共查询到20条相似文献,搜索用时 31 毫秒
1.
Martinez M Ono N Planutiene M Planutis K Nelson EL Holcombe RF 《Cancer cell international》2012,12(1):2
Background
Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients receiving chemotherapy for metastatic colorectal cancer to determine if administration of GM-CSF in this setting was immunostimulatory. 相似文献2.
Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance 下载免费PDF全文
Kosuke Sakitani Toshihiro Nishizawa Masahide Arita Shuntaro Yoshida Yosuke Kataoka Daisuke Ohki Hiroharu Yamashita Yoshihiro Isomura Akira Toyoshima Hidenobu Watanabe Toshiro Iizuka Yutaka Saito Junko Fujisaki Naohisa Yahagi Kazuhiko Koike Osamu Toyoshima 《Helicobacter》2018,23(4)
Background
Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy.Materials and Methods
All‐cause death rates and gastric cancer‐specific death rates in gastric cancer patients who received successful H. pylori eradication treatment was tracked and compared to rates in patients who did not receive successful eradication therapy.Results
In total, 160 gastric cancer patients were followed‐up for up to 11.7 years (mean 3.5 years). Among them, 53 gastric cancer patients received successful H. pylori eradication therapy prior to gastric cancer diagnosis. During the follow‐up period, 11 all‐cause deaths occurred. In the successful eradication group, the proportion of patients with cancer stage I was higher. The proportions of patients who received curative endoscopic therapy and endoscopic examination in the 2 years prior to gastric cancer diagnosis were also higher in the successful eradication group. Kaplan–Meier analysis of all‐cause death and gastric cancer‐specific death revealed a lower death rate in patients in the successful eradication group (P = .0139, and P = .0396, respectively, log‐rank test). The multivariate analysis showed that endoscopy within 2 years before cancer diagnosis is associated with stage I cancer.Conclusions
Possible early discovery of gastric cancer after H. pylori eradication due to regular endoscopic surveillance may contribute to better prognosis of patients with gastric cancer. 相似文献3.
Background
Systematic approaches for identifying proteins involved in different types of cancer are needed. Experimental techniques such as microarrays are being used to characterize cancer, but validating their results can be a laborious task. Computational approaches are used to prioritize between genes putatively involved in cancer, usually based on further analyzing experimental data. 相似文献4.
Suzie E Ahn Jin Won Choi Deivendran Rengaraj Hee Won Seo Whasun Lim Jae Yong Han Gwonhwa Song 《Reproductive biology and endocrinology : RB&E》2010,8(1):100
Background
Cysteine cathepsins (CTSs) are involved in the degradation and remodeling of the extracellular matrix and are associated with cell transformation, differentiation, motility, and adhesion. These functions are also related to cancer cell invasion and metastasis. Chickens spontaneously develop epithelial ovarian cancer and are therefore a good animal model for human ovarian cancer. However, no studies have investigated the expression of CTSs in chickens with ovarian cancer. 相似文献5.
Background
Totally implantable central venous access devices (intraports) are commonly used in cancer patients to administer chemotherapy or parenteral nutrition. Rupture of intraport is a rare complication. 相似文献6.
Introduction
It is widely believed that discovery of specific, sensitive, and reliable tumor biomarkers can improve the treatment of cancer. Currently, there are no obvious targets that can be used in treating triple-negative breast cancer (TNBC). 相似文献7.
Background
Major issues in surgery for advanced ovarian cancer remain unresolved. Existing treatment guidelines are supported by a few published reports and fewer prospective randomized clinical trials. 相似文献8.
Lucia Taja-Chayeb Alma Chavez-Blanco Jorge Martínez-Tlahuel Aurora González-Fierro Myrna Candelaria Jose Chanona-Vilchis Elizabeth Robles Alfonso Dueñas-Gonzalez 《Cancer cell international》2006,6(1):22-11
Background
Despite significant achievements in the treatment of cervical cancer, it is still a deadly disease; hence newer therapeutical modalities are needed. Preliminary investigations suggest that platelet-derived growth factor (PDGF) might have a role in the development of cervical cancer, therefore it is important to determine whether this growth factor pathway is functional and its targeting with imatinib mesylate leads to growth inhibition of cervical cancer cells. 相似文献9.
Background
A central challenge in the molecular diagnosis and treatment of cancer is to define a set of molecular features that, taken together, distinguish a given cancer, or type of cancer, from all normal cells and tissues. 相似文献10.
Jan B Howes Paul L de Souza Leanne West Li Jiu Huang Laurence G Howes 《BMC clinical pharmacology》2011,11(1):1
Background
Phenoxodiol is a novel isoflavone currently being studied in clinical trials for the treatment of cancer. This study reports the pharmacokinetics of phenoxodiol in patients with cancer. 相似文献11.
