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1.
Ersoy IH Koroglu BK Varol S Ersoy S Varol E Aylak F Tamer MN 《Biological trace element research》2011,143(2):619-624
Although there are many studies on effect of fluoride on trace elements in experimental animals, few studies exist on serum
trace elements levels in patients with endemic fluorosis. We aimed to determine the serum levels of trace elements including
serum copper (Cu), zinc (Zn), and serum levels of minerals including calcium (Ca), phosphorus (P), magnesium (Mg), sodium
(Na), potassium (K) in patients with endemic fluorosis. The study group consisted of 30 patients with endemic fluorosis (17
females, 13 males, mean age 33.53 ± 9.85 years). An age, gender, and body mass index matched 30 healthy volunteers comprised
control group (21 females, ten males with a mean age 33.93 ± 7.39 years). Urine fluoride levels of chronic fluorosis patients
were significantly higher than that of control subjects as expected (1.92 ± 0.10 mg/l vs. 0.41 ± 0.09 mg/l, respectively;
P < 0.001). Serum Cu levels (89.14 ± 16.77 μg/dL vs. 102.69 ± 25.04 μg/dL, respectively, P = 0.017), serum Zn levels (77.98 ± 20.58 μg/dL vs. 94.57 ± 35.87μg/dL, respectively, P = 0.032), and serum Mg levels (1.92 ± 0.18 mg/dL vs. 2.07 ± 0.31 mg/dL, respectively, p = 0.022) was significantly lower in chronic fluorosis patients than in controls. There were no statistically significant
differences between the fluorosis group and control group with respect to serum levels of Na, K, Ca, and P. We concluded that
chronic fluorosis is associated with reduced serum levels of Cu, Zn, and Mg. 相似文献
2.
Weisstaub G Hertrampf E López de Romaña D Salazar G Bugueño C Castillo-Duran C 《Biological trace element research》2007,118(2):167-174
Zinc (Zn) deficiency and obesity can be observed together in some developing countries. Zn deficiency may enhance fat deposition
and decrease lean mass accrual, which in turn, appears to influence physical activity (PA), although this has not yet been
evaluated in obese children. The objective of the study was to find out the association between measurements of plasma Zn
and serum leptin, body composition, and PA in Chilean obese preschool children. Seventy-two 18- to 36-month-old obese children
[weight-for-length/height z score (WHZ) > 2.0 SD], belonging to low socioeconomic communities, participated in the study. Plasma Zn, serum leptin, weight,
waist circumference, height, total body water (TBW) assessed by deuterium isotopic dilution technique and daily activity,
measured by registering 48 h with an accelerometer, were evaluated. We found 82% of children with WHZ > 3 SD. The geometric
mean Zn intake was 6.2 ± 2.5 mg/day. The mean plasma Zn was 91.8 ± 11.4 μg/dL, with 10% of the children having levels <80 μg/dL.
No correlation was found between plasma Zn concentrations and either weight, WHZ, or waist circumference. Serum leptin was
lower in males than in females (2.9 ± 2.8 vs 6.8 ± 5.0 ng/mL, respectively; p < 0.001). TBW was different between males and females (56.2 ± 5.4 vs 52.8 ± 4.3% body weight, respectively; p = 0.004), but no significant association was found between TBW and plasma Zn. Moderate + intense PA, (as percentage of wake
time), was greater in males than in females (6.3 ± 3.1% vs 3.4 ± 2.3%, respectively; p < 0.001), but it was not significantly correlated to plasma Zn. In conclusion, plasma Zn was not associated with body composition
as assessed by TBW, serum leptin, or with the magnitude of physical activity in Chilean overweight preschool children. 相似文献
3.
