共查询到20条相似文献,搜索用时 312 毫秒
1.
Higashi TL Ikeda M Tanaka H Nakagawa T Bando M Shirahige K Kubota Y Takisawa H Masukata H Takahashi TS 《Current biology : CB》2012,22(11):977-988
Highlights? XEco2 loading and cohesin acetylation require pre-RC assembly but not DNA synthesis ? Two N-terminal motifs in XEco2 are essential for XEco2 loading and cohesion ? The PIP box in XEco2 contributes to cohesion ? Interaction of acetylated cohesin with DNA is stabilized after DNA replication 相似文献
2.
Eva M. Huber Daniel H. Scharf Peter Hortschansky Michael Groll Axel A. Brakhage 《Structure (London, England : 1993)》2012,20(10):1757-1768
Highlights? CBC binds to the minor groove of the DNA and bends it in a nucleosome-like manner ? Interactions of subunit HapB with DNA explain the sequence specificity of the CBC ? Anchor A of HapB tethers the CBC to the CCAAT box by minor groove widening ? Interactions of the CBC with the histones H3/H4 of the nucleosome are modeled 相似文献
3.
Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression 相似文献
4.
Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer
Highlights? C13 RNA aptamer variants stabilize GRK2 in a unique and remodeled conformation ? The aptamer positions an adenine nucleotide into the ATP-binding pocket of GRK2 ? Basic residues on an exterior surface of GRK2 facilitate aptamer binding ? The terminal stem of the aptamer indirectly contributes to affinity 相似文献
5.
Yucai Wang Justin W. Leung Yingjun Jiang Megan G. Lowery Huong Do Karen M. Vasquez Junjie Chen Weidong Wang Lei Li 《Molecular cell》2013,49(5):997-1009
Highlights? FANCM and FAAP24 exhibit nonepistatic functions in cell survival upon DNA damage ? FAAP24 confers unique lesion specificity in DNA damage cell-cycle checkpoint ? FANCM translocase activity is involved in recombination-independent ICL repair 相似文献
6.
Yi Wang Ying Tian Michael P. Morley Min M. Lu Francesco J. DeMayo Eric N. Olson Edward E. Morrisey 《Developmental cell》2013,24(4):345-358
Highlights? Hdac1/2 regulate development of Sox2+ endoderm progenitors ? Bmp4, Rb1, p21, and p16 are direct targets of Hdac1/2 in lung endoderm ? Increased Bmp4 suppresses Sox2 expression in lung endoderm ? Hdac1/2 are required for lung secretory epithelial regeneration 相似文献
7.
Highlights? The 3D structure of PKCι in complex with a peptide from Par-3 is determined ? PKCι does not need phosphorylation of Thr402 in its activation loop for its activity ? aPKCs do not need a priming kinase for their activations ? The PKCι/Par-3 structure reveals a unique substrate recognition patterns for aPKCs 相似文献
8.
Nichole O'Connell Scott R. Nichols Ewald Heroes Monique Beullens Mathieu Bollen Wolfgang Peti Rebecca Page 《Structure (London, England : 1993)》2012,20(10):1746-1756
Highlights? The first structure of a nuclear PP1 holoenzyme, NIPP1:PP1 ? The NIPP1 helix defines a unique interaction site on PP1 ? Identification of a common PP1-binding pocket, the ΦΦ motif-binding pocket ? Explains the mechanism of nuclear substrate selection by PP1 相似文献
9.
Highlights? Structures of β1AR bound to the biased agonists bucindololol and carvedilol ? The biased agonists form unique contacts with β1AR not seen with other antagonists ? The structures explain the pharmacological differences in the Arg389Gly polymorphism 相似文献
10.
Li A Ma Y Yu X Mort RL Lindsay CR Stevenson D Strathdee D Insall RH Chernoff J Snapper SB Jackson IJ Larue L Sansom OJ Machesky LM 《Developmental cell》2011,21(4):722-734
Highlights? Rac1 and the Scar/WAVE complex drive pseudopod-based motility of melanoblasts ? Rac1-depleted melanoblasts move using unique actin-based stubs and not blebs ? Rac1 controls pseudopod frequency but is dispensable for pseudopod formation ? Loss of Rac1 delays melanoblast cell-cycle progression and cytokinesis 相似文献
11.