Background
Cancer of the oral tongue is the second most common cancer among males in various parts of India. Despite advances in diagnosis and treatment the failure rates in cancer of the oral tongue are high and survival poor. Majority of these failures occur in untreated neck. 相似文献12.
Background
Proteomic data obtained from mass spectrometry have attracted great interest for the detection of early-stage cancer. However, as mass spectrometry data are high-dimensional, identification of biomarkers is a key problem. 相似文献13.
Wright ME Eng J Sherman J Hockenbery DM Nelson PS Galitski T Aebersold R 《Genome biology》2003,5(1):R4
Background
Androgens play a critical role in the development of prostate cancer-dysregulation of androgen-regulated growth pathways can led to hormone-refractory prostate cancer. A comprehensive understanding of androgen-regulated cellular processes has not been achieved to date. To this end, we have applied a large-scale proteomic approach to define cellular processes that are responsive to androgen treatment in LNCaP prostate cancer cells. 相似文献14.
Yi Li Katrina Podsypanina Xiufan Liu Allison Crane Lee K Tan Ramon Parsons Harold E Varmus 《BMC molecular biology》2001,2(1):2-9
Background
Germline mutations in the tumor suppressor PTEN predispose human beings to breast cancer, and genetic and epigenetic alterations of PTEN are also detected in sporadic human breast cancer. Germline Pten mutations in mice lead to the development of a variety of tumors, but mammary carcinomas are infrequently found, especially in mice under the age of six months. 相似文献15.
Tim J Dexter David Sims Costas Mitsopoulos Alan Mackay Anita Grigoriadis Amar S Ahmad Marketa Zvelebil 《BMC systems biology》2010,4(1):127
Background
Genomic copy number changes and regional alterations in epigenetic states have been linked to grade in breast cancer. However, the relative contribution of specific alterations to the pathology of different breast cancer subtypes remains unclear. The heterogeneity and interplay of genomic and epigenetic variations means that large datasets and statistical data mining methods are required to uncover recurrent patterns that are likely to be important in cancer progression. 相似文献16.
17.
Background
Breast cancer is the most common cause of cancer death in the western world. The expression differences of many proteins are associated with breast cancer progression or suppression. The purpose of the study was to determine the expression of nm23 protein in the invasion status and metastatic potential of breast cancer by using tissue microarray and to determine its role in breast cancer based on the expression of nm23 gene product. 相似文献18.
The association of garlic with Helicobacter pylori infection and gastric cancer risk: A systematic review and meta‐analysis 下载免费PDF全文
Background
Garlic may be protective against Helicobacter pylori infection and gastric cancer development. We conducted this study to quantitatively update evidence on garlic intake and gastric cancer with the inclusion of most recent cohort studies and qualitatively summarize epidemiological studies of garlic consumption and Helicobacter pylori infection.Materials and Methods
PubMed, Embase, MEDLINE, and Cochrane Library were searched on April 2018. We conducted a meta‐analysis to determine whether garlic intake reduced gastric cancer risk using random‐effect models and a systematic review to summarize evidence on the association between garlic consumption and Helicobacter pylori infection. Risk of bias was assessed using tools of Cochrane risk of bias and Robins‐I for randomized and nonrandomized studies, respectively.Results
Meta‐analysis of 18 studies (142 921 subjects) demonstrated high garlic consumption (as comparing the highest category to the lowest) was associated with a reduced gastric cancer risk (OR = 0.51, 95% CI = 0.44‐0.57). This association became nonsignificant if only derived from the prospective studies (OR = 0.95, 95% CI = 0.66‐1.24). Thirteen studies (4889 participants) were included in the systematic review for garlic consumption and Helicobacter pylori infection; ten of which found no significant results. The majority of these studies were poor in quality given the small sample size and high risk of bias.Conclusions
Pooled evidence, mainly from case‐control studies, suggested a significant inverse association of garlic intake with gastric cancer risk. Given the limitations of included studies, current epidemiological evidence is not sufficient to reach any definite conclusion regarding the association of garlic with Helicobacter pylori infection. 相似文献19.
Jayesh Sagar Kevin Sales Jan-Willem Taanman Sas Dijk Marc Winslet 《Cancer cell international》2010,10(1):31
Background
Colorectal cancer is the third most-common cancer and the second most-common cause of cancer related death in UK. Although chemotherapy plays significant role in the treatment of colorectal cancer, morbidity and mortality due to drug resistance and cancer metastasis are yet to be eliminated. Recently, doxycycline has been reported to have cytotoxic and anti-proliferating properties in various cancer cells. In this study, whether doxycycline was apoptosis threshold lowering agent in colorectal cancer cells by targeting mitochondria was answered. 相似文献20.
Hsi-Hsien Hsu Wei-Syun Hu Yueh-Min Lin Wei-Wen Kuo Li-Mien Chen Wei-Kung Chen Jin-Ming Hwang Fuu-Jen Tsai Chung-Jung Liu Chih-Yang Huang 《Journal of biomedical science》2011,18(1):61