Tohidi M Ghasemi A Hadaegh F Arbabi S Hosseini Isfahani F 《Biological trace element research》2011,143(2):835-843
This study aims at determining the association between markers of hepatic injury and serum, urinary, and intra-erythrocyte
magnesium concentrations and dietary magnesium intake in obese children and adolescents. In a case–control study, 42 obese
children and adolescents (8–18 years) and 42 sex- and puberty-matched controls were studied. Serum, urinary, and intra-erythrocyte
magnesium levels, indices of insulin sensitivity, and liver enzymes were measured. Dietary magnesium intake was assessed using
a food frequency questionnaire. Obese children and adolescents exhibited insulin resistance as determined by a higher fasting
insulin and the HOMA-IR (p < 0.001) and lower QUICKI indices (p = 0.001); in addition these subjects had significantly higher intra-erythrocyte magnesium (IEM) concentrations, than non-obese
ones (3.99 ± 1.05 vs. 3.35 ± 1.26 mg/dL of packed cell; p = 0.015). Among liver enzymes, only gamma-glutamyl transferase (GGT) was significantly higher in obese than in non-obese
subjects (22.7 ± 9.4 vs. 17.1 ± 7.9 U/l; p = 0.002). A positive association was found between GGT and IEM in both groups; however in multivariate analysis, in obese
subjects, only GGT (p = 0.026) and, in non-obese subjects, only age (p = 0.006) remained as significant predictors of IEM. In conclusion, increased IEM concentration was seen in insulin-resistant
obese children and adolescents; furthermore, serum GGT was associated with IEM, independently of body mass index and HOMA-IR. 相似文献
4.
Young-Jae Kim Oyunbileg Galindev Jun Han Sei Su-Mi Bae Hosub Im Lanying Wen Young Rok Seo Woong Shick Ahn 《Biological trace element research》2009,131(2):103-109
Of trace elements in the serum of living organisms, selenium (Se) is an essential mineral and plays the role of an antioxidant
as selenoproteins protecting the organism against oxidative damage induced by hydrogen peroxide, other lipid hydroperoxides,
and their derivatives. The aim of this study was to determine the mean serum Se levels in healthy Korean volunteers (50 males
and 50 females) by using an inductively coupled plasma-mass spectrometry method. The samples were collected at the Health
Promotion Centre of Kangnam St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, Kangnam District,
Seoul in accordance with procedures approved by the Institutional Review Board of the Catholic University of Korea. The mean
serum Se level in healthy subjects was 112.05 ± 30.42 μg/l. For gender, it was 120.81 ± 27.37 μg/l for females and 103.29 ± 31.05 μg/l
for males. From the study result, there was a significant difference between the mean Se concentrations of gender groups (p = 0.0035). Also, the study indicated no effect of age on Se levels (p > 0.05) in the healthy individuals. 相似文献
5.
The serum concentrations of copper, zinc, iron, and cobalt and copper/zinc ratio were investigated in horses infected with
equine herpesvirus-1 (EHV-1). Nine horses were naturally infected with the virus and nine healthy horses served as controls.
The concentrations of copper, zinc, iron, and cobalt were determined spectrophotometrically in the blood serum of all horses.
The results were (expressed in micrograms per deciliters) copper 2.80 ± 0.34 vs 1.12 ± 0.44, zinc 3.05 ± 0.18 vs 0.83 ± 0.06,
iron 2.76 ± 0.17 vs 3.71 ± 0.69, cobalt 0.19 ± 0.37 vs 0.22 ± 0.45, and copper/zinc ratio 0.72 ± 0.38 vs 1.41 ± 0.36 for control
vs infected group, respectively. In conclusion, copper and zinc concentrations of the infected group were lower than the control
group (p < 0.001), whereas iron concentration and the copper/zinc ratio of the infected group were higher than the control group (p < 0.05 and p < 0.001). The cobalt concentration was not found to be statistically different between two groups. It might be emphasized
that copper/zinc ratio was significantly affected by the EHV-1 infection, so it could be taken into consideration during the
course of infection.
An erratum to this article can be found at 相似文献
6.
Abakay A Gokalp O Abakay O Evliyaoglu O Sezgi C Palanci Y Ekici F Karakus A Tanrikulu AC Ayhan M 《Biological trace element research》2012,145(2):151-157
The aim of this study was to investigate the respiratory function disorders that could be related to dust exposure during
the production of copper mine in copper mineworkers (CMWs). The study included 75 male CMWs (mean age, 32.0 ± 7.1 years, 58.6%
smokers) and 75 male age- and smoking status-matched healthy control subjects. Serum Cu level was significantly higher in
the CMW group (0.80 ± 0.62 μg/ml) than the control group (0.60 ± 0.39 μg/ml) (p = 0.017). Significant negative correlations were found between serum Cu level and forced expiratory volume in first second
(r = −0.600; p < 0.001) and between serum Cu level and forced vital capacity (r = −0.593; p = <0.001) in CMWs. Serum Cu level was significantly higher in the restrictive type pulmonary function disorders group (1.36 ± 0.62 μg/ml)
than obstructive type (0.90 ± 0.55 μg/ml) and normal pulmonary function pattern group (0.53 ± 0.43 μg/ml) (p < 0.001). Patients with radiological parenchymal abnormalities had significantly higher serum copper levels than those without
abnormalities (1.53 ± 0.52 vs. 0.71 ± 0.52 μg/ml, respectively; p = 0.002). In conclusion, result of the study has shown a negative association between pulmonary functions disorders and radiological
abnormalities and serum Cu levels in CMWs. 相似文献
7.
