共查询到20条相似文献,搜索用时 15 毫秒
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Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification 总被引:1,自引:0,他引:1
Hong Y Rogers R Matunis MJ Mayhew CN Goodson ML Park-Sarge OK Sarge KD Goodson M 《The Journal of biological chemistry》2001,276(43):40263-40267
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Conde R Xavier J McLoughlin C Chinkers M Ovsenek N 《The Journal of biological chemistry》2005,280(32):28989-28996
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Inhibition of heat shock transcription factor by GR. 总被引:8,自引:0,他引:8
S A Wadekar D Li S Periyasamy E R Sánchez 《Molecular endocrinology (Baltimore, Md.)》2001,15(8):1396-1410
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Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. 总被引:11,自引:0,他引:11 下载免费PDF全文
Carina I. Holmberg Ville Hietakangas Andrey Mikhailov Jouni O. Rantanen Marko Kallio Annika Meinander Jukka Hellman Nick Morrice Carol MacKintosh Richard I. Morimoto John E. Eriksson Lea Sistonen 《The EMBO journal》2001,20(14):3800-3810
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Geldanamycin restores a defective heat shock response in vivo 总被引:5,自引:0,他引:5
Winklhofer KF Reintjes A Hoener MC Voellmy R Tatzelt J 《The Journal of biological chemistry》2001,276(48):45160-45167
Induced expression of heat shock proteins (Hsps) plays a central role in promoting cellular survival after environmental and physiological stress. We have previously shown that scrapie-infected mouse neuroblastoma (ScN2a) cells fail to induce the expression of Hsp72 and Hsp28 after various stress conditions. Here we present evidence that this impaired stress response is due to an altered regulation of HSF1 activity. Upon stress in ScN2a cells, HSF1 was converted into hyperphosphorylated trimers but failed to acquire transactivation competence. A kinetic analysis of HSF1 activation revealed that in ScN2a cells trimer formation after stress was efficient, but disassembly of trimers proceeded much faster than in the uninfected cell line. Geldanamycin, a Hsp90-binding drug, significantly delayed disassembly of HSF1 trimers after a heat shock and restored stress-induced expression of Hsp72 in ScN2a cells. Heat-induced Hsp72 expression required geldanamycin to be present; following removal of the drug ScN2a cells again lost their ability to mount a stress response. Thus, our studies show that a defective stress response can be pharmacologically restored and suggest that the HSF1 deactivation pathway may play an important role in the regulation of Hsp expression. 相似文献
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Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures 下载免费PDF全文
Inouye S Katsuki K Izu H Fujimoto M Sugahara K Yamada S Shinkai Y Oka Y Katoh Y Nakai A 《Molecular and cellular biology》2003,23(16):5882-5895
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