Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer

Background  

Urodele amphibians like the axolotl are unique among vertebrates in their ability to regenerate and their resistance to develop cancers. It is unknown whether these traits are linked at the molecular level.     

Analyses of domains and domain fusions in human proto-oncogenes

Background  

Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers.     

Application of methods of identifying receptor binding models and analysis of parameters

Background  

Possible methods for distinguishing receptor binding models and analysing their parameters are considered.     

Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset

Background  

As more methods are developed to analyze RNA-profiling data, assessing their performance using control datasets becomes increasingly important.     

The exon context and distribution of Euascomycetes rRNA spliceosomal introns

Background  

We have studied spliceosomal introns in the ribosomal (r)RNA of fungi to discover the forces that guide their insertion and fixation.     

The parenting attitudes and the stress of mothers predict the asthmatic severity of their children: a prospective study

Objective  

To examine relationships between a mother's stress-related conditions and parenting attitudes and their children's asthmatic status.     

Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis

Introduction  

The aim of this study was to examine the serum levels of S100 proteins and to evaluate their role in patients with recent-onset rheumatoid arthritis (RA).     

Different glycosylation of cadherins from human bladder non-malignant and cancer cell lines

Background  

The aim of the present study was to determine whether stage of invasiveness of bladder cancer cell lines contributes to alterations in glycan pattern of their cadherins.     

Reduced complexity of activity patterns in patients with Chronic Fatigue Syndrome: a case control study

Objective  

We examined developmental aspects of the emotional awareness of adolescents by evaluating their responses to a self-reported questionnaire based on the Toronto Alexithymia Scale-20 (TAS-20).     

Discovery of protein-protein interactions using a combination of linguistic,statistical and graphical information

Background  

The rapid publication of important research in the biomedical literature makes it increasingly difficult for researchers to keep current with significant work in their area of interest.     

Deciphering protein function during mitosis in PtK cells using RNAi

Background  

Studying mitosis requires a system in which the dramatic movements of chromosomes and spindle microtubules can be visualized. PtK cells, due to their flat morphology and their small number of large chromosomes, allow microscopic visualizations to be readily performed.     

Molecular and functional characterization of voltage-gated sodium channels in human sperm

Background  

We have investigated the expression of voltage-gated sodium channels in human spermatozoa and characterized their role in sperm motility.     

Predicting <Emphasis Type="Italic">β</Emphasis>-turns and their types using predicted backbone dihedral angles and secondary structures

Background  

β-turns are secondary structure elements usually classified as coil. Their prediction is important, because of their role in protein folding and their frequent occurrence in protein chains.     

Actomyosin contractility controls cell surface area of oligodendrocytes

Background  

To form myelin oligodendrocytes expand and wrap their plasma membrane multiple times around an axon. How is this expansion controlled?     

TabSQL: a MySQL tool to facilitate mapping user data to public databases

Background  

With advances in high-throughput genomics and proteomics, it is challenging for biologists to deal with large data files and to map their data to annotations in public databases.     

Single-step autoantibody profiling in antiphospholipid syndrome using a multi-line dot assay

Introduction  

Diagnosis of antiphospholipid syndrome (APS) still remains a laboratory challenge due to the great diversity of antiphospholipid antibodies (aPL) and their significance regarding APS-diagnostic criteria.     

A eukaryotic initiation factor 5C is upregulated during metamorphosis in the cotton bollworm, Helicoverpa armigera

Background  

The orthologs of eukaryotic initiation factor 5C (eIF5C) are essential to the initiation of protein translation, and their regulation during development is not well known.     

Heritability patterns in hand osteoarthritis: the role of osteophytes

Introduction  

The objective of the present study was to assess heritability of clinical and radiographic features of hand osteoarthritis (OA) in affected patients and their siblings.     

<Emphasis Type="Italic">Leptospira</Emphasis> seroprevalence and associations between seropositivity,clinical disease and host factors in horses

Background  

A cross-sectional study was carried out to determine the seroprevalence of different serovars of Leptospira spp. and their association with clinical disease and host factors in Swedish horses.