共查询到20条相似文献,搜索用时 31 毫秒
1.
Highlights? Trachea-derived Dpp/Bmp is required for midgut homeostasis ? Dpp expressed in tracheal cells reach intestinal cells through visceral muscles ? Dpp signaling is activated in enterocytes (ECs) in the Drosophila adult midgut ? Dpp signaling stabilizes ECs to restrict intestinal stem cell proliferation 相似文献
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Sebastian Lugert Onur Basak Philip Knuckles Ute Haussler Klaus Fabel Magdalena Götz Carola A. Haas Gerd Kempermann Verdon Taylor Claudio Giachino 《Cell Stem Cell》2010,6(5):445-456
Highlights? Notch signaling defines morphologically distinct hippocampal stem cell populations ? Radial and horizontal hippocampal stem cells depend on canonical Notch signaling ? Different neural stem cell subpopulations respond selectively to neurogenic stimuli ? Aging results in a reversible transition of stem cells to a quiescent state 相似文献
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François Binet Gaëlle Mawambo Nicholas Sitaras Nicolas Tetreault Eric Lapalme Sandra Favret Agustin Cerani Dominique Leboeuf Sophie Tremblay Flavio Rezende Aimee M. Juan Andreas Stahl Jean-Sebastien Joyal Éric Milot Randal J. Kaufman Martin Guimond Timothy E. Kennedy Przemyslaw Sapieha 《Cell metabolism》2013,17(3):353-371
Highlights? Canonical ER stress pathways are activated in central neurons during hypoxia/ischemia ? The ER stress endoribonuclease IRE1α degrades the neurovascular guidance cue netrin-1 ? Neuronal-derived netrin-1 activates a reparative proangiogenic program in microglial cells ? Neuronal ER stress prevents reparative angiogenesis in the ischemic neural retina 相似文献
4.
Takayuki Kondo Masashi Asai Kayoko Tsukita Yumiko Kutoku Yutaka Ohsawa Yoshihide Sunada Keiko Imamura Naohiro Egawa Naoki Yahata Keisuke Okita Kazutoshi Takahashi Isao Asaka Takashi Aoi Akira Watanabe Kaori Watanabe Chie Kadoya Rie Nakano Dai Watanabe Haruhisa Inoue 《Cell Stem Cell》2013,12(4):487-496
Highlights? Familial and sporadic Alzheimer’s patient iPSC-derived neural cells were analyzed ? Intracellular Aβ oligomers accumulate in lines from some patients ? Aβ oligomer accumulation is associated with ER and oxidative stress ? DHA-alleviated ER and oxidative stresses improve cell viability 相似文献
5.
Anne-Laure Huber Justine Lebeau Patricia Guillaumot Virginie Pétrilli Mouhannad Malek Julien Chilloux Frédérique Fauvet Léa Payen Alain Kfoury Toufic Renno Eric Chevet Serge N. Manié 《Molecular cell》2013,49(6):1049-1059
Highlights? Transformation-associated glucose shortage triggers ER stress ? The ER stress acts as barrier to malignancy by triggering UPR-dependent apoptosis ? p58IPK expression removes the UPR barrier by attenuating its PERK-CHOP branch ? This adaptive mechanism enables implementation of UPR cytoprotective features 相似文献
6.
Pengcheng Bu Kai-Yuan Chen Joyce Huan Chen Lihua Wang Jewell Walters Yong Jun Shin Julian P. Goerger Jian Sun Mavee Witherspoon Nikolai Rakhilin Jiahe Li Herman Yang Jeff Milsom Sang Lee Warren Zipfel Moonsoo M. Jin Zeynep H. Gümüş Steven M. Lipkin Xiling Shen 《Cell Stem Cell》2013,12(5):602-615
Highlights? miR-34a regulates colon cancer stem cell asymmetric division ? miR-34a generates a sharp threshold response ? miR-34a converts Notch signaling into a toggle switch ? Binary Notch levels specify self-renewal versus differentiation 相似文献
7.
Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
Sarah Schwitalla Alexander A. Fingerle Patrizia Cammareri Tim Nebelsiek Serkan I. Göktuna Paul K. Ziegler Ozge Canli Jarom Heijmans David J. Huels Guenievre Moreaux Rudolf A. Rupec Markus Gerhard Roland Schmid Nick Barker Hans Clevers Roland Lang Jens Neumann Thomas Kirchner Florian R. Greten 《Cell》2013,152(1-2):25-38
Highlights? Epithelial nonstem cells can be reprogrammed into tumor-initiating cells ? Dedifferentiation depends on degree of Wnt signaling ? Wnt signaling is enhanced by NFkB via the coactivator CBP ? Differentiation of stem cells into nonstem cells is bidirectional 相似文献
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Encinas JM Michurina TV Peunova N Park JH Tordo J Peterson DA Fishell G Koulakov A Enikolopov G 《Cell Stem Cell》2011,8(5):566-579
Highlights? The neural stem cell pool declines over time during aging ? Neural stem cell activation prompts rapid asymmetric divisions ? After undergoing division, neural stem cells differentiate into astrocytes 相似文献
10.