Ferro FE de Sousa Lima VB Soares NR de Sousa Almondes KG Pires LV Cozzolino SM do Nascimento Marreiro D 《Biological trace element research》2011,143(2):787-793
Alterations in antioxidant defense in obese people with metabolic syndrome can contribute to oxidative stress. This study
assessed the relationship between the parameters of metabolic syndrome and the zincemia, activity of superoxide dismutase,
and glutathione peroxidase enzymes in obese women. Seventy-three premenopausal women, aged between 20 and 50 years, were divided
into two groups: case group, composed of obese (n = 37), and control group, composed of no obese (n = 36). Analyses of zinc intake, parameters of metabolic syndrome, plasma, and erythrocyte zinc, and activities of superoxide
dismutase and glutathione peroxidase were carried out. The mean values of body mass index of obese women and control group
were 34.5 ± 3.4 and 21.7 ± 1.9 kg/m2, respectively (p < 0.05). In the study, body mass index, waist circumference, and zinc intake were higher in obese women than control group
(p < 0.05). The plasma zinc and activity of superoxide dismutase did not show significant differences between obese and controls
(p > 0.05). The values of erythrocyte zinc was 36.4 ± 15.0 μg/gHb and 45.4 ± 14.3 μg/gHb and of glutathione peroxidase was 46.4 ± 19.4 U/gHb
and 36.7 ± 13.6 U/gHb in obese women and controls, respectively (p < 0.05). The study shows that there are alterations in biochemical parameters of zinc in obese women, with low zinc concentrations
in erythrocytes. Regression analysis demonstrates that the erythrocyte zinc and activity of superoxide dismutase enzyme is
influenced by components of the metabolic syndrome, and the plasmatic glucose, body mass index, and waist circumference have
a negative correlation with this enzyme. 相似文献
8.
The sialic acid/glycosaminoglycan ratio was determined in 35 coronary artery ectasia patients and 35 control subjects to determine
the possible role of fluoride in the etiology of the disease. The coronary artery ectasia patients and controls were selected
from subjects who underwent coronary angiography. The mean serum sialic acid level was significantly lower in patients with
coronary artery ectasia (CAE) than in controls (340.3 ± 28.6 vs. 427.0 ± 15.9 μg/mL, respectively; p < 0.001). The mean serum glycosaminoglycan level was significantly higher in patients with CAE than in controls (5,013.1 ± 158.6
vs. 3,833.6 ± 237.1 μg/mL, respectively; p < 0.001). The sialic acid/glycosaminoglycan ratio in patients with coronary artery ectasia was significantly lower than in
controls (0.068 ± 0.007 vs. 0.111 ± 0.005; p < 0.001). There was more than 38.7% reduction in this ratio in patients with CAE when compared with controls. We demonstrated
that chronic fluoride exposure has an important role in pathogenesis of coronary artery ectasia. 相似文献
9.
Deficiencies in Cu, Se, and Zn impair one or more biochemical functions, and excess are associated with toxicity. Baseline
studies on the Ghanaian population are scanty. The study was undertaken to determine whether significant rural/urban differences
in the serum levels of Cu, Se, and Zn did exist. Forty males/60 females from rural and 50 males/50 females from urban Ghanaian
communities were sampled. Serum Cu, Se, and Zn were determined using flame atomic absorption spectrometry. Cu level for rural
and urban subjects was 997 ± 333 and 979 ± 290 μg/L, respectively (p = 0.68). However, Cu levels were significantly higher in the rural females (1,063 ± 367 μg/L) than the rural males (898 ± 249 μg/L;
p = 0.0085). Se levels for rural/urban subjects were 97 ± 36 and 87 ± 31 μg/L, respectively (p = 0.03). Zn levels in the rural/urban subjects were 312 ± 218 and 150 ± 102 μg/L, respectively (p = 0.002). Additionally, Zn was significantly higher in rural females (428 ± 204 μg/L) than the urban females (166 ± 103 μg/L;
p = 0.0002). Finally, Zn was significantly higher in rural females (428 ± 204 μg/L) than males (172 ± 116 μg/L; p = 0.0028). In conclusion, Cu, Se, and Zn were higher in the rural group compared to the urban group, and the generally low
Zn levels were confirmed in another cohort follow-up study. 相似文献
10.
