Chronologie de l’art Mégalithique ibérique : C et contextes archéologiques

From the beginning of our investigation we found the necessity of locating the Megalithic Iberian art in the chronology that came off of the well-known data in the peninsula at the end of the 1980s and of those that manifested the Atlantic long sequences. Then, we argue the dates obtained in the deposits of decorated dolmens to endorse the chronological similarity between architectures and decorations. To it, we could add decorations in the nonvisible area of some slabs that they even aimed a bigger antiquity. With that material, we organize our first chronological proposal for the Megalithic Iberian art, in which we assumed dates of fifth millennium lime BC for the oldest decorations, in consonance with the construction of the first megaliths. Moreover, it would be right so much in the supposedly classic areas as in the less favoured sectors for the investigation: the Interior, the South and the West of the Iberian peninsula. In successive works we are configuring a hypothesis on its development and chronology that offers more and more confirmations. The documentation of AMS dates on megalithic paintings, a unique case in the megalithic European art, comes to consolidate the chronology of the megalithic Iberian art. With all the data obtained in the last twenty years, we are arrived to the moment for establishing a sequence to adjust their times, to value complex situations in the decoration of the monuments and to confirm a long chronology that arrives practically as a residual way to Iron Age.     

Nouvelle approche de l’art rupestre de l’Atlas saharien : les figurations de la période tardive

Figurations in Atlas have been studied numerous times, namely by Flamand and Frobenius between 1891 and 1914, by Vaufrey in 1939 and by Lhote between 1955 and 1970. And finally there were Iliou’s¹ and Hachid’s theses in the 1980s and Amara’s thesis in 2001. The study of the Atlas figurations discovered since 1847 brought new data on the engravings from the recent period. The originality of the engravings lies in the appearance of new themes, which had been unknown until yet. The presence of metal weapons figures enriches the records of the Atlas rock Art. The alphabetical signs, another new theme, give an identity to this Art. The work undertaken in this vast region raises the problem of the persistency of the Neolithic culture. All the figurations show some aspects of the evolution, which become permanent, mostly at the end of the recent period.     

Application d'une méthode d'analyse du territoire à partir de la situation des marqueurs graphiques à l'intérieur de la Péninsule Ibérique : le Tage International

This paper, analyses the graphic evidences of the boundaries of Tagus between Spain and Portugal from the perspective of the model defended by our team. This model proposes the existence of the relationship between graphic markers: paintings, engravings in the open air, decorations over dolmens and menhirs, understood as a compact ideological group fixed in the organization social system of European producing people and metallurgical that occupying this landscape. This argument attempt to verify the possibilities of applying a pre-defined model in an area in which have been developed investigation models, focused to study megalithic monuments, menhirs, habitational areas, paints and engravings that shows symbolic expressions of the tradition to justify the property of rich areas in natural resources in what metallurgical have a remarkable importance.     

Cancer de prostate métastatique résistant à la castration : le point de vue de l’oncologue médical

Most of patient suffering from a prostate cancer will develop a castration resistance. In this common and clinically challenging situation, chemotherapy was not considered very useful until mid 2000s. Docetaxel is now recognized as a standard of care, improving overall survival and quality of life. However, new drugs are needed. Two compounds (cabazitaxel and abiraterone) are now underway to official registration and an autologous vaccin strategy (Sipuleucel) demonstrated a benefit in survival. Based on a greater knowledge of biology, many other agents are currently under development, such as new specific peripheral anti-androgens, anti-angiogenic therapies, or proteasome inhibitors. All these new drugs are promising and may provide more efficient therapies against this incurable disease in the near future.     

Sur l’origine bactérienne et fongique de la pigmentation de l’Ammonitico Rosso (Jurassique, région de Vérone, Italie du nord)

Fourteen sections in the Ammonitico Rosso Veronese (Callovian to Tithonian, Trento altipiano) disclose the presence of diverse facies ranging from pelagic to outer platform. In spite of this diversity, red limestones are present at different levels. Many microfacies are similar to those observed in other Paleozoic and Mesozoic red carbonates with an abundance of hematitic bioconstructions. We therefore postulate that the origin of the pigmentation is similar in all the studied cases and due to the activity of iron-oxidizing bacteria. Nevertheless, 2 notable differences are observed: the presence in the Ammonitico Rosso of manganese and the existence of in situ bacterial-fungal mats in the matrix. These “algal” mats can represent up to 20% of the sediment. Their excellent preservation (absence of packing down or crushing) is due to the slow sedimentation rate of the pelagic sediments or of the hardgrounds.     

