共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
4.
5.
6.
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion 总被引:10,自引:0,他引:10 下载免费PDF全文
Yang HS Matthews CP Clair T Wang Q Baker AR Li CC Tan TH Colburn NH 《Molecular and cellular biology》2006,26(4):1297-1306
7.
8.
9.
10.
11.
12.
13.
14.
Dohi K Mizushima H Nakajo S Ohtaki H Matsunaga S Aruga T Shioda S 《Regulatory peptides》2002,109(1-3):83-88
We have demonstrated that ischemic neuronal death (apoptosis) of rat CA1 region of the hippocampus was prevented by infusing pituitary adenylate cyclase-activating polypeptide (PACAP) either intracerebroventricularly or intravenously. We have also demonstrated that the activity of mitogen-activated protein (MAP) kinase family members, including ERK (extracellular signal-regulated kinase), Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and p38, was increased in the hippocampus within 1-6 h after brain ischemia. The molecular mechanisms underlying the PACAP anti-apoptotic effect were demonstrated in this study. Ischemic stress had a strong influence on MAP kinase family, especially on JNK/SAPK and p38. PACAP inhibited the activation of JNK/SAPK and p38 after ischemic stress, while ERK is not suppressed. These findings suggest that PACAP inhibits the JNK/SAPK and p38 signaling pathways, thereby protecting neurons against apoptosis. 相似文献
15.
16.
17.
18.
19.
Laderoute KR Mendonca HL Calaoagan JM Knapp AM Giaccia AJ Stork PJ 《The Journal of biological chemistry》1999,274(18):12890-12897