LY3437943, a novel triple glucagon,GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept

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Metabolic evolution in response to interspecific competition in a eukaryote

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Late isocaloric eating increases hunger,decreases energy expenditure,and modifies metabolic pathways in adults with overweight and obesity

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Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet

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Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke

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GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation,Mitochondrial Integrity,and Function

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NaV1.2 EFL domain allosterically enhances Ca2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

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Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity

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Seabird morphology determines operational wind speeds,tolerable maxima,and responses to extremes

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Lyso-PAF,a biologically inactive phospholipid,contributes to RAF1 activation

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Newly Explored Faecalibacterium Diversity Is Connected to Age,Lifestyle, Geography,and Disease

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Leptin receptor-expressing pericytes mediate access of hypothalamic feeding centers to circulating leptin

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WeiTsing,a pericycle-expressed ion channel,safeguards the stele to confer clubroot resistance

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Redesigning HVEM Interface for Selective Binding to LIGHT,BTLA, and CD160

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Lipid peroxidation increases membrane tension,Piezo1 gating,and cation permeability to execute ferroptosis

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A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP,ADP, and the bisdioxopiperazine,ICRF193

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Sex and genetic background define the metabolic,physiologic, and molecular response to protein restriction

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Fast,cell-resolution,contiguous-wide two-photon imaging to reveal functional network architectures across multi-modal cortical areas

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