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1.
Molnar J Garamvolgyi Z Herold M Adanyi N Somogyi A Rigo J 《Biological trace element research》2008,121(1):16-22
Selenium is an essential trace element and a component of various enzymes with antioxidant functions. High-sensitive C-reactive
protein (hsCRP) is an early indicator of increased lipid peroxidation. The serum selenium concentration, lipid parameters,
and hsCRP values of gestational diabetic pregnant women (GD), control pregnant women (CP), and healthy nonpregnant controls
(HC) were compared. Blood was taken between the 24th and the 28th week of pregnancy when the oral glucose tolerance test was
performed. Selenium concentration was determined by atomic absorption spectrometry after hydride generation. HsCRP was measured
by immunturbidimetry. HC had significantly higher serum selenium concentrations than GD and CP women (HC = 77.4 ± 14.82, GD = 51.7 ± 11.62,
and CP = 40.5 ± 8.03 μg/l, respectively). HsCRP values of both GD and nondiabetic pregnant women were significantly higher
compared to controls. Significant negative correlations were found between serum selenium and total cholesterol, low-density
lipoprotein cholesterol, and hsCRP values indicating that low selenium levels are associated with increased lipid peroxidation.
Serum selenium concentrations of Hungarian pregnant women are low compared to internationally published data. 相似文献
2.
Wayne Chris Hawkes Calvin C. Willhite Kimberly A. Craig Stanley T. Omaye Douglas N. Cox Wai Nang Choy Andrew G. Hendrickx 《Biological trace element research》1992,35(3):281-297
Forty pregnant long-tailed macaques were treated daily for 30 d with 0, 25, 150 or 300 μg selenium as L-selenomethionine/kg
body weight. Erythrocyte and plasma selenium and glutathione peroxidase specific activities, hair and fecal selenium, and
urinary selenium excretion were increased by and were linearly related to L-selenomethionine dose. Hair selenium was most
sensitive to L-selenomethionine dose, with an 84-fold increase in the 300 μg selenium/(kg-d) group relative to controls (r=0.917). Daily urinary selenium excretion (80-fold,r=0.958), plasma selenium (22-fold,r=0.885), erythrocyte selenium (24-fold,r=0.920), and fecal selenium (18-fold,r=0.911) also responded strongly to L-selenomethionine. Erythrocyte and plasma glutathione peroxidase specific activities increased
154% and 69% over controls, respectively. Toxicity was associated with erythrocyte selenium >2.3 μg/mL, plasma selenium >2.8
μg/mL, and hair selenium >27 μg/g. Plasma, erythrocyte, and hair selenium concentrations may be useful for monitoring and
preventing the toxicity of L-selenomethionine administered to humans in cancer chemoprevention trials. 相似文献
3.
Usuda K Kono K Shimbo Y Fujihara M Fujimoto K Kawano A Kono R Tsuji H Tanida E Imanishi M Fukuda C Suzuki S Tanaka H 《Biological trace element research》2007,119(1):27-34
As fluoride has a very short half-life in the body and the major route for fluoride excretion is via the kidney, human exposure
is best measured in urine, where the concentration is expected to be highest. The urinary fluoride concentrations of 167 healthy
Japanese adults were determined by means of a fluoride ion selective electrode. When the results were corrected for a specific
gravity ρ = 1.024 g cm−3, the histogram of urinary fluoride concentrations highly skewed toward low values with sharp peakedness (skewness = 1.56,
kurtosis = 3.08). The normality of the log-transformed histogram (skewness = 0.12, kurtosis = 0.07) and the straight line
on log-probability paper clearly showed a key feature of lognormal distribution of urinary fluoride. A geometric mean (GM)
of 613.8 μg/l and 95% confidential interval (CI) of 241.0–1633.1 μg/l were established as reference values for urinary fluoride.
The results presented in this study will be useful as guidelines for the biological monitoring of fluoride in normal subjects
and individuals at risk of occupational or environmental fluoride exposure. 相似文献
4.
Selenium helps protect against peroxidation during aging as part of the glutathione peroxidase (GPx) antioxidant system. Selenium
status, however, is often low in elderly persons who have low selenium intake, live in institutions, and have certain chronic
diseases. In addition, a relationship has been observed between the female reproductive hormone, estrogen, and selenium status,
with blood selenium and GPx activity coinciding with fluctuations in estrogen during the menstrual cycle. These findings suggest
that the decrease in estrogen following menopause may cause a decrease in selenium status, and thus accelerate the process
of aging and increase the risk of certain diseases. The current study compared selenium status in healthy premenopausal (n = 13, 21 to 43 years) and postmenopausal (n = 10, 57 to 86 years) women. Selenium intakes of both groups were similar and greater than the recommended dietary allowance
(RDA) of 55 μg/day for adult women. Although neither plasma nor RBC selenium concentrations were significantly different between
groups, postmenopausal women had significantly greater plasma (p < 0.02), and RBC (p < 0.05) GPx activities compared to premenopausal women possibly in response to oxidative processes associated with aging.