Frankenstein Z Sperling J Sperling R Eisenstein M 《Structure (London, England : 1993)》2012,20(6):1097-1106
Highlights? We present a computational procedure for fast matching of thousands of conformers ? We obtained a unique model localizing the snRNPs within the native spliceosome ? The 5 snRNPs are accommodated mostly within the large subunit of the spliceosome ? The large spliceosomal cavity emerges as the site of mRNA binding and splicing 相似文献
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13.
Josefin Fernius Olga O. Nerusheva Stefan Galander Flavia de Lima Alves Juri Rappsilber Adele L. Marston 《Current biology : CB》2013,23(7):599-606
Highlights? Cohesin is required for the association of its loader, Scc2/4, with centromeres ? The Ctf19 kinetochore subcomplex targets the loader to centromeres ? Centromere-loaded cohesin ensures pericentromeric cohesion establishment ? Cohesin ring formation triggers cohesin loading via Scc2/4 相似文献
14.
Jaehoon Kim Jung-Ae Kim Robert K. McGinty Uyen T.T. Nguyen Tom W. Muir C. David Allis Robert G. Roeder 《Molecular cell》2013,49(6):1121-1133
Highlights? H2B ubiquitylation directly stimulates H3K4 methylation by the yeast Set1 complex ? Swd2 is not directly required for the H3K4 methylation activity of the yeast Set1 complex ? The Set1 n-SET domain plays a critical role in H2Bub-dependent H3K4 methylation ? Spp1 is conditionally involved in n-SET- and H2Bub-dependent H3K4 methylation 相似文献
15.
Marko Mocibob Nives Ivic Marija Luic Ivana Weygand-Durasevic 《Structure (London, England : 1993)》2013,21(4):614-626
Highlights? The crystal structure of the aa:CP ligase in complex with carrier protein was solved ? The interaction relies on the idiosyncratic α-helix of the aa:CP ligase ? The complex represents a unique mode of carrier protein recognition and binding ? The mechanism of amino acid attachment to carrier protein is discussed 相似文献
16.
Mario Rossi Shanshan Duan Yeon-Tae Jeong Moritz Horn Anita Saraf Laurence Florens Michael P. Washburn Adam Antebi Michele Pagano 《Molecular cell》2013,49(6):1159-1166
Highlights? FBXO11 targets CDT2, a CRL4 substrate receptor, for proteasomal degradation ? CDK-mediated phosphorylation of CDT2 degron inhibits recognition by FBXO11 ? FBXO11-mediated degradation of CDT2 controls the timing of cell-cycle exit ? FBXO11-CDT2 functional interaction is evolutionary conserved from worms to humans 相似文献
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18.
Rui Fang Fei Chen Zhenghong Dong Di Hu Andrew J. Barbera Erin A. Clark Jian Fang Ying Yang Pinchao Mei Michael Rutenberg Ze Li Ying Zhang Youwei Xu Huirong Yang Ping Wang Matthew D. Simon Qiongjie Zhou Jing Li Yujiang Geno Shi 《Molecular cell》2013,49(3):558-570
Highlights? Identifying NPAC as a novel LSD2 cofactor stimulating H3K4 demethylation ? Structure determination of LSD2 alone or in complex with NPAC and histone H3 peptide ? Defining the key NPAC residues essential for its intrinsic LSD2 cofactor activity ? Establishing a molecular model for how a cofactor regulates histone demethylation 相似文献
19.
Eguchi K Manabe I Oishi-Tanaka Y Ohsugi M Kono N Ogata F Yagi N Ohto U Kimoto M Miyake K Tobe K Arai H Kadowaki T Nagai R 《Cell metabolism》2012,15(4):518-533
Highlights? Palmitate induces β cell dysfunction by activating inflammatory processes in islets ? β cells sense palmitate via the TLR4 pathway and recruit M1 macrophages to islets ? M1 macrophages play a pivotal role in palmitate-induced β cell dysfunction ? M1 macrophages and inflammation also play a role in β cell dysfunction in T2D models 相似文献
20.
Mark R. Morgan Hellyeh Hamidi Mark D. Bass Stacey Warwood Christoph Ballestrem Martin J. Humphries 《Developmental cell》2013,24(5):472-485
Highlights? c-Src phosphorylates syndecan-4 in response to extracellular stimuli ? Syndecan-4 phosphorylation and engagement regulate Arf6 activity ? Syndecan-4-mediated Arf6 activity regulates differential integrin recycling ? Syndecan-4-mediated integrin recycling controls FA dynamics and cell migration 相似文献