Les principales étapes de l’occupation humaine en bordure de l’Himalaya occidentale

Lithic industries attest that Western Himalayas, Hindu Kush and Pamir as well as the sub-Himalayan belt that is the Siwalik range, were inhabited during the prehistoric times. However, in thin transition zone between plains and high mountains, distinction is to be kept between low-middle altitude regions and high altitude regions (above 2000 m). In the former regions, the first human occupation tenuously appears around 2 Ma. In the Middle Pleistocene, the Lower Palaeolithic industries belong to two technological facies, the Acheulian and the Early Soanian. In the North-Western Siwaliks, the Soanian occurs in plenty on the river terraces, which were all built after 0.4 Ma, and the Acheulian appears between 0.5 and 0.7 Ma. The Middle Palaeolithic is still rich in cobble tools and therefore named Late Soanian. The Upper Palaeolithic is missing, perhaps due to climatic factors and the Neolithic is characterised by polished axes/adzes, but actually many of the cobble tools usually considered as Early Soanian may well belong to the cobble tool technical tradition common in South-East Asia during the Late Pleistocene and Early Holocene. In the north of the mountain range, the entire Palaeolithic sequence yielded by the loess in Southern Tajikistan is characterised, right from the late Lower Pleistocene, by lithic industries mainly compose of flakes, sometimes with cobble tools. In the high altitude zones, prehistoric sites are unknown before the Holocene and therefore they are contemporaneous with the Neolithic but some technological facies display particular features. The question is to know whether the originality of the industries, observed at different periods of time, is linked to techno-cultural adaptations to particular environments or to the isolation of the mountain populations.     

Les industries magdaléniennes de l’Ardèche (France) dans le contexte du bassin méditerranéen

Ardèche, a department of Rhone Alpes region, is rich in prehistoric sites belonging to a very large chronological period dated back to 350?000 years ago. But, the prehistory of the region has been unknown for a long time, mainly, because of its distance from traditional centres of research. Jean Combier, in his abstract dated 1967, defined for the first time Upper Palaelolithic stages: only towards the acquisition of new data, we are now able to suggest a new evolution for the Magdalenian from its origins to the Alleröd climatic episod. To define Ardèche originality within the Magdalenian context, we have compared its lithic industries with those of the Adaouste Cave oriental sites, the Cornille rock shelter and of the Gazel cave in the Aude western part. Ardèche Magdalenian dwelling is peculiar compared to the South West of France. Badegoulian has been substituted by a Mediterranean Facies culture rich in bladelets, the Salpestrian. This facies limited in its geographic extention to Gard and Ardèche, evolves gradually in situ gaining Magdalenian elements (such as backed bladelets and dihedral burins) giving birth to the transitory lithic complex of Huguenots and Baume d’Oullins Cave. An established Magdalenian is certified in the Blanchisserie camp, within a cold climatic context dated back to circa 16?000 years ago. Although the lithic industry is dominated by dihedral burins and backed bladeletse it is also characterised by some archaic features (such as keel endscrapers, transverse burins and scalene bladelets). The upper Magadalenian with bone harpoons appears soon in our region, in the Colombier rock shelter, in a fairly temperate climatic context dated according to 14C back to circa 14?000 BP. We could identify six stages within the evolution of this Upper Magdalenian.which are attested in the Colombier, Ebbou and Deux Avens Caves and in the Colombier rock shelter that has been occupied during several periods. The Magdalenian gradually changed loosing his most typical elements, the bladelets and burins supremacy has been substituted by Azilian elements (such as short endscrapers and curved backed points). But even if the Azilian process happens very early (before 12?500 BP) the Magdalenian, in its fundamental features, never disappears completely and it has never been substituted by classic Azilian. After Alleröd appears a culture characterised by the recovery of Magdalenian features similar to the Epimagdalenian defined by D. Sacchi in Gazel. The described evolution can be compared, as regard to its upper stages, to that of several sites of Rhone region as well as of the North West of France, which allow to define a culturally homogeneous province having the Rhone corridor with Ardèche as its Southern border. At the end of Palaeolithic this province broke up and Ardèche opened to the South and the Mediterranean from where seems to come the retouched large blade facies and endscrapers attested by the Colombier rock shelter dating back to 12?150 BP.     

