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Metazoans establish with microorganisms complex interactions for their mutual benefits. Drosophila, which has already proven useful host model to study several aspects of innate immunity and host-bacteria pathogenic associations has become a powerful model to dissect the mechanisms behind mutualistic host-microbe interactions. Drosophila microbiota is composed of simple and aerotolerant bacterial communities mostly composed of Lactobacillaceae and Acetobactereaceae. Drosophila mono- or poly-associated with lactobacilli strains constitutes a powerful model to dissect the complex interplay between lactobacilli and host biologic traits. Thanks to the genetic tractability of both Drosophila and lactobacilli this association model offers a great opportunity to reveal the underlying molecular mechanisms. Here, we review our current knowledge about how the Drosophila model is helping our understanding of how lactobacilli shapes host biology. 相似文献
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Background
In the last few years stud farms have experienced increasing problems with Parascaris equorum infections in foals despite intensive deworming programs. This has led to the question as to whether the anthelmintic drugs used against this parasite are failing. This study aimed to investigate the efficacy of ivermectin, fenbendazole and pyrantel on the faecal output of ascarid eggs of foals. 相似文献9.
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Naftale Katz Flávia Fernanda Bubulo Couto Neusa Araújo 《Memórias do Instituto Oswaldo Cruz》2013,108(7):850-853
Imatinib, a drug used for treatment of human chronic myeloid leukaemia, due to
its activity against protein kinases, has been also evaluated in vitro against
Schistosoma mansoni showing high schistosomicidal activity.
In the present experiments imatinib activity in vitro was confirmed at the doses
of 25 µM, 50 µM and 100 µM. The first drug activity observed with the lower dose
was interruption of egg-laying and with the higher dosages was the death of the
worms. In mice infected with S. mansoni no activity was found
even with 1,000 mg/kg/day, 500 mg/kg/day, single oral dose or when administered
for three consecutive days. This is another example of the difference of results
related to in vitro and in vivo trials using S. mansoni
worms. 相似文献
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