These results indicate that the selenium status of healthy postmenopausal women did not decline with menopause and that their
antioxidant capability, as measured by GPx activity, was preserved with dietary intake of selenium greater than the RDA.
Presented in part at the Experimental Biology 2000, April 2000, San Diego, CA [Smith AM, Ha EJ, Medeiros LC. Selenium-dependent
glutathione peroxidase activity is increased in healthy post-menopausal women. FASEB J 2000;14:A513.]. 相似文献
5.
6.
Letsiou S Nomikos T Panagiotakos D Pergantis SA Fragopoulou E Antonopoulou S Pitsavos C Stefanadis C 《Biological trace element research》2009,128(1):8-17
The trace element selenium is an essential micronutrient for human health and its low levels in serum are implicated in the
pathogenesis of several chronic diseases. Therefore, the determination of total selenium in serum may contribute to the assessment
of the health and nutritional status of certain populations. The objective of the present work was to determine total selenium
in the serum of 506 healthy volunteers that participated in the ATTICA study. Selenium was determined in serum by using the
technique of inductively coupled plasma mass spectrometry. The mean serum selenium concentration was determined to be 91.8 ± 33.7 μg/L
(N = 506); 87.6% of women and 88.5% of men had serum selenium concentration below 125 μg/L, the cutoff considered to be required
for optimal glutathione peroxidase activity. No association was found between serum selenium levels and the gender of the
participants while a significant decline of selenium with age (p < 0.0001) was observed. According to our results, no anthropometric, lifestyle, nutritional, or biochemical indices were
able to affect the association between serum selenium and age. This result may indicate that other factors such as selenium
distribution as well as retention may be affecting the relationship between serum selenium and age. 相似文献
7.
Teng X Shi X Shan Z Jin Y Guan H Li Y Yang F Wang W Tong Y Teng W 《Biological trace element research》2008,121(1):23-30
Iodine excess may lead to thyroid diseases. Our previous 5-year prospective survey showed that the prevalence and incidence
of hypothyroidism or autoimmune thyroiditis increased with iodine intake. The aim of the present study was to investigate
the optimal range of iodine intake by comparing the prevalence of thyroid diseases in three areas with slightly different
levels of iodine intake. In 2005, 778 unselected women subjects from three areas with different iodine intake levels were
enrolled. Levels of serum thyroid hormones, thyroid autoantibodies, and urinary iodine were measured, and thyroid B ultrasounds
were performed. Among the subjects with mildly deficient iodine intake, those with adequate intake, and those with more than
adequate intake, the prevalence of clinical and subclinical hypothyroidism was 0, 1.13, and 2.84%, respectively (P = 0.014); that of thyroid goiter was 24.88, 5.65, and 11.37%, respectively (P < 0.001); that of serum thyrotropin values was1.01, 1.25, and 1.39 mIU/l, respectively; and that of serum thyrotropin/thyroglobulin
ratio was 7.98, 6.84, and 5.11, respectively (P < 0.001). In conclusion, median urinary iodine 100~200 μg/l may reflect the safe range of iodine intake levels. Serum thyrotropin/thyroglobulin
ratio might be a better index of evaluating iodine status. 相似文献
8.
Three models were used to determine the daily dietary Selenium intake in Slovakia. The Selenium content of food produced and
consumed in the Slovak Republic was used to estimate and calculate the daily Selenium intake based on food consumption data
per capita and seven days, (24 h) eating protocol models. In a duplicate portion model, Selenium was analyzed in a whole day
hospital diet during an eight-day period. According to these models the daily dietary Selenium intake was 38.2 μg; 43.3 ±6.5
μg for men and 32.6 ±6.6 μg for women; 27.1 ±7.8 μg for normal and 32.3 ±4.8 μg for nourishing hospital diets. The main contributors
of Selenium to daily intake were the following: eggs, pork, and poultry. The obtained results indicate that the daily dietary
intake of Selenium of the Slovak people is below the recommended values. 相似文献
9.
