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《Bioorganic & medicinal chemistry》2014,22(4):1459-1467
A series of novel N1-aryl-2-arylthioacetamido-benzimidazoles were synthesized and evaluated as inhibitors of human immunodeficiency virus type-1 (HIV-1). Some of them proved to be effective in inhibiting HIV-1 replication at submicromolar and nanomolar concentration acting as HIV-1 non-nucleoside RT inhibitors (NNRTIs), with low cytotoxicity. The preliminary structure–activity relationship (SAR) of these new derivatives was discussed and rationalized by docking studies. 相似文献
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Dai-Shi Su John J. Lim Elizabeth Tinney Bang-Lin Wan Mary Beth Young Kenneth D. Anderson Deanne Rudd Vandna Munshi Carolyn Bahnck Peter J. Felock Meiqing Lu Ming-Tain Lai Sinoeun Touch Gregory Moyer Daniel J. DiStefano Jessica A. Flynn Yuexia Liang Rosa Sanchez Sridhar Prasad Youwei Yan Neville J. Anthony 《Bioorganic & medicinal chemistry letters》2009,19(17):5119-5123
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Jiong Wang Robert A. Bambara Lisa M. Demeter Carrie Dykes 《Journal of virology》2010,84(18):9377-9389
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Arranz ME Díaz JA Ingate ST Witvrouw M Pannecouque C Balzarini J De Clercq E Vega S 《Bioorganic & medicinal chemistry》1999,7(12):2811-2822
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Ambrose Z Boltz V Palmer S Coffin JM Hughes SH Kewalramani VN 《Journal of virology》2004,78(24):13553-13561
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Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture 下载免费PDF全文
Archer RH Dykes C Gerondelis P Lloyd A Fay P Reichman RC Bambara RA Demeter LM 《Journal of virology》2000,74(18):8390-8401
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Denis J. Kertesz Christine Brotherton-Pleiss Minmin Yang Zhanguo Wang Xianfeng Lin Zongxing Qiu Donald R. Hirschfeld Shelley Gleason Taraneh Mirzadegan Pete W. Dunten Seth F. Harris Armando G. Villaseñor Julie Qi Hang Gabrielle M. Heilek Klaus Klumpp 《Bioorganic & medicinal chemistry letters》2010,20(14):4215-4218
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