Ozkaya M Sahin M Cakal E Gisi K Bilge F Kilinc M 《Biological trace element research》2009,128(2):144-151
The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR)
according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied
in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 ± 5.9 vs 88.7 ± 8.7 μg/dl,
p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 ± 0.9
vs 0.63 ± 0.4 mg/dL, p < 0.0001; 2.07 ± 0.84 vs 1.51 ± 0.69, p < 0.0001; 9.26 ± 3.8 vs 6.8 ± 2.98 μU/MI, p < 0.0001; 15.7 ± 7.4 vs 11.5 ± 5.1 μmol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = − 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = −0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine
levels in individuals with selenium levels < 80 μg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels ≥ 80 (n = 91; 1.23 ± 0.98 vs 0.81 ± 0.76 mg/dL, p < 0.003; 1.99 ± 0.88 vs 1.64 ± 0.74, p < 0.005; 15.0 ± 7.6 vs 12.9 ± 5.7 μmol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR. 相似文献
11.
Rahman A Azad MA Hossain I Qusar MM Bari W Begum F Huq SM Hasnat A 《Biological trace element research》2009,127(2):102-108
The purpose of the study was to determine the concentration of trace elements present in scalp hair sample of schizophrenic
patients and to find out the relationship between trace elements level and nutritional status or socioeconomic factors. The
study was conducted among 30 schizophrenic male patients and 30 healthy male volunteers. Patients were recruited from Bangabandhu
Sheikh Mujib Medical University by random sampling. Hair trace element concentrations were determined by flame atomic absorption
spectroscopy and analyzed by independent t test, Pearson’s correlation analysis, regression analysis, and analysis of variance (ANOVA). Mn, Zn, Ca, Cu, and Cd concentrations
of schizophrenic patients were 3.8 ± 2.31 μg/gm, 171.6 ± 59.04 μg/gm, 396.23 ± 157.83 μg/gm, 15.40 ± 5.68 μg/gm, and 1.14 ± 0.89 μg/gm
of hair sample, while those of control subjects were 4.4 ± 2.32 μg/gm, 199.16 ± 27.85 μg/gm, 620.9 ± 181.55 μg/gm, 12.23 ± 4.56 μg/gm,
and 0.47 ± 0.32 μg/gm of hair sample, respectively. The hair concentration of Zn and Ca decreased significantly (p = 0.024; p = 0.000, respectively) and the concentration of Cu and Cd increased significantly (p = 0.021; p = 0.000, respectively) in schizophrenic patients while the concentration of Mn (p = 0.321) remain unchanged. Socioeconomic data reveals that most of the patients were poor, middle-aged and divorced. Mean
body mass indices (BMIs) of the control group (22.26 ± 1.91 kg/m2) and the patient group (20.42 ± 3.16 kg/m2) were within the normal range (18.5−25.0 kg/m2). Pearson’s correlation analysis suggested that only Ca concentration of patients had a significant positive correlation
with the BMI (r = 0.597; p = 0.000) which was further justified from the regression analysis (R
2 = 44%; t = 3.59; p = 0.002) and one-way ANOVA test (F = 3.62; p = 0.015). A significant decrease in the hair concentration of Zn and Ca as well as a significant increase in the hair concentration
of Cu and Cd in schizophrenic patients than that of its control group was observed which may provide prognostic tool for the
diagnosis and treatment of this disease. However, further work with larger population is suggested to examine the exact correlation
between trace element level and the degree of disorder. 相似文献
12.
The relationship between plasma levels of homocysteine (Hcy) and femur bone mineral density (BMD) was studied in Wistar rats.
