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Vlasta Korunová Zdenka Škodová Jiří Dědina Zdeněk Valenta Jiří Pařizek Zbyněk Píša Miroslav Stýblo 《Biological trace element research》1993,37(2-3):91-99
The serum selenium levels in 367 healthy adult (25–64 yr) Central Bohemia residents, 176 men and 191 women, were determined
using atomic absorption spectrometry. An extremely wide range of values was found in the whole population sample (<20–296
μg/L) as well as in each sex or age category studied. The mean selenium concentration and 95% confidence interval calculated
after logarithmic transformation of the data were 74 μg/L (71–77) for the whole population sample, 72 μg/L (67–76) for men,
and 76 μg/L (72–81) for women. About 10% of the residents exhibited serum selenium level below 45 μg/L. There was no significant
correlation between serum selenium and sex, age, or smoking status of participants. However, the lowest average level was
found in the group of heavy smoking women: 66 μg/L. The selenium status of the Central Bohemia population seems to be below
European average. Groups of residents having a very low nutritional selenium intake may be expected to occur in this population.
Dedicated to the memory of Jiří Pařízek, former head of environmental physiology research group of the Institute of Nuclear
Biology and Radiochemistry. 相似文献
3.
Bogumiła Pilarczyk Diana Hendzel Renata Pilarczyk Agnieszka Tomza-Marciniak Barbara Błaszczyk Marta Dąbrowska-Wieczorek Małgorzata Bąkowska Ewa Adamowicz Tomasz Bujak 《European Journal of Wildlife Research》2010,56(5):797-802
The aim of this study was to determine liver and kidney concentrations of selenium in wild boars from the northwest part of
Poland, depending on season of the year, age, sex, and body weight. Altogether, samples of livers and kidneys from 172 wild
boars that were shot in 2005–2008 were investigated. Liver and kidney concentrations of selenium were determined using spectrofluorometric
method. In all the animals studied, selenium concentration was several times lower in the liver than in the kidneys. Selenium
concentration averaged 0.19 μg/g wet weight (w.w.) in the liver and 1.20 μg/g w.w. in kidneys. The present study showed that
season (P ≤ 0.05), age (P ≤ 0.01), and body weight (P ≤ 0.01) have a significant effect on selenium concentration in the liver of wild boars. Liver selenium concentration was
the highest in spring (0.23 μg/g w.w.) and the lowest in autumn (0.16 μg/g w.w). Young animals (up to 1 year of age) and those
with the lowest body weight (up to 20 kg) were characterized by a slightly lower selenium concentration in the liver compared
to older and heavier animals. No significant differences were found in organ selenium concentration between males and females.
According to biochemical criteria for the diagnosis of selenium deficiency in pig liver, which were used to evaluate selenium
concentration in the liver of wild boars, no individuals were found to have optimal levels. Considering that in Se deficiency
higher selenium concentrations are found in kidneys than in the liver, it can be presumed that the wild boars had Se deficiency.
However, this is difficult to state conclusively because there are no reference values for this species. 相似文献
4.
Characteristics of Se-Enriched Mycelia by Stropharia rugoso-annulata and its Antioxidant Activities in vivo 总被引:1,自引:0,他引:1
Zhen Song Le Jia Feng Xu Fanyun Meng Peng Deng Keming Fan Xiaonan Liu 《Biological trace element research》2009,131(1):81-89
Selenium (Se) is an essential trace element for humans and animals. Stropharia rugoso-annulata is a nutritional and functional mushroom containing many kinds of bioactive ingredients. The aims of this study were to investigate
the Se-enrichment characteristics of S. rugoso-annulata in submerged culture and evaluate the antioxidant activities of Se-enriched mycelia in vivo in terms of the values of glutathione
peroxidase (GSH-Px), superoxide dismutase (SOD), and malondialdehyde (MDA). The optimum parameters of Se-enrichment under
the optimal Se concentration (150 μg/mL) in media were as follows: biomass 8.11 ± 0.25 g/L, Se content in mycelia 4,727.68 ± 13 μg/g,
Se-accumulated rate 24.68 ± 1.67%, and percentage of organic Se 96.27 ± 3.26%. The mainly subsistent forms of selenium in
Se-enriched mycelia were selenoprotein and selenium-polysaccharide. The contents of total amino acids (TAA) and essential
amino acids (EAA) in Se-enriched mycelia were increased by 13.5 ± 1.09% and 12.8 ± 0.89%, respectively. It was efficient for
Se-enriched mycelia to elevate GSH-Px and SOD activities and decrease MDA content. These results indicated that Se-enriched
mycelia of S. rugoso-annulata represent a novel dietary source of bioavailable supplemental selenium. 相似文献
5.