Jetmund Ringstad Synnøve F. Knutsen Odd R. Nilssen Yngvar Thomassen 《Biological trace element research》1993,36(1):65-71
Depressed selenium and Vitamin E levels may contribute to hepatic injury through lipid peroxidation. To study the effect of
moderate alcohol drinking (32.4±23.6 g ethanol/d) on serum selenium and serum vitamin E concentrations, we conducted a matched-pair
study of 73 healthy, well-nourished risk drinkers and healthy controls with little or no alcohol consumption. Among risk drinkers,
serum selenium was significantly lowered (1.49 vs 1.67 μmol/L;p<0.001) compared with controls. Difference in α-tocopherol concentrations did not, however, reach statistical significance
(22.8 vs 24.9 μmol/L;p=0.06). Nutritional and life-style factors differed very little between the two groups. We conclude that even moderate alcohol
consumption lowers selenium status. Selenium may thus represent a link joining the hepatotoxic and nutritional backgrounds
of alcoholic liver disease. 相似文献
10.
Bogumiła Pilarczyk Diana Hendzel Renata Pilarczyk Agnieszka Tomza-Marciniak Barbara Błaszczyk Marta Dąbrowska-Wieczorek Małgorzata Bąkowska Ewa Adamowicz Tomasz Bujak 《European Journal of Wildlife Research》2010,56(5):797-802
The aim of this study was to determine liver and kidney concentrations of selenium in wild boars from the northwest part of
Poland, depending on season of the year, age, sex, and body weight. Altogether, samples of livers and kidneys from 172 wild
boars that were shot in 2005–2008 were investigated. Liver and kidney concentrations of selenium were determined using spectrofluorometric
method. In all the animals studied, selenium concentration was several times lower in the liver than in the kidneys. Selenium
concentration averaged 0.19 μg/g wet weight (w.w.) in the liver and 1.20 μg/g w.w. in kidneys. The present study showed that
season (P ≤ 0.05), age (P ≤ 0.01), and body weight (P ≤ 0.01) have a significant effect on selenium concentration in the liver of wild boars. Liver selenium concentration was
the highest in spring (0.23 μg/g w.w.) and the lowest in autumn (0.16 μg/g w.w). Young animals (up to 1 year of age) and those
with the lowest body weight (up to 20 kg) were characterized by a slightly lower selenium concentration in the liver compared
to older and heavier animals. No significant differences were found in organ selenium concentration between males and females.
According to biochemical criteria for the diagnosis of selenium deficiency in pig liver, which were used to evaluate selenium
concentration in the liver of wild boars, no individuals were found to have optimal levels. Considering that in Se deficiency
higher selenium concentrations are found in kidneys than in the liver, it can be presumed that the wild boars had Se deficiency.
However, this is difficult to state conclusively because there are no reference values for this species. 相似文献
11.
Nisianakis P Giannenas I Gavriil A Kontopidis G Kyriazakis I 《Biological trace element research》2009,128(1):62-71
The effect of two different doses of selenium [1 and 50 μg selenium/100 g body weight (wt)] on nicotine-induced oxidative
damage in liver was investigated in experimental rats. Male albino rats were maintained for 60 days as follows: (1) control
group (normal diet), (2) nicotine group (0.6 mg/kg body wt)/day, (3) high-dose selenium (50 μg/100 g body wt)/day, (4) high-dose
selenium (50 μg/100 g body wt) + nicotine (0.6 mg/kg body wt)/day, (5) low-dose selenium (1 μg/100 g body wt)/day, and (6)
low-dose selenium (1 μg/100 g body wt) + nicotine (0.6 mg/kg body wt)/day. Nicotine administration caused a decrease in the
activity of antioxidant enzymes, an increase in the concentration of lipid peroxidation products and protein carbonyls and
an increase in the activity of nitric oxide synthase compared to the control group. Coadministration of nicotine and selenium
reduced the concentration of lipid peroxidation products and increased the activity of antioxidant enzymes compared to the
nicotine group. Selenium also enhanced the metabolism of nicotine. The antioxidant effect was more significant in the group
administered a low dose of selenium. 相似文献
12.
Selenium concentrations in the blood of 112 (56 females and 56 males) normal subjects, from different regions of the Punjab
(Pakistan), have been determined using the technique of inductively coupled plasma-mass spectrometry. The whole blood selenium
concentrations were found to be 452 ± 12 ppb (parts per billion or nano-gram of Se per gram freeze-dried blood or 96 ± 3 μg/L
), with 470 ± 16 ppb (or 100 ± 4 μg/L) in female and 435 ± 16 ppb (or 92 ± 4 μg/L) in male population. Compared with other
populations of the world, these levels are amongst the lowest. 相似文献
13.
