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Nicole Schreiber-Agus Ronald A. DePinho 《BioEssays : news and reviews in molecular, cellular and developmental biology》1998,20(10):808-818
The functions of Myc in transformation and transactivation are countered by the suppressive actions of the Mad(Mxi1) family. Mad(Mxi1) proteins not only compete with Myc for dimerization to Max and binding to Myc/ Max consensus sites but also recruit powerful repressors of gene expression. A prediction of the yin-yang relationship between Myc and Mad(Mxi1) families would be that the latter constitutes a new class of tumor suppressors. Here, we review the current literature on the Mad(Mxi1) family, with particular attention paid to the molecular mechanisms by which these proteins antagonize the actions of Myc in normal and neoplastic cells. BioEssays 20 :808–818, 1998. © 1998 John Wiley & Sons, Inc. 相似文献
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The Mad and Myc basic domains are functionally equivalent 总被引:4,自引:0,他引:4
Nikiforov MA Popov N Kotenko I Henriksson M Cole MD 《The Journal of biological chemistry》2003,278(13):11094-11099
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Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro 总被引:7,自引:0,他引:7 下载免费PDF全文
《The Journal of cell biology》1995,128(6):1197-1208
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