Young-Jae Kim Oyunbileg Galindev Jun Han Sei Su-Mi Bae Hosub Im Lanying Wen Young Rok Seo Woong Shick Ahn 《Biological trace element research》2009,131(2):103-109
Of trace elements in the serum of living organisms, selenium (Se) is an essential mineral and plays the role of an antioxidant
as selenoproteins protecting the organism against oxidative damage induced by hydrogen peroxide, other lipid hydroperoxides,
and their derivatives. The aim of this study was to determine the mean serum Se levels in healthy Korean volunteers (50 males
and 50 females) by using an inductively coupled plasma-mass spectrometry method. The samples were collected at the Health
Promotion Centre of Kangnam St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, Kangnam District,
Seoul in accordance with procedures approved by the Institutional Review Board of the Catholic University of Korea. The mean
serum Se level in healthy subjects was 112.05 ± 30.42 μg/l. For gender, it was 120.81 ± 27.37 μg/l for females and 103.29 ± 31.05 μg/l
for males. From the study result, there was a significant difference between the mean Se concentrations of gender groups (p = 0.0035). Also, the study indicated no effect of age on Se levels (p > 0.05) in the healthy individuals. 相似文献
6.
Jetmund Ringstad Synnøve F. Knutsen Odd R. Nilssen Yngvar Thomassen 《Biological trace element research》1993,36(1):65-71
Depressed selenium and Vitamin E levels may contribute to hepatic injury through lipid peroxidation. To study the effect of
moderate alcohol drinking (32.4±23.6 g ethanol/d) on serum selenium and serum vitamin E concentrations, we conducted a matched-pair
study of 73 healthy, well-nourished risk drinkers and healthy controls with little or no alcohol consumption. Among risk drinkers,
serum selenium was significantly lowered (1.49 vs 1.67 μmol/L;p<0.001) compared with controls. Difference in α-tocopherol concentrations did not, however, reach statistical significance
(22.8 vs 24.9 μmol/L;p=0.06). Nutritional and life-style factors differed very little between the two groups. We conclude that even moderate alcohol
consumption lowers selenium status. Selenium may thus represent a link joining the hepatotoxic and nutritional backgrounds
of alcoholic liver disease. 相似文献
7.
Tascilar ME Ozgen IT Abaci A Serdar M Aykut O 《Biological trace element research》2011,143(1):188-195
The quality of the diet of obese children is poor. Eating habits may alter micronutrient status in obese patients. In this
study, we determined the serum levels of selenium, zinc, vanadium, molybdenum, iron, copper, beryllium, boron, chromium, manganese,
cobalt, silver, barium, aluminum, nickel, cadmium, mercury, and lead in obese Turkish children. Thirty-four obese and 33 healthy
control subjects were enrolled in the study. Serum vanadium and cobalt levels of obese children were significantly lower than
those of the control group (0.244 ± 0.0179 vs. 0.261 ± 0.012 μg/l, p < 0.001, and 0.14 ± 0.13 vs. 0.24 ± 0.15 μg/l, p = 0.011, respectively). There was no significant difference between groups regarding the other serum trace element levels.
