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1.
Macrolide use in the previous years is associated with failure to eradicate Helicobacter pylori with clarithromycin‐containing regimens 下载免费PDF全文
Pablo Muñoz‐Gómez Junior Alexander Jordán‐Castro María Abanades‐Tercero José Javier Blanco‐González Eva María Andrés Esteban Julio Valle‐Muñoz 《Helicobacter》2018,23(1)
Background
There is some evidence that prior use of macrolide antibiotics is a useful predictor of the likelihood of standard triple therapy failure in Helicobacter pylori eradication. In this study, we have evaluated whether previous intake of macrolides correlates with failure to eradicate H. pylori using two different first‐line clarithromycin‐containing regimens.Materials and Methods
Retrospective study of 212 patients with H. pylori infection treated with one of two first‐line clarithromycin‐containing regimens: 108 patients treated with triple therapy for 10 days and 104 patients treated with concomitant therapy for 10 days. The intake of macrolides (clarithromycin, azithromycin, and other macrolides) prior to the eradication therapy was obtained from the electronic medical record, which contains information regarding all the medication prescribed to the patients since the year 2004.Results
One hundred of 212 patients (47.2%) had received at least one treatment with macrolides during the years prior to the eradication therapy. H. pylori eradication rates were significantly lower in patients with previous use compared to patients without previous use of macrolides, both with triple therapy (60.8% vs 92.9%; P < .0001) and with concomitant therapy (85.7% vs 98.2%; P = .024).Conclusions
Previous use of macrolides correlates with a low H. pylori eradication rate with triple and concomitant clarithromycin‐containing regimens. In addition, our study shows that in patients without previous use of macrolides, triple therapy achieves per‐protocol eradication rates over 90%. 相似文献2.
3.
Chia-Huei Lee Chih-Min Liu Chun-Chiang Wen Shun-Min Chang Hai-Gwo Hwu 《Journal of biomedical science》2010,17(1):2
Background
Schizophrenia is a complex disorder with involvement of multiple genes. 相似文献4.
Elke EM Brouwers Alwin DR Huitema Jos H Beijnen Jan HM Schellens 《BMC clinical pharmacology》2008,8(1):7
Background
The aim of this study was to evaluate long-term platinum retention in patients treated with cisplatin and oxaliplatin. 相似文献5.
Visvanathan S Rahman MU Keystone E Genovese M Klareskog L Hsia E Mack M Buchanan J Elashoff M Wagner C 《Arthritis research & therapy》2010,12(6):R211
Introduction
The goal of this study was to identify serum markers that are modulated by treatment with golimumab with or without methotrexate (MTX) and are associated with clinical response. 相似文献6.
Morgenstern B Prohaska SJ Pöhler D Stadler PF 《Algorithms for molecular biology : AMB》2006,1(1):6-12
Background
Automated software tools for multiple alignment often fail to produce biologically meaningful results. In such situations, expert knowledge can help to improve the quality of alignments. 相似文献7.
Andreas Prlić Thomas A Down Eugene Kulesha Robert D Finn Andreas Kähäri Tim JP Hubbard 《BMC bioinformatics》2007,8(1):333
Background
The Distributed Annotation System (DAS) is a network protocol for exchanging biological data. It is frequently used to share annotations of genomes and protein sequence. 相似文献8.
Claudia NCD Lemos Fernando M Reis Guilherme N Pena Laila C Silveira Aroldo F Camargos 《Reproductive biology and endocrinology : RB&E》2010,8(1):51
Background
Reproductive function following chemotherapy is of increasing importance given that survival rates are improving. We assessed whether a gonadotropin-releasing hormone antagonist (GnRHant; cetrorelix) could promote ovarian protection against damage due to chemotherapy. 相似文献9.
Bernal M Concha A Sáenz-López P Rodríguez AI Cabrera T Garrido F Ruiz-Cabello F 《Cancer immunology, immunotherapy : CII》2011,60(6):869-882
Purpose
To analyze the correlation of genomic instability with leukocyte infiltrate in gastrointestinal carcinomas (GIACs) and with tumor immunogenicity, e.g., HLA class I cell surface expression defects and galectin-3 and PDL-1 expression. 相似文献10.
Kaya T Ishizawa Hiroaki Kumano Atsushi Sato Hiroshi Sakura Yasuhiko Iwamoto 《BioPsychoSocial medicine》2010,4(1):1
Background
This study was performed to examine whether patients with type 2 diabetes have cognitive deficits associated with the prefrontal cortex (PFC). 相似文献11.
Reidun Heiene Veronica Kristiansen Jon Teige Johan Høgset Jansen 《Acta veterinaria Scandinavica》2007,49(1):13
Background
Age-related changes in renal histomorphology are described, while the presence of glomerulonephritis in dogs with pyometra is controversial in current literature. 相似文献12.
