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Granger A Bleux C Kottler ML Rhodes SJ Counis R Laverrière JN 《Molecular endocrinology (Baltimore, Md.)》2006,20(9):2093-2108
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Miyamoto T Hasuike S Sengoku K Takuma N Hayashi H Sasaki Y Yamashita T Ishikawa M 《Development genes and evolution》2003,213(4):199-202
Mouse Spot-1 is a DNA-binding protein with a domain (His-Thr) encoded by p(CA)n repeats. Spot-1 interacts with the nuclear localization signal (NLS) I of p53 through its His-Thr domain. In this study we describe the cloning and expression patterns of a novel gene encoding a protein containing a His-Thr domain, Spot-2. Spot-2 is exclusively expressed in the pituitary from stage E13.5 to E15.5. Mouse Lhx3 plays a critical role during early organogenesis in the pituitary. The Spot-2 gene appears to be a downstream gene of Lhx3. It is suggested that Spot-2 plays important roles in pituitary development. 相似文献
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