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1.
Widespread use of metals in industrial activities has enhanced the occupational exposure to toxic metals as well as the health risks of metal hazards to humans. Elemental analysis in human tissues is the most common application of biological monitoring for screening, diagnosis and assessment of such exposures and risk. Among various biopsy materials, blood, hair, nail, teeth and body fluids may be used as bioindicators for this purpose. The present paper deals with the determination of Pb, Cr, Ni, Mn, Fe, Cu and Zn elemental concentration in workers exposed to these metals at workplace by atomic absorption spectrophotometry, with adequate quality control measures using hair as biopsy material. The study group includes the male workers such as welders, foundry man, fitter, hammer man, machine man, cupola man etc., besides office workers of locomotive workshop in Ajmer and surrounding areas exposed to different metals. Age and sex matched controls of persons working in the same area of work in offices etc. and not exposed to metal pollution were selected for valid comparison. It is proposed to validate the use of hair as a biological marker for assessing metal body burden of workers. In our study significant correlations have been found between skin disease and Cr, Mn, Fe, Cu; chest pain and Pb; hypertension and Cu, Mn; mental stress and Mn, Ni, Cu, Zn; liver problem and Ni; indigestion and Cr; Ni, diabetes and Cr, Mn, Ni; tuberculosis and Zn; breathing trouble and Cr, Mn, Fe, Ni, Zn. The advantages of choosing hair as a biopsy material are also given. 相似文献
2.
The concentrations of Cd, Cr, Cu, Mn, Ni, Pb, and Zn were estimated in hair and nails of urban residents of New Delhi. Particularly, hair levels of Cu and Mn in hypertensive males, Cr and Zn in hypertensive females, and Zn in CHD and diabetic females, and nail levels of Zn in CHD and hypertensive females were significantly lower than controls. Thus, it is observed that there exists some positive correlation between element levels in hair and nails and CHD, hypertension, and diabetes of these subjects. 相似文献
3.
The relationships between metal contents in soil, road dust, and rice, and in human hair from a rural area of China were observed for Cr, Cu, Mn, Ni, Pb, and Zn. The results showed that the mean concentrations of Mn in human hair were higher than the highest reference value. The concentrations of Cr, Cu, Ni, and Zn in soil and road dust were usually higher than their background values. The enrichment factors indicated that the determined metals in soil and road dust were usually derived from natural sources. Chromium, Pb, and Zn in soils and road dusts from several sites were slightly influenced by anthropogenic sources. The regression analyses showed that positive relationships usually exist between the concentrations of the determined metals in rice and in human hair as well as in soil and in human hair. However, relationships between metal concentrations in road dust and in human hair were less obvious. The study demonstrated that human hair was an applicable biomonitor of metal concentrations in rice, soil, and road dust from a rural area in China. Metal concentrations in local human hair could be used to predict contamination levels of metals in rice and soil. 相似文献
4.
Sehrish Talpur Hassan I. Afridi Tasneem G. Kazi Farah Naz Talpur 《Biological trace element research》2018,182(2):209-216
There have been few investigations of trace elements in the urine and hair of populations exposed to high levels of arsenic (As) in drinking water. Therefore, concentrations of selected metals in urine and hair samples from a population in a study area where arsenism was endemic and a control area were determined. It was found that the median concentrations of barium (Ba), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), zinc (Zn), and As in the urine samples from the population in the study area were 3.87, 0.47, 0.50, 61.84, 26.82, 1.33, 128.45, 7.05, 1.10, 233.75, and 339.63 μg/L, respectively. The corresponding values in the urine samples from a population in the control area were 29.08, 0.19, 0.21, 27.77, 10.32, 4.61, 14.01, 2.19, 3.90, 113.92, and 20.28 μg/L, respectively. In the study area, Ba, Cd, Co, Cr, Cu, Mo, Ni, Pb, and Zn excreted in the urine were likely to be mainly derived from drinking water with high levels of arsenic. The median concentrations of Ba, Cd, Co, Cr, Cu, Mn, Mo, Ni, Pb, Zn, and As in the hair samples from the study area were 4.16, 0.03, 0.09, 1.09, 6.54, 1.97, 0.06, 0.53, 1.64, 144.28, and 1.67 mg/kg, respectively. The corresponding values from the control area were 4.76, 0.03, 0.02, 1.41, 8.31, 1.34, 0.07, 0.39, 0.86, 154.58, and 0.29 mg/kg, respectively. Significant positive correlations were observed between As and Ba, Cd, Co, Cr, Cu, Mo, Ni, Pb, and Zn in the urine in the study area. However, As was not positively associated with these metals in the hair samples. Exposure to high levels of As in drinking water increased the accumulation of Ba and Mn in the hair and the excretion of Cd, Cu, and Mo in the urine in the study area. The population in the study area might experience Cu and Mo deficiencies for an increasing excretion of Cu and Mo. 相似文献
5.