Swetlana Sirko Gwendolyn Behrendt Pia Annette Johansson Pratibha Tripathi Marcos Romualdo Costa Sarah Bek Christophe Heinrich Steffen Tiedt Dilek Colak Martin Dichgans Isabel Rebekka Fischer Nikolaus Plesnila Matthias Staufenbiel Christian Haass Marina Snapyan Armen Saghatelyan Li-Huei Tsai André Fischer Magdalena Götz 《Cell Stem Cell》2013,12(4):426-439
Highlights? Stab wound injury and MCAo elicit a profound stem cell response ? Noninvasive brain injury fails to elicit a stem cell response ? SHH is upregulated and required in lesion conditions with a stem cell response ? SHH transducer deletion in astrocytes reduces their proliferative response to injury 相似文献
11.
Bin Wu Alys Peisley Claire Richards Hui Yao Xiaohui Zeng Cecilie Lin Feixia Chu Thomas Walz Sun Hur 《Cell》2013,152(1-2):276-289
Highlights? MDA5 forms an open, C-shaped ring around the viral dsRNA stem ? The CTD of MDA5 has a different orientation and flexibility compared to RIG-I ? MDA5 forms filaments by stacking monomers head-to-tail with a 70° turn per monomer ? The 2CARD domain assembles into oligomers that activate interferon signaling via MAVS 相似文献
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Amy Leung Aldo Ciau-Uitz Philip Pinheiro Rui Monteiro Jie Zuo Paresh Vyas Roger Patient Catherine Porcher 《Developmental cell》2013,24(2):144-158
Highlights? VEGFA short isoform supports endothelial/arterial development of the dorsal aorta ? ETO2 maintains high levels of VEGFA medium and long isoforms in the somites ? VEGFA medium isoform instructs the blood program in blood stem cell precursors ? ETO2 specifies blood stem cells in a non-cell-autonomous manner 相似文献
14.
Justus Veerkamp Franziska Rudolph Zoltan Cseresnyes Florian Priller Cécile Otten Marc Renz Liliana Schaefer Salim Abdelilah-Seyfried 《Developmental cell》2013,24(6):660-667
Highlights? Cardiac laterality involves Nodal modulating an antimotogenic Bmp activity ? The Nodal target Hyaluronan synthase 2 unilaterally dampens Bmp signaling activity ? Nonmuscle myosin II is positively regulated by Bmp within cardiac tissue ? High levels of nonmuscle myosin II activity reduce cardiac cell motility 相似文献
15.
Highlights? Regeneration of midbrain dopamine neurons depends on decreased dopamine signaling ? L-dopa inhibits ependymoglia cell proliferation during dopamine neuron regeneration ? Proliferation of ependymoglia cells is constantly suppressed by dopamine signaling ? Inhibition of dopamine signaling evokes neurogenesis by quiescent ependymoglia cells 相似文献
16.
Highlights? The endoplasmic reticulum (ER) in dendrites shows spatial variation in complexity ? Increased complexity occurs at dendritic branch points, confining membrane cargo ? An mGluR/PKC/CLIMP63 pathway bidirectionally regulates ER complexity ? ER complexity controls dendritic morphogenesis and defines sites of branch formation 相似文献
17.
Sang Gyun Kim Gregory R. Hoffman George Poulogiannis Gwen R. Buel Young Jin Jang Ki Won Lee Bo-Yeon Kim Raymond L. Erikson Lewis C. Cantley Andrew Y. Choo John Blenis 《Molecular cell》2013,49(1):172-185
Highlights? Glucose and glutamine feed back to promote mTORC1 signaling through ATP production ? Energetic stress prevents mTOR lysosomal localization independently of AMPK and Rag ? ATP-dependent TTT-RUVBL complex is disassembled and repressed by energetic stress ? TTT-RUVBL is required for mTORC1 functional assembly and lysosomal localization 相似文献
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Highlights? Drosophila Matrix Metalloprotease (Mmp) inhibits FGF signaling ? An FGF – MMP feedback loop regulates branching morphogenesis ? Mmp2 spatially regulates FGF signaling in epithelia 相似文献
19.
Highlights? Endodermal EpCAM cell autonomously modulates the Wnt2bb-induced hepatic development ? EpCAM directly binds to Kremen1 and disrupts the Kremen1-Dkk2 interaction ? EpCAM derepresses Lrp6 and allows Lrp6 clustering into active signalosomes ? EpCAM licenses and cooperatively activates Wnt2bb signaling in the endoderm 相似文献
20.
Jason M. Butler Daniel J. Nolan Eva L. Vertes Barbara Varnum-Finney Hideki Kobayashi Andrea T. Hooper Marco Seandel Koji Shido Ian A. White Mariko Kobayashi Larry Witte Chad May Carrie Shawber Yuki Kimura Jan Kitajewski Zev Rosenwaks Irwin D. Bernstein Shahin Rafii 《Cell Stem Cell》2010,6(3):251-264
Highlights? Coculture with endothelial cells promotes HSC expansion and self-renewal ? Endothelial cell effect on HSCs mediated by Notch signaling ? In vivo, sinusoidal endothelial cells (SECs) express Notch ligands ? Blocking vessel remodeling impairs hematopoietic recovery after irradiation 相似文献