After 8 weeks of treatment with 0.5 and 1.0 g kg−1 day−1
l-methionine the mean plasma levels of Hcy were 7.67 ± 1.25 and 61.2 ± 11.4 μmol/l, respectively. Only rats treated with the
higher dose had Hcy levels significantly higher than those of controls, 6.38 ± 0.90 μmol/l (p < 0.001). Dual Energy X-ray Absorptiometry was used to measure the BMD, which was significantly lower only in the animals
with the highest plasma levels of Hcy (p < 0.001). This led us to conclude that increased levels of Hcy are associated with risk of decreased BMD. 相似文献
13.
Mohammad Abbasi Nazari Farzad Kobarfard Payam Tabarsi Jamshid Salamzadeh 《Biological trace element research》2009,128(2):161-166
Ethambutol is an oral anti-tuberculosis agent with chelating effects owing to its chemical structure which is similar to that
of penicillamine. Copper (Cu) is an essential trace element that has important roles in physiological function of the body
organs. The aim of present study was to determine (1) whether ethambutol usage can alter serum Cu concentration in patients
with tuberculosis and (2) whether there is any relationship between age, sex, and smoking habit of patients with changes in
serum Cu levels. Sixty patients with diagnosis of pulmonary tuberculosis were enrolled the study. Blood samples were obtained
before treatment (baseline) and 10 days after starting anti-tuberculosis therapy. The amounts of serum Cu were determined
in all samples by atomic absorption. Mean ± SD levels of Cu at baseline and on the 10th day of ethambutol use were 0.94 ± 0.24
and 0.64 ± 0.24 μg/mL, respectively. Statistical analysis confirmed a significant difference (p < 0.0001). Also, there was not any relationship between changes in Cu concentration and study variables of age, sex, and
smoking habit. Our findings endorse the chelating effect of ethambutol leading to a decrease in serum levels of cationic trace
elements, e.g., Cu. 相似文献
14.
Monica Daniela Doşa Laurentiu-Tony Hangan Eduard Crauciuc Cristina Galeş Mihai Nechifor 《Biological trace element research》2011,142(1):36-46
Research was performed on a group of 30 patients with non-insulin-dependent diabetes mellitus (NIDDM), who never received
antidiabetic medication before, and on a group of 17 healthy adults. The patients were administered treatment with metformin,
1,000 mg/day. Plasmatic and urinary concentration of magnesium have been measured, copper and zinc along with the concentrations
of glucose, HDL, LDL, cholesterol, tryglicerides, HbA1c, and total erythrocyte magnesium, in advance and after 3 months of
treatment. Data showed significant differences in the NIDDM group vs the control group: for plasma magnesium—1.95 ± 0.19 vs
2.20 ± 0.18 mg/dl, p < 0.001; urine magnesium—237.28 ± 34.51 vs 126.25 ± 38.22 mg/24 h, p < 0.001; erythrocyte magnesium—5.09 ± 0.63 vs 6.38 ± 0.75 mg/dl, p < 0.001; plasma zinc—67.56 ± 6.21 vs 98.41 ± 20.47 μg/dl, p < 0.001; urine zinc—1,347.54 ± 158.24 vs 851.65 ± 209.75 μg/24 h, p < 0.001; plasma copper—111.91 ± 20.98 vs 96.33 ± 8.56 μg/dl, p < 0.001; and urine copper—51.70 ± 23.79 vs 36.00 ± 11.70 μg/24 h, p < 0.05. Treatment with metformin for 3 months modified significant erythrocyte magnesium—5.75 ± 0.61 vs 5.09 ± 0.63 mg/dl,
p < 0.001 and urine magnesium—198.27 ± 27.07 vs 237.28 ± 34.51 mg/24 h, p < 0.001, whereas it did not modify significant the plasmatic and urinary concentration of the other cations. The erythrocyte
magnesium concentration was inversely correlated with HbA1c (r = −0.438, p = 0.015). The plasma level of copper was positively correlated with HbA1c (r = 0.517, p < 0.003), tryglicerides (r = 0.534, p < 0.003), and cholesterol (r = 0.440, p < 0.05), and the plasma level of zinc was inversely correlated with glycemia (r = −0.399, p = 0.029). Our data show a significant action of metformin therapy, by increasing the total intraerythrocyte magnesium concentration
and decreasing the urinary magnesium elimination, positively correlated with the decrease of glycemia and HbA1c in NIDDM patients. 相似文献
15.