Le site des Vachons : étude de la partie gravettienne de la collection de l’IPH

This article firstly summarizes the process of study of an old collection, which had not been considered since the excavations at the site Les Vachons, started before 1914 and completed around 1939. The studied collection of J. Coiffard, both excavator and inventor of this site, includes four-fifths of the artefacts because, in 1940, he donated approximately one fifth to the Eyzies Museum. For his part, J. Bouyssonie who participated in the excavations for 3 years gave the major part of his own collection to the Archaeological Society of Charentes Angouleme where its condition makes it difficult to analyze. Despite these restrictions, based on statistical comparisons with counts many other sites, I came to the conclusion that the top three layers of Les Vachons are a confirmation of the Gravettian model, developed by B. Bosselin and F. Djindjian through their factor analysis. This model seems much better suited to the stratigraphy of Les Vachons, than all assumptions made by previous analysts in their attempt to bring the industries from the three layers in what remains from the Peyrony model.     

Apport de l’imagerie hybride TEMP-TDM dans le suivi d’un cancer différencié de la thyroïde

In the management of patients with differentiated thyroid cancer (DTC), abnormalities detected on planar whole body scan and ¹³¹I-SPECT are difficult to interpret because of a lack of anatomical landmarks and limited specificity. Integrated ¹³¹I-SPECT-CT imaging has an additional value for characterization of equivocal tracer uptake seen on planar imaging as well as for precise localization. We illustrate through an observation the incremental diagnostic value of ¹³¹I-SPECT-CT images in the diagnosis of a cervical lymph node mimicking a physiological uptake on planar views. A 35-year-old Tunisian female was followed for papillary thyroid carcinoma, for which she underwent total thyroidectomy and iratherapy. Three years after a complete remission, the thyroglobulin (Tg) level on TSH stimulation increased. Diagnostic planar images with ¹³¹I did not disclose any obvious pathological foci. Furthermore, we noticed an increased ¹³¹I-uptake in the left sub-mandibulary area, which suggested a salivary physiological activity. SPECT-CT of the neck and chest were then performed with a Symbia T camera. Fused images demonstrate that this activity corresponds to a cervical lymph node closely adjacent to sub-mandibulary gland. Management of the patient was then changed. In selected patients with DTC, hybrid imaging should be used as a complementary to planar imaging in terms of diagnostic accuracy, because of superior focus localization and additional anatomic information derived from the CT component. Integrated SPECT-CT is then a useful tool, especially in cases of unclear diagnoses, precising anatomical localization of areas of increased ¹³¹I-uptake and distinguishing malignant lesions from normal physiological uptakes. This is particularly important in an oncologic center, as ours, where we don’t yet have a positron emission tomography (PET) camera is not yet available.     

La Lloseta : une grotte importante et presque méconnue dans l'ensemble de Ardines, Ribadesella

This summary on The Lloseta shows us a much richer reality that it had been presented through the precedent publications. To begin it is presented as an shelter environment decorated in all their extension whose decoration and parallel they find real sense if we put them in connection with the neigh boring Tito Bustillo. It possesses a prevalence of signs and old representations, a bad general conservation and an own and original internal organization. None of the caves of Ardines, including their main protagonist, she makes isolated significant sense, but rather they are and were supplemented in the past, for activities, occupation and use. We try to know the meaning of all and each one of the caves in connection with the other ones, because we think that their function should be collective and complementary.     

Intérêt des traceurs de l’hypoxie en radiothérapie

Tumor hypoxia is a major parameter of radioresistance. Hypoxia PET imaging using several radiotracers (F-Miso, FAZA, Cu-ATSM, EF5…) may help predict response to radiotherapy. Hypoxic area evaluation may also help select patients for hypoxia-targeting drugs, and thus reinforcing radiotherapy effects. Hypoxia imaging may also be fused with radiotherapy planning CT to define radioresistance areas that may be boosted by dose-painting radiotherapy. Despite several difficulties (patient positioning, organ and tumor motion, image definition…), targeting hypoxic regions within tumors is one of the most promising research strategies of modern radiotherapy.     

