共查询到20条相似文献,搜索用时 140 毫秒
1.
Hossein Salehizadeh Elham Hekmatian Meisam Sadeghi Kevin Kennedy 《Journal of nanobiotechnology》2012,10(1):3
Background
Fe3O4-gold-chitosan core-shell nanostructure can be used in biotechnological and biomedical applications such as magnetic bioseparation, water and wastewater treatment, biodetection and bioimaging, drug delivery, and cancer treatment. 相似文献2.
Background
Protease activated receptors (PARs) consist of a family of four G protein-coupled receptors. Many types of cells express several PARs, whose physiological significance is mostly unknown. 相似文献3.
Semi Oh Suk Jae Kim Soo-Kyoung Ryu Gyeong-Moon Kim Chin Sang Chung Kwang Ho Lee Oh Young Bang 《BMC neurology》2011,11(1):107
Background
Atrial fibrillation (AF) is a leading cause of fatal ischemic stroke. It was recently reported that international normalized ratio (INR) levels were associated with infarct volumes. However, factors other than INR levels that affect stroke phenotypes are largely unknown. Therefore, we evaluated the determinants of stroke phenotypes (pattern and volume) among patients with AF who were not adequately anticoagulated. 相似文献4.
Background
Determination of protein-DNA complex structures with both NMR and X-ray crystallography remains challenging in many cases. High Ambiguity-Driven DOCKing (HADDOCK) is an information-driven docking program that has been used to successfully model many protein-DNA complexes. However, a protein-DNA complex model whereby the protein wraps around DNA has not been reported. Defining the ambiguous interaction restraints for the classical three-Cys2His2 zinc-finger proteins that wrap around DNA is critical because of the complicated binding geometry. In this study, we generated a Zif268-DNA complex model using three different sets of ambiguous interaction restraints (AIRs) to study the effect of the geometric distribution on the docking and used this approach to generate a newly reported Sp1-DNA complex model. 相似文献5.
Stephen O Opiyo Rosevelt L Pardy Hideaki Moriyama Etsuko N Moriyama 《BMC evolutionary biology》2010,10(1):362
Background
Lipid A is the highly immunoreactive endotoxic center of lipopolysaccharide (LPS). It anchors the LPS into the outer membrane of most Gram-negative bacteria. Lipid A can be recognized by animal cells, triggers defense-related responses, and causes Gram-negative sepsis. The biosynthesis of Kdo2-lipid A, the LPS substructure, involves with nine enzymatic steps. 相似文献6.
Huey-Ming Lo Yih-Jeng Tsai Wen-Yuan Du Chih-Jen Tsou Wen-Bin Wu 《Journal of biomedical science》2012,19(1):18
Background
Platelet-derived growth factor (PDGF) is a potent stimulator of growth and motility of vascular smooth muscle cells (VSMCs). Abnormalities of PDGF/PDGF receptor (PDGFR) are thought to contribute to vascular diseases and malignancy. We previously showed that a carotenoid, lycopene, can directly bind to PDGF and affect its related functions in VSMCs. In this study we examined the effect of the other naturally occurring carotenoid, lutein, on PDGF signaling and migration in VSMCs. 相似文献7.
Background
Ribulose-1,5-bisphosphate is the rate-limiting enzyme in photosynthesis. The catalytic large subunit of the green-algal enzyme from Chlamydomonas reinhardtii is ~90% identical to the flowering-plant sequences, although they confer diverse kinetic properties. To identify the regions that may account for species variation in kinetic properties, directed mutagenesis and chloroplast transformation were used to create four amino-acid substitutions in the carboxy terminus of the Chlamydomonas large subunit to mimic the sequence of higher-specificity plant enzymes. 相似文献8.
Background
Reactive oxygen species (ROS) were shown to mediate aberrant contractility in hypertension, yet the physiological roles of ROS in vascular smooth muscle contraction have remained elusive. This study aimed to examine whether ROS regulate α1-adrenoceptor-activated contraction by altering myosin phosphatase activities. 相似文献9.
Ken S Frahm Ole K Andersen Lars Arendt-Nielsen Carsten D Mørch 《Biomedical engineering online》2010,9(1):69
Background
CO2 lasers have been used for several decades as an experimental non-touching pain stimulator. The laser energy is absorbed by the water content in the most superficial layers of the skin. The deeper located nociceptors are activated by passive conduction of heat from superficial to deeper skin layers. 相似文献10.
Larry Bredeson Raul Quiceno-Gonzalez Xavier Riera-Palou Andrew Harrison 《The International Journal of Life Cycle Assessment》2010,15(8):817-826
Background and scope
Attempts to develop adequate allocation methods for CO2 emissions from petroleum products have been reported in the literature. The common features in those studies are the use of energy, mass, and/or market prices as parameters to allocate the emissions to individual products. The crude barrel is changing, as are refinery complexities and the severity of conversion to gasoline or diesel leading to changes in the emissions intensity of refining. This paper estimates the consequences for CO2 emissions at refineries of allowing these parameters to vary. 相似文献11.
