The E protein-TCF1 axis controls γδ T cell development and effector fate

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Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture,phosphorylation, and ubiquitylation

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Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium

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How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor

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Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

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Transcriptional modification of host cells harboring Toxoplasma gondii bradyzoites prevents IFN gamma-mediated cell death

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Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions

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TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease

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Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones

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Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration

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Hydathode immunity protects the Arabidopsis leaf vasculature against colonization by bacterial pathogens

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Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILK

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Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain

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Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells

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Alternating sources of perisomatic inhibition during behavior

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From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease

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Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis

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Organ-specific COP1 control of BES1 stability adjusts plant growth patterns under shade or warmth

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A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin

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Follicular regulatory T cells produce neuritin to regulate B cells

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