共查询到20条相似文献,搜索用时 46 毫秒
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Kloosterman WP Tavakoli-Yaraki M van Roosmalen MJ van Binsbergen E Renkens I Duran K Ballarati L Vergult S Giardino D Hansson K Ruivenkamp CA Jager M van Haeringen A Ippel EF Haaf T Passarge E Hochstenbach R Menten B Larizza L Guryev V Poot M Cuppen E 《Cell reports》2012,1(6):648-655
Highlights? Constitutional complex chromosomal rearrangements display unanticipated complexity resembling chromothripsis ? Some chromothripsis rearrangements involve clustered double-stranded DNA breaks ? There exist distinct classes of chromothripsis rearrangements 相似文献
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John P. Rowell Kathryn L. Simpson Katherine Stott Matthew Watson Jean O. Thomas 《Structure (London, England : 1993)》2012,20(12):2014-2024
Highlights? Binding of p53 to its cognate DNA is facilitated by HMGB1 ? The N-terminal region of p53 (residues 38–61; TAD2) interacts with the HMG boxes ? The acidic tail of HMGB1 masks the p53 binding site in the free proteins ? The structure of the A-box/p53(1–93) complex shows that TAD2 acts as an ss-DNA mimic 相似文献
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Denny L. Cottle Kai Kretzschmar Pawel J. Schweiger Sven R. Quist Harald P. Gollnick Ken Natsuga Satoru Aoyagi Fiona M. Watt 《Cell reports》2013,3(2):427-441
Highlights? Myc-induced sebaceous differentiation depends on the androgen receptor and p53 ? The androgen receptor promotes sebocyte differentiation ? Myc induces a p53 response that promotes sebocyte proliferation ? p53 and the androgen receptor are mutually antagonistic 相似文献
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J. Ross Chapman Patricia Barral Jean-Baptiste Vannier Valérie Borel Martin Steger Antonia Tomas-Loba Alessandro A. Sartori Ian R. Adams Facundo D. Batista Simon J. Boulton 《Molecular cell》2013,49(5):858-871
Highlights? RIF1 is essential for 53BP1-dependent CSR and fusion of dysfunctional telomeres ? BRCA1 antagonizes RIF1 in S phase to prevent error-prone repair by toxic NHEJ ? N-terminal phospho-SQ/TQ domain of 53BP1 interacts with and recruits RIF1 to DSBs ? RIF1 and 53BP1 promote NHEJ in G1 by blocking 5′ end resection of DSBs 相似文献
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Cristina Escribano-Díaz Alexandre Orthwein Amélie Fradet-Turcotte Mengtan Xing Jordan T.F. Young Ján Tkáč Michael A. Cook Adam P. Rosebrock Meagan Munro Marella D. Canny Dongyi Xu Daniel Durocher 《Molecular cell》2013,49(5):872-883
Highlights? 53BP1 inhibits BRCA1 recruitment to DSB sites in G1 ? RIF1 is the effector of 53BP1 during DSB repair ? Class-switch recombination requires RIF1 ? RIF1 recruitment to DSB sites in S/G2 is inhibited by BRCA1-CtIP 相似文献
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Highlights? In vitro refolding intermediates are aptly targeted to specific chaperones ? Substrate-chaperone pairing depends on their relative affinity ? Structure of the intermediates play crucial role in precise chaperone targeting ? Substrates may be mistargeted due to large alterations in chaperone molar ratios 相似文献
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Jingling Jin Polina Iakova Meghan Breaux Emily Sullivan Nicole Jawanmardi Dahu Chen Yanjun Jiang Estela M. Medrano Nikolai A. Timchenko 《Cell reports》2013,3(3):831-843
Highlights? Epigenetic alterations cause hepatic steatosis in old mice ? Increase of enzymes of TG synthesis is involved in age-related steatosis ? p300-C/EBPα/β complexes cause activation of enzymes of TG synthesis ? The p300-C/EBP pathway is activated in patients with nonalcoholic fatty liver disease 相似文献