Tohidi M Ghasemi A Hadaegh F Arbabi S Hosseini Isfahani F 《Biological trace element research》2011,143(2):835-843
This study aims at determining the association between markers of hepatic injury and serum, urinary, and intra-erythrocyte
magnesium concentrations and dietary magnesium intake in obese children and adolescents. In a case–control study, 42 obese
children and adolescents (8–18 years) and 42 sex- and puberty-matched controls were studied. Serum, urinary, and intra-erythrocyte
magnesium levels, indices of insulin sensitivity, and liver enzymes were measured. Dietary magnesium intake was assessed using
a food frequency questionnaire. Obese children and adolescents exhibited insulin resistance as determined by a higher fasting
insulin and the HOMA-IR (p < 0.001) and lower QUICKI indices (p = 0.001); in addition these subjects had significantly higher intra-erythrocyte magnesium (IEM) concentrations, than non-obese
ones (3.99 ± 1.05 vs. 3.35 ± 1.26 mg/dL of packed cell; p = 0.015). Among liver enzymes, only gamma-glutamyl transferase (GGT) was significantly higher in obese than in non-obese
subjects (22.7 ± 9.4 vs. 17.1 ± 7.9 U/l; p = 0.002). A positive association was found between GGT and IEM in both groups; however in multivariate analysis, in obese
subjects, only GGT (p = 0.026) and, in non-obese subjects, only age (p = 0.006) remained as significant predictors of IEM. In conclusion, increased IEM concentration was seen in insulin-resistant
obese children and adolescents; furthermore, serum GGT was associated with IEM, independently of body mass index and HOMA-IR. 相似文献
14.
Antti Aro Jorma Kumpulainen Georg Alfthan Anatoly V. Voshchenko Vladimir N. Ivanov 《Biological trace element research》1994,40(3):277-285
The selenium concentration in foods grown and consumed and in plasma, red blood cells, and toenails of people living in the
district of Chita in the transbaikalian part of Russia were studied in August 1991. Preliminary results from the area have
suggested low selenium intakes and the possible occurrence of cardiomyopathy (Keshan disease) in the population. A low selenium
concentration in foods grown locally was found: mean selenium concentration in wheat grains was 1, 5, and 28 μg/kg, respectively,
in three villages studied, that of oats was beween 3–6 μg/kg, and of cow's milk 10–27 μg/kg dry matter. The selenium concentration
of bread was considerably higher, between 87–337 μg/kg dry wt, presumably because wheat imported from the US had been used
for baking. Occasional samples of pork, beef, and mutton contained between 32–318 μg selenium/kg dry wt. Low selenium concentrations
were observed in samples of soil and river water. The mean plasma selenium concentration of 52 persons was 1.02 μmol/L, including
33 children and 19 adult subjects. The selenium concentrations in red blood cells and toenails were 1.95 μmol/L and 0.61 mg/kg,
respectively. No symptoms of heart disease caused by selenium deficiency were observed. It is concluded that the selenium
status of people was fairly good thanks to the contribution to dietary intake of imported wheat with a high selenium content.
As the selenium concentration was very low in foods grown in the area, the selenium intake of the population will be reduced
to a very low level if only locally produced foods are consumed. 相似文献
15.
16.
Marreiro DN do Perpetuo Socorro C Martins M de Sousa SS Ibiapina V Torres S Pires LV do Nascimento Nogueira N Lima JM do Monte SJ 《Biological trace element research》2007,120(1-3):42-50
The objective of this study was to assess urinary excretion of zinc and evaluation parameters of metabolic control in type
2 diabetic patients. Thirty-one type 2 diabetic patients, of both genders, with 5.8 ± 5.6 years average time of the disease,
age range 20–60 years, were selected. Evaluation of the nutritional status was performed using anthropometric measurements.
To evaluate food consumption, the 3-day alimentary log method was used, and its analysis was performed using a software. Determination
of urinary zinc was by atomic absorption spectrophotometry. From the obtained results, it was concluded that 51.6% of the
patients were overweight. The mean of found waist circumference was 100.4 and 92.2 cm for men and women, respectively. Blood
glucose and glycated hemoglobin values were higher than reference values, and plasma albumin concentration was adequate. The
median of found urinary zinc excretion was 474.9 μg/24 h, within normal standards (300–600 μg/day). Regarding diet composition,
calorie and protein concentration were above recommendation, while mean zinc concentration was adequate. This data allow the
conclusion that the evaluated patients presented adequate urinary zinc excretion in comparison with reference values. 相似文献
17.
