Systemic candidiasis with meningeal involvement in a newborn infant

The newborn with sepsis (E. coli) and salmonellosis was described. After treatment with broad-spectrum antibiotics it was suffered from Candida albicans (Meningitis with Hydrocephalus internus, Chorioretinitis and Ostitis). The authors difficulties connected with diagnosis and anti-fungal therapy have showed. They have punctated the necessity of combined anti-mycotic therapy.     

Reye's syndrome in a newborn infant

A case of Reye''s syndrome in a newborn infant, believed to be the first recorded in the perinatal period, is reported. The clinical, biochemical and histological findings are those previously recognized in older infants. The intractable acidosis, hypoglycemia and extreme degree of lactic acidosis reflect an advanced degree of hepatic involvement, probably initiated in utero, with resultant impairment of glycogenolysis and intermediary metabolism.     

Full trisomy 22 in a newborn infant

Karyotype 47,XY,+22 was found in a newborn infant with primitive and low-set ears, bilateral preauricular pit, broad nasal bridge, antimongoloid palpebral fissures, macroglossia, enlarged sublingual glands, cleft palate, micrognathia, clinodactyly of the fifth fingers, hypoplastic finger nails, hypoplastic genitalia, short lower limbs, bilateral sandal gap and deep plantar furrows. The child developed signs of congenital heart disease and died at the age of 10 weeks. Non-disjunction studies showed maternal origin (meiosis I) of the extrachromosome.     

Mechanical human heart work in a newborn infant

The echo- and dopplerography of newborn infants up to 10-day age revealed that their heart work capacity was about 6 Wt, relative capacity--25 Wt/100 g of ventricular mass. These data correspond to those of adult humans. The Frank-Starling mechanism was corroborated.     

血液分离的肺炎克雷伯菌的患者疾病类型及耐药谱分析

目的 调查血液分离的肺炎克雷伯菌的耐药谱.方法 收集温州医学院附属第一医院2005年1月至2009年9月间血液分离的肺炎克雷伯菌,采用全自动微生物分析仪对肺炎克雷伯菌进行菌种鉴定和药敏试验,超广谱β-内酰胺酶的检测采用仪器法.舒普深和美洛培南的药敏试验采用K-B法.结果 80株分离自血液的肺炎克雷伯菌主要分离自患有肝胆疾病、血液系统疾病、呼吸系统疾病和神经系统疾病的患者,分别占20.0％、17.5％ 、15.0％和13.7％.80株肺炎克雷伯菌中,10株ESBLs阳性,阳性率为12.5％(10/80).除肺炎克雷伯菌对氨苄西林100％耐药外,对其他15种被测抗菌药物的耐药率全部低于20％,所有被测菌株对亚胺培南和美洛培南全部敏感,对其他9种抗菌药物的耐药率也低于10％.结论 血液分离的肺炎克雷伯菌主要来自患有肝胆疾病、血液系统疾病和神经系统疾病的患者.血液分离的肺炎克雷伯菌的ESBLs检出率非常低,且对常用抗菌药物的耐药率非常低.     

A novel WT1 gene mutation in a newborn infant diagnosed with Denys-Drash syndrome

Denys-Drash syndrome (DDS) is a rare disorder characterized by glomerulopathy, genital abnormalities and predisposition to Wilms' tumor. It is associated with constitutional Wilms'tumor suppressor 1 (WT1) gene mutations, in which the majority being missense mutations in the zinc-finger region. Here, we present a newborn with DDS, associated with a novel heterozygous missense mutation, p.Asp396His, on exon 9 of WT1.