsically related to the mechanisms of aging. It is not therefore surprising that research in this field is growing exponentially in recent years, and sarcopenia has been placed in recent years in the forefront of research in geriatric medicine and gerontology. The Spanish Society of Geriatrics and Gerontology has recently created an Observatory of Sarcopenia, which aims to promote educational and research activities in this field. The first activity of the Observatory has been to offer the Spanish speaking scientific community a review of the current status of sarcopenia, that may allow unifying concepts and fostering interest in this promising field of geriatrics.  相似文献   

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The coronavirus disease 2019 (COVID-19) produces severe respiratory symptoms such as bilateral pneumonia associated to a high morbidity and mortality, especially in patients of advanced age. Vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and dysregulation of the immune system. Vitamin D in modulates immune function too. Vitamin D receptor (VDR) is expressed by most immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells and the signalling of vitamin D and VDR together has an anti-inflammatory effect. Some studies have reported that vitamin D treatment could be useful for the prevention and treatment of COVID-19 because vitamin D plays an important role as a modulator of immunocompetence. Over the last few months, some studies have hypothesized the possible beneficial effect of vitamin D supplementation in patients with COVID-19 in order to improve the immune balance and prevent the hyperinflammatory cytokine storm. Some preliminary studies have already shown promising results with vitamin D supplementation in hospitalized COVID-19 patients. Vitamin D should be administered daily until adequate levels are achieved due to vitamin D behaves as a negative acute phase reactant (APR). Despite the lack of evidence on specific doses of vitamin D to treat COVID-19 in older adults, authors consider it is necessary to standardize the use in clinical practice. These recommendations advice supplement vitamin D in a protocoled fashion based on expert opinions, level of evidence 5.  相似文献   

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Last decade, the Government of Catalonia have urged an integrated care strategy for planning the care model to older populations living with frailty, multimorbidity and advanced illnesses. Based on international evidence that was reviewed by a group of experts from the Catalan Society of Gerontology and Geriatrics, we summarised some recommendation to adapt hospital-at-home care to older populations in our system. We defined Comprehensive Geriatric Assessment (CGA) hospital-at-home (HaH) as a specialised home hospitalisation service formed by interdisciplinary teams, characterised by using the clinical methodology of CGA, and by adapting geriatric units’ protocols for the provision of person-centred care at home. Main benefits of CGA-HaH in these populations are: response to heath crises according to individualised care plans based on the situational diagnosis carried out by Primary Care teams; provision of a comprehensive health and social approach tailored to the complexity of cases and situations; and adaptation of multipurpose hospitalisation, by working on different person-centred care, aspects, such as caregivers support on care provision, focusing on function or home adaptation.  相似文献   

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Geriatrics     
Ronald D.T. Cape 《CMAJ》1984,130(4):510-511
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The elderly population is rapidly increasing, reflecting the fact that better pre- and post-natal care, better nutrition, immunizations, antibiotics, and better general hygiene have reduced infant, childhood and young adulthood mortality. There are now more of us around to live longer. It is therefore important to develop gerontologic research programs aimed at understanding the normal aging process. We need to know what age-related changes are irreversible concomitants of the passage of time and what age-related changes are associated with various diseases, life-styles and cultures. It is possible that life-style, diet and genetic characteristics, which retard or accelerate aging, can be identified and thus have major public health implications. Aging brings about an unusual immunologic situation that has not yet been thoroughly explained. The primary effect of normal aging on the immune system appears to be a decrease in thymus derived or T-cell functional capacity, especially in the suppressor subpopulation of T-cells. There is also an age associated hyperglobulinemia with an increase in normal autoantibody titer. Thus, one can propose that the T supressor inhibition of B lymphocytes is released in older individuals, allowing B cells an increase in functional response, especially to “slightly altered” self. The implications of these changes to the processes of chronic destructive periodontitis and oral cancer must be explained and eventually understood if we are to prevent and/or successfully treat them.  相似文献   

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Mamaev  V. B. 《Biophysics》2018,63(5):831-835
Biophysics - Abstract—Currently, gerontology is changing its priorities. If yesterday the main was search for biological mechanisms of aging (independent work of gerontologists), that today...  相似文献   

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The first year''s work at a new geriatric department at Northwick Park Hospital shows that active policies revolutionize the geriatric service and result in high turnover of patients and no waiting list. Comparison with low turnover/waiting list departments shows the effects of a waiting list in terms of diminished therapeutic benefit and less favourable outcome for patients admitted. The requirements for elimination of the waiting list appear to be well directed policies and adequate and enthusiastic staff. Active geriatrics results in high morale and could be widely applicable within the present hospital bed resources given the necessary improvements in staffing.  相似文献   

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