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Ets factors regulate the polycystic kidney disease-1 promoter 总被引:3,自引:0,他引:3
Puri S Rodova M Islam MR Magenheimer BS Maser RL Calvet JP 《Biochemical and biophysical research communications》2006,342(4):1005-1013
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K Maemura C M Hsieh M K Jain S Fukumoto M D Layne Y Liu S Kourembanas S F Yet M A Perrella M E Lee 《The Journal of biological chemistry》1999,274(44):31565-31570
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Cho JY Akbarali Y Zerbini LF Gu X Boltax J Wang Y Oettgen P Zhang DE Libermann TA 《The Journal of biological chemistry》2004,279(19):19512-19522
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The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha 总被引:3,自引:0,他引:3
Hepatitis B virus X protein (HBx) of the hepatitis B virus is strongly implicated in angiogenesis and metastasis during hepatocarcinogenesis. Previously, we reported that HBx enhances activity of hypoxia-inducible factor-1alpha (HIF-1alpha), a potent transactivator that induces angiogenic factors. Here, we delineate the structural region of HBx that potentiates HIF-1alpha. The carboxy-terminus of HBx increased the stability of HIF-1alpha protein, probably through inhibiting interaction with von Hippel-Lindau protein. Further, the carboxy-terminus of HBx enhanced the transactivation function of HIF-1alpha by enhancing its association with CREB binding protein (CBP). Finally, we demonstrated the physical association of HBx with the basic helix-loop-helix/PER-ARNT-SIM domain, the inhibitory domain, and the carboxy-terminal transactivation domain of HIF-1alpha in vivo. 相似文献