Nouvelle méthode d’estimation de l’âge dentaire des Néandertaliens

Several authors have already observed the dyschronic growth between Neanderthals and modern Humans permanent teeth but they never quantified it. Dental maturation is the best and mostly used way to evaluate precisely the decease age of Neanderthals. We thus present here an extensive study realised with deciduous and immature permanent Neanderthals teeth, which lead us to propose a new mode! Of dental maturation allowing to estimate their age without using the classical modern populations dental growth tables. We propose two methods, one using two mathematical formulas, the other one using a new table, which permits to directly obtain the age of a Neanderthal from his deciduous and permanent teeth degree of maturation data.     

Témoins du froid. La faune dans l’art rupestre paléolithique de l’intérieur péninsulaire

It is our intention to analyse the environmental significance of the Palaeolithic artistic representations existing in the inner areas of the Iberian Peninsula. The fauna is used to create chronological and climatical criteria to affirm the condition of the castillan plateau during the last glaciation. In our opinion, it is dangerous to use the isolated animals in order to talk about coldness or heat situation because they reflect the cultural selection of their authors more than the ambiental reality. Neither the animals called thermometer nor the euritherm ones are solely represented in the tempered moments. Moreover, we have almost a no animal representation than artistic during the last finiglacial period in the peninsular interior. It means probably that the artistic representations are mainly cultural signs, which change for cultural reasons and not properly climatic ones within a general reality of glacial environment.     

Traitement de l’hyperthyroïdie par l’iode 131 : à propos de 280 cas

We report through this work the experience of nuclear medicine department at Ibn-Sina hospital (Rabat), in the treatment of hyperthyroidism with iodine-131. We retrospectively studied a cohort of 280 patients with hyperthyroidism, from several regions of Morocco between January 2001 and January 2010. A clinical examination and a serum assessment of TSHus, FT4 and FT3 have been made at baseline and at 3, 6, 12 and 24 months after radioiodine therapy. The activity of iodine-131 administered ranged from 296 to 740 MBq and depended on the pathology being treated, age, thyroid volume, intensity of clinical and biological hyperthyroidism and socioeconomic situation. Radioiodine therapy has often been proposed as a treatment for second or third intention, 71 patients were initially treated with iodine-131, while 209 patients had received iodine-131 after failure of medical treatment and/or recurrence after surgical treatment. Graves’ disease was the most common etiology (60%), followed by toxic adenoma (20%), and multinodular toxic goiter (13%). The therapeutic efficacy of a single dose of radioiodine evaluated after a 6-months follow-up was 92% in Graves’ disease, 98% in toxic adenomas and 97% in toxic multinodular goiter. No acute complication was observed. Taking into account our socioeconomic context, radioiodine therapy remains the preferred treatment of hyperthyroidism in our country with good value vs. price and excellent tolerance.     

Nouvelles recherches sur l’identité culturelle et stylistique de la grotte Chauvet et sur sa datation par la méthode du C

The discovery of Chauvet cave, at Vallon-Pont-d’Arc (Ardèche), in 1994, was an important event for our knowledge of palaeolithic parietal art as a whole. Its painted and engraved figures, thanks to their number (425 graphic units), and their excellent state of preservation, provide a documentary thesaurus comparable to that of the greatest sites known, and far beyond what had already been found in the group of Rhône valley caves (Ardèche and Gard). But its study – when one places it in its natural regional, cultural and thematic framework – makes it impossible to see it as an isolated entity of astonishing precocity. This needs to be reconsidered, and the affinities that our research has brought to light are clearly incompatible with the very early age which has been attributed to it. And if one extends this examination to the whole of the Franco-Cantabrian domain, the conclusion is inescapable: although Chauvet cave displays some unique characteristics (like every decorated cave), it belongs to an evolved phase of parietal art that is far removed from the motifs of its origins (known from art on blocks and on shelter walls dated by stratigraphy to the Aurignacian, in France and Cantabrian Spain). The majority of its works are therefore to be placed, quite normally, within the framework of the well-defined artistic creations of the Gravettian and Solutrean. Moreover, this phase of the Middle Upper Palaeolithic (26,000–18,000) coincides with a particularly intensive and diversified local human occupation, unknown in earlier periods and far less dense afterwards in the Magdalenian. A detailed critique of the treatment of the samples subjected to AMS radiocarbon dating makes it impossible to retain the very early age (36,000 cal BP) attributed by some authors to the painted and engraved figures of Chauvet cave.     