In conclusion, there may be alterations in the serum levels of trace elements in obese children and these alterations may
have a role in the pathogenesis of obesity. 相似文献
8.
Abakay A Gokalp O Abakay O Evliyaoglu O Sezgi C Palanci Y Ekici F Karakus A Tanrikulu AC Ayhan M 《Biological trace element research》2012,145(2):151-157
The aim of this study was to investigate the respiratory function disorders that could be related to dust exposure during
the production of copper mine in copper mineworkers (CMWs). The study included 75 male CMWs (mean age, 32.0 ± 7.1 years, 58.6%
smokers) and 75 male age- and smoking status-matched healthy control subjects. Serum Cu level was significantly higher in
the CMW group (0.80 ± 0.62 μg/ml) than the control group (0.60 ± 0.39 μg/ml) (p = 0.017). Significant negative correlations were found between serum Cu level and forced expiratory volume in first second
(r = −0.600; p < 0.001) and between serum Cu level and forced vital capacity (r = −0.593; p = <0.001) in CMWs. Serum Cu level was significantly higher in the restrictive type pulmonary function disorders group (1.36 ± 0.62 μg/ml)
than obstructive type (0.90 ± 0.55 μg/ml) and normal pulmonary function pattern group (0.53 ± 0.43 μg/ml) (p < 0.001). Patients with radiological parenchymal abnormalities had significantly higher serum copper levels than those without
abnormalities (1.53 ± 0.52 vs. 0.71 ± 0.52 μg/ml, respectively; p = 0.002). In conclusion, result of the study has shown a negative association between pulmonary functions disorders and radiological
abnormalities and serum Cu levels in CMWs. 相似文献
9.
Bogumiła Pilarczyk Aleksandra Balicka-Ramisz Alojzy Ramisz Ewa Adamowicz Renata Pilarczyk Agnieszka Tomza-Marciniak Małgorzata Bąkowska 《European Journal of Wildlife Research》2009,55(3):279-283
The aim of this study was to determine concentrations of selenium in the liver and kidneys of roe deer and red deer from West
Pomerania, depending on the season. Altogether, samples from 169 animals were collected (96 from roe deer and 73 from red
deer) in 2003–2007. The mean concentration of selenium in the liver of red deer and roe deer was 0.37 μg/g and 0.62 μg/g dry
weight, respectively. In kidneys, Se concentration was 2.72 μg/g d.w. in red deer and 2.99 μg/g d.w. in roe deer. In roe deer,
liver selenium concentration in autumn was significantly higher than in winter (P < 0.05) and spring (P < 0.01) and significantly lower in spring than in summer (P < 0.05); likewise, kidney selenium concentration was higher in autumn than in summer. In deer, no statistically significant
season-related differences were observed for liver selenium concentrations. In red deer kidneys, selenium concentration was
the lowest in summer, significantly lower than in autumn and winter. Low selenium concentrations in the analyzed tissues show
that the animals live in areas deficient in this element. 相似文献
10.
Fatemi Naieni F Ebrahimi B Vakilian HR Shahmoradi Z 《Biological trace element research》2012,146(1):30-34
Premature graying of hair with unclear etiology, which is known as premature canities, is a common cause of referrals to the
dermatologists. We assessed the relationship between serum iron, copper, and zinc concentrations with premature canities.
This study was conducted on patients under 20 years old suffering from premature canities, having a minimum of ten gray hair
fibers, and referring to university hospitals of Isfahan (Iran). The results were compared with age–sex-matched controls.