Nadia Zayed Xinfang Li Nadir Chabane Mohamed Benderdour Johanne Martel-Pelletier Jean-Pierre Pelletier Nicolas Duval Hassan Fahmi 《Arthritis research & therapy》2008,10(6):R146
Introduction
Prostaglandin D synthase (PGDS) is responsible for the biosynthesis of PGD and J series, which have been shown to exhibit anti-inflammatory and anticatabolic effects. Two isoforms have been identified: hematopoietic- and lipocalin-type PGDS (H-PGDS and L-PGDS, respectively). The aims of this study were to investigate the expressions of H-PGDS and L-PGDS in cartilage from healthy donors and from patients with osteoarthritis (OA) and to characterize their regulation by interleukin-1-beta (IL-1β) in cultured OA chondrocytes. 相似文献12.
Vincent J Lynch 《BMC evolutionary biology》2007,7(1):2
Background
Gene duplication followed by functional divergence has long been hypothesized to be the main source of molecular novelty. Convincing examples of neofunctionalization, however, remain rare. Snake venom phospholipase A2 genes are members of large multigene families with many diverse functions, thus they are excellent models to study the emergence of novel functions after gene duplications. 相似文献13.
Mattias Norrby Mads T Madsen Charlotte Borg Alexandersen Hans Kindahl Andrzej Madej 《Acta veterinaria Scandinavica》2007,49(1):36
Background
The aims of the present work was to study whether there are any relationships between cortisol and PG-metabolite in mated sows or inseminated with the intrauterine technique and compare these to changes occurring in conventionally inseminated sow. 相似文献14.
Varani K Padovan M Vincenzi F Targa M Trotta F Govoni M Borea PA 《Arthritis research & therapy》2011,13(6):R197
Introduction
The reduction of the inflammatory status represents one of the most important targets in rheumatoid arthritis (RA). A central role of A2A and A3 adenosine receptors (ARs) in mechanisms of inflammation has been reported in different pathologies. The primary aim of this study was to investigate the A2A and A3ARs and their involvement in RA progression measured by Disease Activity Score in 28 or 44 joints (DAS28 or DAS). 相似文献15.
Ashwin Murugappan Chockalingam Heman Kumar Ramiya Ramesh Babu Raghuraman Chittor Jai Prakash Tiwari 《Journal of nanobiotechnology》2010,8(1):30
Background
Multifunctional magnetic nanoparticles are important class of materials in the field of nanobiotechnology, as it is an emerging area of research for material science and molecular biology researchers. One of the various methods to obtain multifunctional nanomaterials, molecular functionalization by attaching organic functional groups to nanomagnetic materials is an important technique. Recently, functionalized magnetic nanoparticles have been demonstrated to be useful in isolation/detection of dangerous pathogens (bacteria/viruses) for human life. Iron (Fe) based material especially FePt is used in the isolation of ultralow concentrations (< 102 cfu/ml) of bacteria in less time and it has been demonstrated that van-FePt may be used as an alternative fast detection technique with respect to conventional polymerase chain reaction (PCR) method. However, still further improved demonstrations are necessary with interest to biocompatibility and green chemistry. Herein, we report the synthesis of Fe3O4 nanoparticles by template medication and its application for the detection/isolation of S. aureus bacteria. 相似文献16.
Gerd P Bienert Michael Thorsen Manuela D Schüssler Henrik R Nilsson Annemarie Wagner Markus J Tamás Thomas P Jahn 《BMC biology》2008,6(1):26
Background
Arsenic is a toxic and highly abundant metalloid that endangers human health through drinking water and the food chain. The most common forms of arsenic in the environment are arsenate (As(V)) and arsenite (As(III)). As(V) is a non-functional phosphate analog that enters the food chain via plant phosphate transporters. Inside cells, As(V) becomes reduced to As(III) for subsequent extrusion or compartmentation. Although much is known about As(III) transport and handling in microbes and mammals, the transport systems for As(III) have not yet been characterized in plants. 相似文献17.
Background
Polyamines and ornithine decarboxylase (ODC) are essential for cell proliferation. DL-α-difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, induces G1 arrest through dephosphorylation of retinoblastoma protein (pRb). The effect of DFMO on cell growth of pRb deficient cells is not known. We examined the effects of DFMO on pRb deficient human retinoblastoma Y79 cell proliferation and its molecular mechanism. 相似文献18.
Yoshinori Funakami Eiji Itoh Taeko Hata Tetsuyuki Wada Seiji Ichida 《BioPsychoSocial medicine》2010,4(1):13
Background
Specific alternation of rhythm in temperature (SART)-stressed rats, an animal model of autonomic imbalance, exhibit low blood pressure and tachycardia during consciousness and under anesthesia. In addition, these rats easily develop orthostatic hypotension (OH) as a response to postural manipulation. Hence, we studied the influence of the adrenalin α1-receptor agonist phenylephrine on stress-induced OH in SART-stressed rats and unstressed rats. 相似文献19.
Jennifer M Reynolds Kamal El Bissati Jens Brandenburg Arthur Günzl Choukri Ben Mamoun 《BMC clinical pharmacology》2007,7(1):13