Determination of copper in human tissues and body fluids may be crucial in the diagnosis of Wilson’s disease. In this study
we evaluated urinary copper excretion and urine and blood concentration in 14 patients in whom Wilson’s disease was confirmed
(group A) and in 21 subjects in whom the disease was only suspected (group B). The following values (mean ± SD) were found:
24-h urine (μg Cu/24 h), 152 ± 135 (A) and 31.8 ± 10.9 (B); urine (μg Cu/ml), 0.091 ± 0.087 (A) and 0.028 ± 0.011 (B); and
blood (μg Cu/ml), 0.62 ± 0.25 (A) and 0.72 ± 0.09 (B). By comparison, urine copper concentration in the group of apparently
healthy subjects was 0.035 ± 0.010 (n = 50), and blood copper concentration in autopsy cases of nonpoisoned people was 0.85 ± 0.19 (n = 73). 相似文献
18.
Characteristics of Se-Enriched Mycelia by Stropharia rugoso-annulata and its Antioxidant Activities in vivo 总被引:1,自引:0,他引:1
Zhen Song Le Jia Feng Xu Fanyun Meng Peng Deng Keming Fan Xiaonan Liu 《Biological trace element research》2009,131(1):81-89
Selenium (Se) is an essential trace element for humans and animals. Stropharia rugoso-annulata is a nutritional and functional mushroom containing many kinds of bioactive ingredients. The aims of this study were to investigate
the Se-enrichment characteristics of S. rugoso-annulata in submerged culture and evaluate the antioxidant activities of Se-enriched mycelia in vivo in terms of the values of glutathione
peroxidase (GSH-Px), superoxide dismutase (SOD), and malondialdehyde (MDA). The optimum parameters of Se-enrichment under
the optimal Se concentration (150 μg/mL) in media were as follows: biomass 8.11 ± 0.25 g/L, Se content in mycelia 4,727.68 ± 13 μg/g,
Se-accumulated rate 24.68 ± 1.67%, and percentage of organic Se 96.27 ± 3.26%. The mainly subsistent forms of selenium in
Se-enriched mycelia were selenoprotein and selenium-polysaccharide. The contents of total amino acids (TAA) and essential
amino acids (EAA) in Se-enriched mycelia were increased by 13.5 ± 1.09% and 12.8 ± 0.89%, respectively. It was efficient for
Se-enriched mycelia to elevate GSH-Px and SOD activities and decrease MDA content. These results indicated that Se-enriched
mycelia of S. rugoso-annulata represent a novel dietary source of bioavailable supplemental selenium. 相似文献
19.
Kłapcińska B Poprzecki S Danch A Sobczak A Kempa K 《Biological trace element research》2005,108(1-3):1-15
The selenium status and the relationship of whole-blood selenium and plasma homocysteine are reported for healthy human subjects
living in Upper Silesia. A total of 1063 individuals (627 male and 436 female) examined for whole-blood selenium were subdivided
into six groups according to age; the youngest included adolescents (n=143) aged 10–15 yr, and the oldest were centenarians (n=132). The mean Se content was relatively low (62.5±18.4 μg/L), and it tended to be higher in men (65.9±17.2 μg/L) than in
women (57.5±18.9 μg/L). Selenium levels appeared to be age dependent, as the highest values were observed in young and middle-age
adults (21–40 yr), whereas they were significantly lower in adolescents and in the elderly. In more than 40% of apparently
healthy adults (aged 21–69 yr), the Se concentration was within the range 60–80 μg/L (i.e., below the lower limit of the nutritional
adequacy range [80 μg/L]). A significant inverse correlation between whole-blood selenium and plasma total homocysteine was
detected in a smaller population sample of middle-aged and elderly persons (n=204). 相似文献
20.
Young-Jae Kim Oyunbileg Galindev Jun Han Sei Su-Mi Bae Hosub Im Lanying Wen Young Rok Seo Woong Shick Ahn 《Biological trace element research》2009,131(2):103-109
Of trace elements in the serum of living organisms, selenium (Se) is an essential mineral and plays the role of an antioxidant
as selenoproteins protecting the organism against oxidative damage induced by hydrogen peroxide, other lipid hydroperoxides,
and their derivatives. The aim of this study was to determine the mean serum Se levels in healthy Korean volunteers (50 males
and 50 females) by using an inductively coupled plasma-mass spectrometry method. The samples were collected at the Health
Promotion Centre of Kangnam St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, Kangnam District,
Seoul in accordance with procedures approved by the Institutional Review Board of the Catholic University of Korea. The mean
serum Se level in healthy subjects was 112.05 ± 30.42 μg/l. For gender, it was 120.81 ± 27.37 μg/l for females and 103.29 ± 31.05 μg/l
for males. From the study result, there was a significant difference between the mean Se concentrations of gender groups (p = 0.0035). Also, the study indicated no effect of age on Se levels (p > 0.05) in the healthy individuals. 相似文献