Demographic data and disease characteristics were recorded for two groups. We studied serum iron, copper, and zinc concentrations
of 66 patients and 66 controls using atomic absorption and Ferrozine methods. The mean age of studied cases was 17.8 ± 2.0 years,
and the mean age of the onset of canities was 15.5 ± 3.2 years with no significant difference between males and females (P > 0.05). Serum copper concentration was significantly lower in patients compared with controls (90.7 ± 37.4 vs. 105.3 ± 50.2 μg/dL,
P = 0.048), but serum iron concentration was significantly lower in controls compared to patients (88.8 ± 39.5 vs. 108.3 ± 48.4 μg/dL,
P = 0.008). Also, there was no significant difference between patients and controls in serum zinc concentration (114.8 ± 67.8
vs. 108.2 ± 49.9 μg/dL, P = 0.285). According to these results, among copper, zinc, and iron, a low serum copper concentration may play a role in premature
graying of hairs in our society. Further studies are needed to find the underlying mechanism of this relationship. 相似文献
11.
Ozkaya M Sahin M Cakal E Gisi K Bilge F Kilinc M 《Biological trace element research》2009,128(2):144-151
The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR)
according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied
in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 ± 5.9 vs 88.7 ± 8.7 μg/dl,
p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 ± 0.9
vs 0.63 ± 0.4 mg/dL, p < 0.0001; 2.07 ± 0.84 vs 1.51 ± 0.69, p < 0.0001; 9.26 ± 3.8 vs 6.8 ± 2.98 μU/MI, p < 0.0001; 15.7 ± 7.4 vs 11.5 ± 5.1 μmol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = − 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = −0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine
levels in individuals with selenium levels < 80 μg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels ≥ 80 (n = 91; 1.23 ± 0.98 vs 0.81 ± 0.76 mg/dL, p < 0.003; 1.99 ± 0.88 vs 1.64 ± 0.74, p < 0.005; 15.0 ± 7.6 vs 12.9 ± 5.7 μmol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR. 相似文献
12.
Selenium-enriched tea was suggested as a possible source of supplemental Se. The result of this study indicates that it is
not practicable to make selenium-enriched tea as a beverage like traditional green tea or black tea for the supplementation
of selenium in human diet. The selenium dispersibilities of fresh tea leaves, green tea, and black tea highly correlated with
those of protein (r
2 = 0.998). The high protein dispersibility (85.0%) of fresh tea leaves in water solution was accompanied by that of selenium
(93.8%). Decreases in protein dispersibility of green tea and black tea to 2.5% and 4.2 % coincided with those of selenium
to only 8.3% and 10.1%, respectively. The amount (14.90 μg) of selenium in saturated ammonium sulphate (a protein precipitating
reagent) precipitate was 83.8% of that (17.79 μg) in fresh tea leaf extract, and after the saturated ammonium sulphate precipitate
was dialyzed against distilled water overnight, the amount (14.37 μg) of selenium remaining in the dialyzed precipitate (protein)
was still 80.8% of that in the fresh tea leaf extract. However, there were no significant differences (p > 0.05) between the amount of selenium in the saturated ammonium sulphate precipitate and that in the saturated ammonium
sulphate precipitate that was dialyzed. 相似文献
13.
Deficiencies in Cu, Se, and Zn impair one or more biochemical functions, and excess are associated with toxicity. Baseline
studies on the Ghanaian population are scanty. The study was undertaken to determine whether significant rural/urban differences
in the serum levels of Cu, Se, and Zn did exist. Forty males/60 females from rural and 50 males/50 females from urban Ghanaian
communities were sampled. Serum Cu, Se, and Zn were determined using flame atomic absorption spectrometry. Cu level for rural
and urban subjects was 997 ± 333 and 979 ± 290 μg/L, respectively (p = 0.68). However, Cu levels were significantly higher in the rural females (1,063 ± 367 μg/L) than the rural males (898 ± 249 μg/L;
p = 0.0085). Se levels for rural/urban subjects were 97 ± 36 and 87 ± 31 μg/L, respectively (p = 0.03). Zn levels in the rural/urban subjects were 312 ± 218 and 150 ± 102 μg/L, respectively (p = 0.002). Additionally, Zn was significantly higher in rural females (428 ± 204 μg/L) than the urban females (166 ± 103 μg/L;
p = 0.0002). Finally, Zn was significantly higher in rural females (428 ± 204 μg/L) than males (172 ± 116 μg/L; p = 0.0028). In conclusion, Cu, Se, and Zn were higher in the rural group compared to the urban group, and the generally low
Zn levels were confirmed in another cohort follow-up study. 相似文献
14.
