共查询到20条相似文献,搜索用时 15 毫秒
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Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes 总被引:10,自引:0,他引:10
Miyazaki K Kawamoto T Tanimoto K Nishiyama M Honda H Kato Y 《The Journal of biological chemistry》2002,277(49):47014-47021
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Obach M Navarro-Sabaté A Caro J Kong X Duran J Gómez M Perales JC Ventura F Rosa JL Bartrons R 《The Journal of biological chemistry》2004,279(51):53562-53570
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Hypoxia-inducible factor 1 transactivates the human leptin gene promoter 总被引:15,自引:0,他引:15
Grosfeld A Andre J Hauguel-De Mouzon S Berra E Pouyssegur J Guerre-Millo M 《The Journal of biological chemistry》2002,277(45):42953-42957
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Rivera SP Wang F Saarikoski ST Taylor RT Chapman B Zhang R Hankinson O 《The Journal of biological chemistry》2007,282(15):10881-10893
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Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide 总被引:13,自引:0,他引:13
Kimura H Weisz A Ogura T Hitomi Y Kurashima Y Hashimoto K D'Acquisto F Makuuchi M Esumi H 《The Journal of biological chemistry》2001,276(3):2292-2298
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Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia 总被引:1,自引:0,他引:1
Paris S Denis H Delaive E Dieu M Dumont V Ninane N Raes M Michiels C 《FEBS letters》2005,579(1):105-114
Hypoxic environment in solid tumor is known to favor cell survival and to initiate the formation of new capillaries. In this work, we identified by 2D gel analysis 94-kDa glucose-regulated protein (GRP94) as being upregulated in human endothelial cells in response to hypoxia. Three putative hypoxia responsive elements (HRE) were found in the GRP94 promoter. Competition experiments of HIF-1 DNA binding using specific probes containing each HRE sequence of the GRP94 promoter clearly evidenced that HIF-1 binds these sequences with high affinity. The human GRP94 promoter was then cloned upstream of the luciferase gene and showed enhanced activity in hypoxic conditions. Mutation of two of the three HREs present in this promoter completely inhibited the hypoxia-induced increase in luciferase activity. 相似文献
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Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter 总被引:10,自引:0,他引:10
Coulet F Nadaud S Agrapart M Soubrier F 《The Journal of biological chemistry》2003,278(47):46230-46240
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