共查询到20条相似文献,搜索用时 20 毫秒
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Li Z Lai Z Ya K Fang D Ho YW Lei Y Ming QZ 《Journal of cellular and molecular medicine》2008,12(2):569-579
Transferrin and transferrin receptor are two key proteins of iron metabolism that have been identified to be hypoxia-inducible genes. Divalent metal transporter 1 (DMT1) is also a key transporter of iron under physiological conditions. In addition, in the 5' regulatory region of human DMT1 (between -412 and -570), there are two motifs (CCAAAGTGCTGGG) that are similar to hypoxia-inducible factor-1 (HIF-1) binding sites. It was therefore speculated that DMT1 might also be a hypoxia-inducible gene. We investigated the effects of hypoxia and hypoxia/re-oxygenation on the expression of DMT1 and the content of HIF-1alpha in HepG2 cells. As we expected, a very similar tendency in the responses of the expression of HIF-1alpha, DMT1+IRE (iron response element) and DMT1-IRE proteins to chemical (CoCl(2)) or physical hypoxia was observed. A highly significant correlation was found between the expression of DMT1 proteins and the contents of HIF-1 in hypoxic cells. After the cells were exposed to hypoxia and subsequent normoxia, no HIF-1alpha could be detected and a significant decrease in DMT1+IRE expression (P<0.05), but not in DMT1-IRE protein (versus the hypoxia group), was observed. The findings implied that the HIF-1 pathway might have a role in the regulation of DMT1+IRE expression during hypoxia. 相似文献
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Takahashi Y Takahashi S Shiga Y Yoshimi T Miura T 《The Journal of biological chemistry》2000,275(19):14139-14146
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Makino Y Uenishi R Okamoto K Isoe T Hosono O Tanaka H Kanopka A Poellinger L Haneda M Morimoto C 《The Journal of biological chemistry》2007,282(19):14073-14082
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Obach M Navarro-Sabaté A Caro J Kong X Duran J Gómez M Perales JC Ventura F Rosa JL Bartrons R 《The Journal of biological chemistry》2004,279(51):53562-53570
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Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide 总被引:13,自引:0,他引:13
Kimura H Weisz A Ogura T Hitomi Y Kurashima Y Hashimoto K D'Acquisto F Makuuchi M Esumi H 《The Journal of biological chemistry》2001,276(3):2292-2298
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