共查询到20条相似文献,搜索用时 921 毫秒
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Ishiko E Matsumura I Ezoe S Gale K Ishiko J Satoh Y Tanaka H Shibayama H Mizuki M Era T Enver T Kanakura Y 《The Journal of biological chemistry》2005,280(6):4929-4939
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Rodriguez P Bonte E Krijgsveld J Kolodziej KE Guyot B Heck AJ Vyas P de Boer E Grosveld F Strouboulis J 《The EMBO journal》2005,24(13):2354-2366
GATA-1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and mast cell lineages. It acts as an activator and repressor of different target genes, for example, in erythroid cells it represses cell proliferation and early hematopoietic genes while activating erythroid genes, yet it is not clear how both of these functions are mediated. Using a biotinylation tagging/proteomics approach in erythroid cells, we describe distinct GATA-1 interactions with the essential hematopoietic factor Gfi-1b, the repressive MeCP1 complex and the chromatin remodeling ACF/WCRF complex, in addition to the known GATA-1/FOG-1 and GATA-1/TAL-1 complexes. Importantly, we show that FOG-1 mediates GATA-1 interactions with the MeCP1 complex, thus providing an explanation for the overlapping functions of these two factors in erythropoiesis. We also show that subsets of GATA-1 gene targets are bound in vivo by distinct complexes, thus linking specific GATA-1 partners to distinct aspects of its functions. Based on these findings, we suggest a model for the different roles of GATA-1 in erythroid differentiation. 相似文献
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FOG acts as a repressor of red blood cell development in Xenopus 总被引:4,自引:0,他引:4
Deconinck AE Mead PE Tevosian SG Crispino JD Katz SG Zon LI Orkin SH 《Development (Cambridge, England)》2000,127(10):2031-2040
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Shimizu R Kuroha T Ohneda O Pan X Ohneda K Takahashi S Philipsen S Yamamoto M 《Molecular and cellular biology》2004,24(24):10814-10825
GATA-1 is essential for the development of erythroid and megakaryocytic lineages. We found that GATA-1 gene knockdown female (GATA-1.05/X) mice frequently develop a hematopoietic disorder resembling myelodysplastic syndrome that is characterized by the accumulation of progenitors expressing low levels of GATA-1. In this study, we demonstrate that GATA-1.05/X mice suffer from two distinct types of acute leukemia, an early-onset c-Kit-positive nonlymphoid leukemia and a late-onset B-lymphocytic leukemia. Since GATA-1 is an X chromosome gene, two types of hematopoietic cells reside within heterozygous GATA-1 knockdown mice, bearing either an active wild-type GATA-1 allele or an active mutant GATA-1.05 allele. In the hematopoietic progenitors with the latter allele, low-level GATA-1 expression is sufficient to support survival and proliferation but not differentiation, leading to the accumulation of progenitors that are easily targeted by oncogenic stimuli. Since such leukemia has not been observed in GATA-1-null/X mutant mice, we conclude that the residual GATA-1 activity in the knockdown mice contributes to the development of the malignancy. This de novo model recapitulates the acute crisis found in preleukemic conditions in humans. 相似文献
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Peng-Fei Zhai Fang Wang Rui Su Hai-Shuang Lin Chong-Liang Jiang Gui-Hua Yang Jia Yu Jun-Wu Zhang 《The Journal of biological chemistry》2014,289(33):22600-22613
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Immortalization of multipotent growth-factor dependent hemopoietic progenitors from mice transgenic for GATA-1 driven SV40 tsA58 gene. 总被引:2,自引:0,他引:2 下载免费PDF全文
L A Cairns S Crotta M Minuzzo E Moroni F Granucci S Nicolis R Schiró L Pozzi B Giglioni P Ricciardi-Castagnoli et al. 《The EMBO journal》1994,13(19):4577-4586