Zabun Nahar Mohammad Abul Kalam Azad Md Ashrafur Rahman Mohammad Arifur Rahman Wasimul Bari Sheikh Nazrul Islam Md Saiful Islam Abul Hasnat 《Biological trace element research》2010,133(3):284-290
The purpose of the study was to determine the serum concentration of trace elements of panic disorder patients and to find
out the relationship between trace element levels and nutritional status or socio-economic factors. The study was conducted
among 54 panic disorder patients and 52 healthy volunteers. Patients were recruited from Bangabandhu Sheikh Mujib Medical
University by random sampling. Serum trace element concentrations were determined by flame atomic absorption spectroscopy
(for Mg, Zn, Ca, and Cu) as well as graphite furnace (for Mn). Data were analyzed by independent t test, Pearson’s correlation analysis, regression analysis, and ANOVA. The serum concentration of Mn, Zn, Ca, Cu, and Mg in
panic disorder patients were 0.37 ± 0.30, 0.67 ± 0.20, 99.91 ± 15.15, 0.83 ± 0.23, and 21.14 ± 3.72 mg/L, while those were
0.4163 ± 0.2527, 0.86 ± 0.3, 106.6073 ± 18.6531, 0.8514 ± 0.3646, and 21.37 ± 2.03 mg/L in control subjects, respectively.
The serum concentration of Zn decreased significantly (p = 0.001) in patient group. But the differences of the concentration of Mn, Ca, Cu, and Mg between patient and control group
were not significant (p = 0.522, p = 0.065, p = 0.800, and p = 0.712, respectively). Socio-economic data reveal that most of the patients were very poor and middle aged. Mean BMIs of
the control group (23.74 ± 2.71 kg/m2) and the patient group (22.62 ± 3.74 kg/m2) were within the normal range (18.5–25.0 kg/m2). There was no significant relationship between serum zinc level and BMI of patients (r = 0.038; p = 0.809). So the decreased level of serum zinc in panic disorder patients was not because of other reasons, but rather it
may provide a prognostic tool for the diagnosis and treatment of this disease. 相似文献
16.
Letsiou S Nomikos T Panagiotakos D Pergantis SA Fragopoulou E Antonopoulou S Pitsavos C Stefanadis C 《Biological trace element research》2009,128(1):8-17
The trace element selenium is an essential micronutrient for human health and its low levels in serum are implicated in the
pathogenesis of several chronic diseases. Therefore, the determination of total selenium in serum may contribute to the assessment
of the health and nutritional status of certain populations. The objective of the present work was to determine total selenium
in the serum of 506 healthy volunteers that participated in the ATTICA study. Selenium was determined in serum by using the
technique of inductively coupled plasma mass spectrometry. The mean serum selenium concentration was determined to be 91.8 ± 33.7 μg/L
(N = 506); 87.6% of women and 88.5% of men had serum selenium concentration below 125 μg/L, the cutoff considered to be required
for optimal glutathione peroxidase activity. No association was found between serum selenium levels and the gender of the
participants while a significant decline of selenium with age (p < 0.0001) was observed. According to our results, no anthropometric, lifestyle, nutritional, or biochemical indices were
able to affect the association between serum selenium and age. This result may indicate that other factors such as selenium
distribution as well as retention may be affecting the relationship between serum selenium and age. 相似文献
17.
Maryam Pakfetrat Leila Malekmakan Mahshid Hasheminasab 《Biological trace element research》2010,137(3):335-339
In this cross-sectional study, selenium (Se) levels in the sera of 35 hemodialysis (HD) patients and 34 patients undergoing
continuous ambulatory peritoneal dialysis (CAPD) for more than 3 months were compared with the serum Se levels of 34 healthy
volunteers. The observed Se levels of 100.8 ± 51.9 μg/L in the sera of the HD patients and of 65.5 ± 32.1 μg/L in the sera
of the CAPD patients were significantly lower than the 134.9 ± 81.2 μg/L of the controls, with p = 0.002 and 0.02, respectively. Furthermore, the Se levels were significantly higher in the HD rather than the CAPD patients
(p = 0.01). In the spent dialysate effluent fluid of 32 of the CAPD patients Se was undetectable, in the remaining two CAPD
patients the Se levels were 1.9 and 4.6μg/l, respectively. The low Se levels of HD and CAPD patients as compared to healthy
persons are attributed to diminished Se retention due to chronic oxidative stress. 相似文献
18.