Karen Goossens Ann Van Soom Mario Van Poucke Leen Vandaele Jo Vandesompele Alex Van Zeveren Luc J Peelman 《BMC developmental biology》2007,7(1):64
Background
Normal preimplantation embryo development encompasses a series of events including first cleavage division, activation of the embryonic genome, compaction and blastocyst formation. 相似文献13.
Jonathan CM Clark Toru Akiyama Crispin R Dass Peter FM Choong 《Cancer cell international》2010,10(1):20
Background
Chondrosarcoma responds poorly to adjuvant therapy and new, clinically relevant animal models are required to test targeted therapy. 相似文献14.
Background
We compared two methods of rooting a phylogenetic tree: the stationary and the nonstationary substitution processes. These methods do not require an outgroup. 相似文献15.
Background
The objective was to identify separate cognitive domains in the standard assessment tools (MMSE, ADAS-Cog) and analyze the process of decline within domains during three years in Alzheimer's disease (AD) patients with donepezil treatment. 相似文献16.
Malgorzata Szczepańska Przemyslaw Wirstlein Jana Skrzypczak Pawe? P Jagodziński 《Reproductive biology and endocrinology : RB&E》2012,10(1):1
Background
A decrease in HOXA11 expression in eutopic mid-secretory endometrium has been found in women with endometriosis-associated infertility. 相似文献17.
Tooth loss and its relationship with protein intake by elderly Brazilians—A structural equation modelling approach 下载免费PDF全文
Objective
This study aimed at assessing the relationship between self‐perceived tooth loss and wearing dentures, on the one hand, and the consumption of protein, on the other hand, among the elderly population of Botucatu, SP. Food consumption tends to decrease with ageing, especially protein intake, and one of the causes could be the precariousness of oral health. Several risk factors associated with deficient dietary protein intake have been identified, namely greater physical dependence, reduced caloric intake and food insecurity, but no studies have analysed whether tooth loss and prostheses interfere with protein intake.Methods
An interview was conducted among 365 elderly individuals, in which we examined oral health‐related quality of life (OHRQoL) as the only latent variable, in a 24‐hour nutritional assessment dietary recall repeated 3 times, conducted in person by a trained nutritionist and also performed an analysis of nutritional needs using the Nutrition Data System Research (NDSR) Program.Results
The structural equation model, performed using Stata v.14, showed that lack of teeth (standardised coefficient [SC] = 0.21, P < .001), and prosthesis use (SC = ?0.21, P < .001) was associated with OHRQoL. Lack of teeth had a direct effect on the consumption of animal protein (SC = 0.08, P = .02), a strong total effect on animal protein intake (SC = 0.51, P = .04) and a medium effect on total protein intake (SC = 0.20, P = .03), adjusted for confounders (depression and medical problems).Conclusion
Tooth loss had a strong and significant total effect on animal protein intake and a medium effect on total protein intake among elderly Brazilians. 相似文献18.
Halvor Naess Solveig Glad Anette Storstein Christine H Rinaldo Sverre J Mørk Kjell-Morten Myhr Hans Hirsch 《BMC neurology》2010,10(1):32
Background
To report the clinical course of PML in an apparently immunocompetent patient treated with cidofovir. 相似文献19.
Antibiotics resistance of Helicobacter pylori in children with upper gastrointestinal symptoms in Hangzhou,China 下载免费PDF全文
Background
The decreasing eradication rate of Helicobacter pylori is mainly because of the progressive increase in its resistance to antibiotics. Studies on antimicrobial susceptibility of H. pylori in children are limited. This study aimed to investigate the resistance rates and patterns of H. pylori strains isolated from children.Materials and Methods
Gastric mucosa biopsy samples obtained from children who had undergone upper gastrointestinal endoscopy were cultured for H. pylori, and susceptibility to six antibiotics (clarithromycin, amoxicillin, gentamicin, furazolidone, metronidazole, and levofloxacin) was tested from 2012‐2014.Results
A total of 545 H. pylori strains were isolated from 1390 children recruited. The total resistance rates of H. pylori to clarithromycin, metronidazole, and levofloxacin were 20.6%, 68.8%, and 9.0%, respectively. No resistance to amoxicillin, gentamicin, and furazolidone was detected. 56.1% strains were single resistance, 19.6% were resistant to more than one antibiotic, 16.7% for double resistance, and 2.9% for triple resistance in 413 strains against any antibiotic. And the H. pylori resistance rate increased significantly from 2012‐2014. There was no significant difference in the resistance rates to clarithromycin, metronidazole, and levofloxacin between different gender, age groups, and patients with peptic ulcer diseases or nonulcer diseases.Conclusions
Antibiotic resistance was indicated in H. pylori strains isolated from children in Hangzhou, and it increased significantly during the 3 years. Our data strongly support current guidelines, which recommend antibiotic susceptibility tests prior to eradication therapy. 相似文献20.