15th International Cancer Congress

Meeting announcement

15th International Cancer Congress     

13th International Congress of Biochemistry

Cytochrome caa₃ (cytochrome oxidase) from the thermophilic bacterium PS3 can exhibit full catalytic activity in the presence of ascorbate and TMPD or other electron donors and in the absence of added soluble c-type cytochromes. It appears to possess only a low-affinity and not a high-affinity site for the soluble cytochromes. Proteoliposomal cytochrome caa₃ develops an effective membrane potential in the presence of ascorbate and TMPD or PMS, in the absence of added soluble cytochrome c. Reduction of the a₃ centre is blocked in the presence of cyanide. During reductive titrations of the cyanide-inhibited enzyme, electrons initially equilibrate among three centres, the c haem, the a haem and one of the associated Cu atoms. During steady-state turnover, electrons probably enter the complex via the bound c haem; the a haem and perhaps an associated Cu_A atom are reduced next. It is concluded that, despite its size and hydrophobic association with the aa₃ complex, the haem c-containing subunit can behave in an analogous way to that of mammalian cytochrome c, bound at the high-affinity site of the eucaryotic enzyme.     

第20届国际生物化学与分子生物学联盟代表大会暨学术大会和第11届亚洲大洋州生物化学家与分子生物学家学术大会信息

第20届国际生物化学与分子生物学联盟代表大会暨学术大会和第11届亚洲大洋州生物化学家与分子生物学家学术大会定于2006年6月18-23日在日本京都召开（6月16—17日召开青年科学家论坛）,学会希望各位会员和从事生物化学和分子生物学及相关学科的科学家积极投稿和参加会议。可在网上直接投稿,网址：http：///www．conger．co．jp／iubmb／,投稿日期2005年12月5日开始,2006年1月31日截止。