Ersoy IH Koroglu BK Varol S Ersoy S Varol E Aylak F Tamer MN 《Biological trace element research》2011,143(2):619-624
Although there are many studies on effect of fluoride on trace elements in experimental animals, few studies exist on serum
trace elements levels in patients with endemic fluorosis. We aimed to determine the serum levels of trace elements including
serum copper (Cu), zinc (Zn), and serum levels of minerals including calcium (Ca), phosphorus (P), magnesium (Mg), sodium
(Na), potassium (K) in patients with endemic fluorosis. The study group consisted of 30 patients with endemic fluorosis (17
females, 13 males, mean age 33.53 ± 9.85 years). An age, gender, and body mass index matched 30 healthy volunteers comprised
control group (21 females, ten males with a mean age 33.93 ± 7.39 years). Urine fluoride levels of chronic fluorosis patients
were significantly higher than that of control subjects as expected (1.92 ± 0.10 mg/l vs. 0.41 ± 0.09 mg/l, respectively;
P < 0.001). Serum Cu levels (89.14 ± 16.77 μg/dL vs. 102.69 ± 25.04 μg/dL, respectively, P = 0.017), serum Zn levels (77.98 ± 20.58 μg/dL vs. 94.57 ± 35.87μg/dL, respectively, P = 0.032), and serum Mg levels (1.92 ± 0.18 mg/dL vs. 2.07 ± 0.31 mg/dL, respectively, p = 0.022) was significantly lower in chronic fluorosis patients than in controls. There were no statistically significant
differences between the fluorosis group and control group with respect to serum levels of Na, K, Ca, and P. We concluded that
chronic fluorosis is associated with reduced serum levels of Cu, Zn, and Mg. 相似文献
15.
Kłapcińska B Poprzecki S Danch A Sobczak A Kempa K 《Biological trace element research》2005,108(1-3):1-15
The selenium status and the relationship of whole-blood selenium and plasma homocysteine are reported for healthy human subjects
living in Upper Silesia. A total of 1063 individuals (627 male and 436 female) examined for whole-blood selenium were subdivided
into six groups according to age; the youngest included adolescents (n=143) aged 10–15 yr, and the oldest were centenarians (n=132). The mean Se content was relatively low (62.5±18.4 μg/L), and it tended to be higher in men (65.9±17.2 μg/L) than in
women (57.5±18.9 μg/L). Selenium levels appeared to be age dependent, as the highest values were observed in young and middle-age
adults (21–40 yr), whereas they were significantly lower in adolescents and in the elderly. In more than 40% of apparently
healthy adults (aged 21–69 yr), the Se concentration was within the range 60–80 μg/L (i.e., below the lower limit of the nutritional
adequacy range [80 μg/L]). A significant inverse correlation between whole-blood selenium and plasma total homocysteine was
detected in a smaller population sample of middle-aged and elderly persons (n=204). 相似文献
16.