Le passage vers l’Atlantique : le processus de néolithisation en Algarve (sud du Portugal)

The late beginning of the research on the neolithisation in the Algarve (southern Portugal) has been providing, as a paradox, excellent conditions for the establishment of interdisciplinary research and the test of working hypotheses. The systematic projects put forward by the University of Algarve permit us today to conclude on a preliminary basis for the formation of a Neolithic enclave at ca. 5500 cal BC, centred in the coastal territories of the region. This enclave is fully Neolithic in economic terms and it is the westernmost extension of the Mediterranean Cardial. However, some specific features of these first Neolithic groups’ artefactual items (such as pottery morphology and style and some technological aspects of chipped stone production) indicate the existence of phenomena of partial reformulation of their material cultures. According to the presently available data, this complex process seems to have occurred in similar traits also in Andalucia and coastal Morocco, that is, at the moment of the passage to the Atlantic. This individualization within the Neolithic of Cardial tradition is the equivalent to the same general cultural phenomena that have been responsible for the formation, for example, of the so-called “Franco-Iberian Cardial” or “Tirrenic Cardial” at the time of settling of the Neolithic groups in these regions.     

C et style: La chronologie de l’art pariétal à l’heure actuelle

The chronology of the Paleolithic art proposed by A. Leroi-Gourhan had a strong installation among the specialists until his death, in the years 1980s of the last century. After that the system SMA of direct dating began to be applied producing some disagreements and a supposed revolution against the chronological-stylistic procedure that has been overvalued. There are not so many disagreements and when they appear, they can tinge the French author's procedure and to improve it partly. If we take it with enough flexibility and aperture, it continues being a non perfect model, but useful and valid to organize the graphs of the Upper Paleolithic whose systematic should continue based on the material documentation, in the represented forms and in all the technical procedures that allow to specify and to improve our chronological arguments.     

Les premières étapes de la colonisation de l’Europe et l’arrivée de l’Homme sur les rives de la Méditerranée

Over recent years, many discoveries have renewed our knowledge about the oldest stone industries and also about the behaviour and lifestyle of the hominids that made them, not only in East Africa, but also in the Near East, in Trans Caucasia and in southern Europe. If the first tools making hominids appear in East Africa as early as 2.55 million years ago, they are present in the Levant a little over 2 million years ago, as early as 1.81 million years ago at the gates of Europe in Trans-Caucasia, and a little over 1.4 million years ago on the Mediterranean coasts of Europe.     

Art mobilier magdalénien en matières dures animales de Moravie (République tchèque). Aspects technologique et stylistique

The Magdalenian techno-complex evolved in Western Europe and Central Europe between 17-12 kyr BP, concentrated in Spain on the Cantabrian Coast and in France in Pyrenees and Dordogne, in Central Europe in Poland and Moravia. In our study we analyse portable art on hard animal tissues from Moravian sites (Pekárna, K?í?ova, Rytí?ská), Czech Republic. Comparative material was provided by sites in South-western France (Laugerie, Basse, Enlène). The results of the technological, stylistic and typological comparisons confirm our hypothesis that the Magdalenian portable art from sites in Moravia belong to the Magdalenian techno-complex. The comparison of typological objects in Moravia, like decorated bone disc, pendants, Venus, bâton percé, spatule, shows that their variability is well in the range expected for techno-complex. The same technological pattern can be found between typological objects of spatule as a technology of decoupage but which is applied on different anatomical parts of animal raw material. We discussed the question about local origin of the objects. Technological comparison shows that engraving and bas-relief are more frequent in Moravia than in South-western France sites. This can be explained as a regional based preference of technology for expression of different subjects of mobile art, but also as a possible bias due to small sample size and differences in sampling of our studied objects. Engraving present similar technological characteristics that are featured in both areas. Design, like organization of space and size of the engraving, can be interpreted as an existence of contact between both groups and presence of one Magdalenian techno-complex.