共查询到20条相似文献,搜索用时 35 毫秒
1.
2.
3.
K J Petty B Desvergne T Mitsuhashi V M Nikodem 《The Journal of biological chemistry》1990,265(13):7395-7400
4.
5.
6.
7.
8.
Thyroid hormone regulates the mouse thyrotropin beta-subunit gene promoter in transfected primary thyrotropes 总被引:13,自引:0,他引:13
W M Wood M Y Kao D F Gordon E C Ridgway 《The Journal of biological chemistry》1989,264(25):14840-14847
9.
10.
Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon 总被引:12,自引:0,他引:12
F E Wondisford E A Farr S Radovick H J Steinfelder J M Moates J H McClaskey B D Weintraub 《The Journal of biological chemistry》1989,264(25):14601-14604
11.
12.
M F Norman T N Lavin J D Baxter B L West 《The Journal of biological chemistry》1989,264(20):12063-12073
13.
14.
15.
16.
D J Drucker J Philippe L Jepeal J F Habener 《The Journal of biological chemistry》1987,262(32):15659-15665
17.
18.
Identification of a cyclic adenosine monophosphate-responsive element in the rat corticotropin-releasing hormone gene 总被引:6,自引:0,他引:6
A F Seasholtz R C Thompson J O Douglass 《Molecular endocrinology (Baltimore, Md.)》1988,2(12):1311-1319
The molecular mechanisms involved in the regulation of expression of the rat CRH gene have been examined in rat pheochromocytoma (PC-12) cells transiently transfected with a chimeric gene containing 1.4 kilobases of rat CRH 5'-flanking DNA fused to the bacterial reporter gene encoding chloramphenicol acetyltransferase. Cyclic AMP analogs and activators of adenylate cyclase positively regulate the expression of this chimeric gene in PC-12 cells, inducing chloramphenicol acetyltransferase activity more than 15-fold. The DNA sequence required for this response to cAMP has been localized to a 59 base pair region located between 238 and 180 base pairs 5' to the putative CRH mRNA cap site. This sequence can confer cAMP-responsiveness on a heterologous promoter in an orientation independent fashion and has homology to cAMP regulatory regions from a number of other eukaryotic genes. 相似文献
19.
20.