共查询到20条相似文献,搜索用时 15 毫秒
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Gisbert JP Calvet X Feu F Bory F Cosme A Almela P Santolaria S Aznárez R Castro M Fernández N García-Grávalos R Cañete N Benages A Montoro M Borda F Pérez-Aisa A Piqué JM 《Helicobacter》2007,12(4):279-286
AIM: To evaluate the effect of Helicobacter pylori eradication on ulcer bleeding recurrence in a prospective, long-term study including more than 400 patients. METHODS: Patients with peptic ulcer bleeding were prospectively included. H. pylori infection was confirmed by rapid urease test, histology or (13)C-urea breath test. Several eradication regimens were used. Ranitidine 150 mg was administered daily until eradication was confirmed by breath test 8 weeks after completing eradication therapy. Patients with therapy failure received a second or third course of therapy. Patients with eradication success did not receive maintenance anti-ulcer therapy, and were controlled yearly with a repeated breath test. RESULTS: Four hundred and twenty-two patients were followed up for at least 12 months, with a total of 906 patient-years of follow up. Mean age was 59 years, and 35% were previous nonsteroidal anti-inflammatory drug (NSAID) users. Sixty-nine percent had duodenal, 24% gastric, and 7% pyloric ulcer. Recurrence of bleeding was demonstrated in two patients at 1 year (incidence: 0.22% per patient-year of follow up), which occurred after NSAID use in both cases. CONCLUSION: Peptic ulcer rebleeding does not occur in patients with complicated ulcers after H. pylori eradication. Maintenance anti-ulcer (antisecretory) therapy is not necessary if eradication is achieved. 相似文献
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J Chojnacki G Klupińska S Badylak J Jackowicz S Jab?oński 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1989,44(49-52):960-961
Cimetidine in the daily dose of 1,000 mg was administered orally to menopausal women (group I) with peptic ulcer. The group II (n = 25) was given cimetidine (1,000 mg/24 hours) with stilboestrol in the daily dose of 1 mg. Healing of the ulcers was seen in 16 women of group I (72.7%) and in 23 women of group II (92.0%; p less than 0.05) following a 6-week treatment. 相似文献
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S J Konturek 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1971,26(46):1765-1768
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Sister Joseph 《BMJ (Clinical research ed.)》1985,291(6509):1648-1649
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