Hawkes WC Richter BD Alkan Z Souza EC Derricote M Mackey BE Bonnel EL 《Biological trace element research》2008,122(2):107-121
The essential nutrient selenium is required in microgram amounts [recommended dietary allowance (RDA) = 55 μg/day, 699 nmol/day]
and has a narrow margin of safety (upper tolerable intake limit = 400 μg/day, 5 μmol/day). We conducted a randomized placebo-controlled
study of high-selenium yeast, the form used in most supplements (300 μg/day, 3.8 μmol/day), administered to 42 free-living
healthy men for 48 weeks. Dietary intakes of selenium, macronutrients, and micronutrients were not different between groups
and did not change during the study. Supplementation more than doubled urinary selenium excretion from 69 to 160 μg/day (876
to 2,032 nmol/day). Urinary excretion was correlated with recent selenium intake estimated from 3-day diet records: urinary
selenium excretion = 42 μg/day (533 nmol/day) + 0.132 × dietary selenium intake, p < 0.001. Dietary selenium intake was not significantly correlated with the other indicators of selenium status, presumably
because urinary selenium excretion reflected recent intake, and tissue selenium was homeostatically controlled. After 48 weeks
of supplementation, plasma selenium was increased 60% from 142 to 228 μg/l (1.8 to 2.9 μmol/l), and erythrocyte selenium was
approximately doubled from 261 to 524 μg/l (3.3 to 6.6 μmol/l). Selenium concentrations increased more modestly in hair (56%)
and platelets (42%). Platelets were the only blood component in which glutathione peroxidase activity was significantly related
to selenium content. Selenium levels decreased rapidly after the end of supplementation, and there were no significant differences
in selenium status indicators between groups by week 96. The absorption, distribution, and excretion of selenium from high-Se
yeast were similar to selenium in foods. 相似文献
17.
The serum selenium (Se) concentrations were determined to be 105.6±15.6 μg/L (
) and 116.7±18.4 μg/L (
) for the ovarian cancer patients and the control subjects in Singapore, respectively (p<0.0065). When we separated the patients into three age groups, namely <30, 30–50, and >50 yr, the ovarian cancer patients
showed significantly lower mean serum Se levels than the control subjects for the 30–50-yr age group only. However, when the
analysis of variance was used to evaluate the data, the values indicated that the age of the subject did not significantly
affect the serum Se level. Our findings suggest that there is an inverse relationship between serum Se concentration and the
incidence of human ovarian cancer.
A modified simple fluorimetric method for the determination of serum Se concentration is described. The procedure, with a
sensitivity limit of 5 μg/L and percentage recoveries of 96.2–100.7%, requires only 0.2 mL of serum sample. 相似文献
18.
Selenium concentrations in the blood of 112 (56 females and 56 males) normal subjects, from different regions of the Punjab
(Pakistan), have been determined using the technique of inductively coupled plasma-mass spectrometry. The whole blood selenium
concentrations were found to be 452 ± 12 ppb (parts per billion or nano-gram of Se per gram freeze-dried blood or 96 ± 3 μg/L
), with 470 ± 16 ppb (or 100 ± 4 μg/L) in female and 435 ± 16 ppb (or 92 ± 4 μg/L) in male population. Compared with other
populations of the world, these levels are amongst the lowest. 相似文献
19.
Maryam Pakfetrat Leila Malekmakan Mahshid Hasheminasab 《Biological trace element research》2010,137(3):335-339
In this cross-sectional study, selenium (Se) levels in the sera of 35 hemodialysis (HD) patients and 34 patients undergoing
continuous ambulatory peritoneal dialysis (CAPD) for more than 3 months were compared with the serum Se levels of 34 healthy
volunteers. The observed Se levels of 100.8 ± 51.9 μg/L in the sera of the HD patients and of 65.5 ± 32.1 μg/L in the sera
of the CAPD patients were significantly lower than the 134.9 ± 81.2 μg/L of the controls, with p = 0.002 and 0.02, respectively. Furthermore, the Se levels were significantly higher in the HD rather than the CAPD patients
(p = 0.01). In the spent dialysate effluent fluid of 32 of the CAPD patients Se was undetectable, in the remaining two CAPD
patients the Se levels were 1.9 and 4.6μg/l, respectively. The low Se levels of HD and CAPD patients as compared to healthy
persons are attributed to diminished Se retention due to chronic oxidative stress. 相似文献