Asghar Ghasemi Saleh Zahediasl Leila Syedmoradi Fereidoun Azizi 《Biological trace element research》2010,136(1):18-25
This study aims at determining possible association between serum magnesium (Mg) concentrations and metabolic syndrome (MetS)
in elderly subjects. Subjects were 137 men and women aged 60 to 90 years, selected from among participants of the Tehran Lipid
and Glucose Study after excluding those taking medications for hypertension and dyslipidemia. Serum Mg levels were measured
by atomic absorption spectrometry and MetS was defined according to ATP III criteria. The overall prevalence of MetS was 43.8%.
Among MetS components, only plasma glucose showed a negative correlation with serum Mg concentrations (r = −0.194, p = 0.024). Subjects with MetS had significantly lower serum Mg concentrations compared with non-MetS ones (2.09 ± 0.03 vs.
2.18 ± 0.03 mg/dL, p = 0.033) even after adjustments with MetS components except for hyperglycemia (2.04 ± 0.06 vs. 2.20 ± 0.05 mg/dL, p = 0.011). However, after adjustment for hyperglycemia per se or along with the other MetS components, the significant difference
between serum Mg levels in subjects with and without MetS disappeared. In conclusion, serum Mg level is diminished in elderly
subjects with MetS, and hyperglycemia may play dominant role in this decrease; however, the results do not clarify whether
the low serum Mg level is a consequence of hyperglycemia or is a risk factor contributing to its development. 相似文献
19.
Fatemi Naieni F Ebrahimi B Vakilian HR Shahmoradi Z 《Biological trace element research》2012,146(1):30-34
Premature graying of hair with unclear etiology, which is known as premature canities, is a common cause of referrals to the
dermatologists. We assessed the relationship between serum iron, copper, and zinc concentrations with premature canities.
This study was conducted on patients under 20 years old suffering from premature canities, having a minimum of ten gray hair
fibers, and referring to university hospitals of Isfahan (Iran). The results were compared with age–sex-matched controls.
Demographic data and disease characteristics were recorded for two groups. We studied serum iron, copper, and zinc concentrations
of 66 patients and 66 controls using atomic absorption and Ferrozine methods. The mean age of studied cases was 17.8 ± 2.0 years,
and the mean age of the onset of canities was 15.5 ± 3.2 years with no significant difference between males and females (P > 0.05). Serum copper concentration was significantly lower in patients compared with controls (90.7 ± 37.4 vs. 105.3 ± 50.2 μg/dL,
P = 0.048), but serum iron concentration was significantly lower in controls compared to patients (88.8 ± 39.5 vs. 108.3 ± 48.4 μg/dL,
P = 0.008). Also, there was no significant difference between patients and controls in serum zinc concentration (114.8 ± 67.8
vs. 108.2 ± 49.9 μg/dL, P = 0.285). According to these results, among copper, zinc, and iron, a low serum copper concentration may play a role in premature
graying of hairs in our society. Further studies are needed to find the underlying mechanism of this relationship. 相似文献
20.
Mohan G Kulshreshtha S Dayal R Singh M Sharma P 《Biological trace element research》2007,118(2):184-190
Tuberculosis is a global problem especially in children, more so because of the difficulty in the diagnosis of the disease.
There are about 0.5 million deaths every year by this disease, worldwide. There are some reports that, during the disease,
there are changes in serum concentrations of zinc and copper, which reach towards normal levels during treatment. Such data
for children are scarce, especially in reference to India. Our study indicates that there is an insignificant to significant
rise in serum zinc levels in various age groups of children after antitubercular therapy (mean 61.89 ± 3.21 to 65.24 ± 3.60 μg/dl)
and significant fall in serum copper levels in different age groups of children (mean 129.96 ± 3.18 to 124.91 ± 3.48 μg/dl).
The Cu/Zn ratio also changed significantly from 2.11 ± 0.12 to 1.92 ± 0.12. Because evaluation of available diagnostic criteria
for primary complex in children has been found to have high sensitivity, and although this criterion is presently not recommended
for diagnosis of primary complex of children, further research can prove its utility in diagnosis and treatment of this disease. 相似文献