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Isabel Beerman Christoph Bock Brian S. Garrison Zachary D. Smith Hongcang Gu Alexander Meissner Derrick J. Rossi 《Cell Stem Cell》2013,12(4):413-425
Highlights? Locus-specific alterations of the DNA methylome accompany HSC aging ? Methylation changes target genes expressed downstream of HSCs to alter HSC potential ? HSC potential, DNA methylation, and replicative limits depend on divisional history ? Aging and forced proliferation of HSC results in DNA hypermethylation of PRC2 targets 相似文献
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Karin J. Jensen Farshid S. Garmaroudi Jingchun Zhang Jun Lin Seti Boroomand Mary Zhang Zongshu Luo Decheng Yang Honglin Luo Bruce M. McManus Kevin A. Janes 《Cell host & microbe》2013,13(1):67-76
Highlights? Intracellular signaling predicts the fate of coxsackievirus B3 (CVB3)-infected cells ? p38 and ERK signaling pathways are tightly interconnected during CVB3 infection ? CVB3-induced apoptosis of cardiomyocytes is inhibited by ERK5 and ERK1/2 pathways ? CVB3 induces necrosis of cardiomyocytes via p38 activation 相似文献
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Yi Wang Ying Tian Michael P. Morley Min M. Lu Francesco J. DeMayo Eric N. Olson Edward E. Morrisey 《Developmental cell》2013,24(4):345-358
Highlights? Hdac1/2 regulate development of Sox2+ endoderm progenitors ? Bmp4, Rb1, p21, and p16 are direct targets of Hdac1/2 in lung endoderm ? Increased Bmp4 suppresses Sox2 expression in lung endoderm ? Hdac1/2 are required for lung secretory epithelial regeneration 相似文献
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Zhang X Vadas O Perisic O Anderson KE Clark J Hawkins PT Stephens LR Williams RL 《Molecular cell》2011,41(5):567-578
Highlights? Both nSH2 and cSH2 domains of p85 inhibit basal activity of p110β ? p110β/p85β structure shows cSH2 contacts the C terminus of p110β ? Relief of cSH2 inhibition, unlike nSH2, requires extending beyond the pYXXM motif ? p110β C terminus is critical for phosphorylation of lipids and activation by RTKs 相似文献
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Federico González Daniela Georgieva Fabio Vanoli Zhong-Dong Shi Matthias Stadtfeld Thomas Ludwig Maria Jasin Danwei Huangfu 《Cell reports》2013,3(3):651-660
Highlights? Reprogramming increases the level of γH2AX, a marker of DNA DSBs ? Homologous recombination (HR) deficiency impairs reprogramming ? Reprogramming-induced DSBs and HR phenotypes are method-independent ? p53 deletion rescues reprogramming defects in HR-deficient cells 相似文献
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Alexis Kaushansky Albert S. Ye Laura S. Austin Sebastian A. Mikolajczak Ashley M. Vaughan Nelly Camargo Peter G. Metzger Alyse N. Douglass Gavin MacBeath Stefan H.I. Kappe 《Cell reports》2013,3(3):630-637
Highlights? Protein lysate arrays are a useful tool for the study of host–pathogen interactions ? Hepatocyte signaling is substantially perturbed in response to Plasmodium infection ? Regulation of host p53 is required for efficient Plasmodium development ? Elevated levels of p53 eliminate Plasmodium parasites during the liver stage 相似文献
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Anne-Laure Huber Justine Lebeau Patricia Guillaumot Virginie Pétrilli Mouhannad Malek Julien Chilloux Frédérique Fauvet Léa Payen Alain Kfoury Toufic Renno Eric Chevet Serge N. Manié 《Molecular cell》2013,49(6):1049-1059
Highlights? Transformation-associated glucose shortage triggers ER stress ? The ER stress acts as barrier to malignancy by triggering UPR-dependent apoptosis ? p58IPK expression removes the UPR barrier by attenuating its PERK-CHOP branch ? This adaptive mechanism enables implementation of UPR cytoprotective features 相似文献