Lung cancer is seriously threatening human health and exposure to trace metals is the most important aetiology for lung cancer. Selected essential/toxic metals (Ca, Mg, Na, K, Fe, Zn, Cu, Sr, Li, Co, Mn, Ni, Cr, Cd and Pb) are measured in the scalp hair and nails of lung cancer patients and controls by atomic absorption spectrophotometric method employing nitric acid-perchloric acid-based wet digestion. Average concentrations of Pb, Cd, Mn, Co and Cu are found to be significantly higher (p?<?0.05) in the scalp hair and nails of lung cancer patients compared with the controls, however, appreciably higher concentrations of Zn, Ca, Na, Mg and Cr are noted in the scalp hair of the controls. Most of the metal levels reveal higher dispersion and asymmetry in the scalp hair/nails of the patients compared with the controls. Average metal levels are also compared to investigate probable differences based on sex, abode, food and smoking habits. The correlation study shows significantly diverse mutual variations of the metals in the scalp hair and nails of the patients and controls. Considerable variations in the metal levels are also noted for various stages and types of lung cancer (adenocarcinoma, squamous cell carcinoma, large cell carcinoma and small cell lung cancer). Multivariate apportionment of the metals in the scalp hair and nails of the patients and controls are also significantly diverse. The study reveals considerably divergent variations in the metal levels in lung cancer patients in comparison with healthy subjects. 相似文献
6.
Metal determination in human tissues is the most common application of biological monitoring for screening, diagnosis and
assessment of metal exposures and their risks. Various biopsy-materials may be used. This paper deals with the quantitative
determination of Cd, Pb, Cr, Mn, Fe, Ni, Cu, and Zn concentrations in nails of male subjects exposed to these metals alongwith
their respective controls, while working in locomotive, carriage and roadways workshops, and lead battery factories. The levels
of Cd, Pb, Cr, Mn, Fe, Ni, Cu and Zn in fingernails, assayed by atomic absorption spectrophotometry, were compared with their
respective controls by student ‘t’ test. All the obtained values were correlated to the personal and medical history of the
subjects under study. Significantly high levels of Cd, Pb, Cr, Fe, Ni, Cu and Zn were present in smokers, compared to nonsmokers.
The concentrations of Cd, Pb, Cr, Mn and Fe were not significantly high in vegetarian subjects. It was also observed that
there is no contribution of liquor towards nail-metal concentration. Significant correlations were observed between skin disease
and Cr, Mn, Fe, Cu; hypertension and Cd, Mn, Cu; mental stress and Cd, Pb, Mn, Ni, Cu, Zn; diabetes and Cr, Mn, Ni; chest
pain and Pb; respiratory trouble and Cr, Mn, Fe, Ni, Zn; tuberculosis and Zn; acidity and Cd; and ophthalmic problems and
Mn, Fe, Ni, and Zn 相似文献
7.
Multivariate analysis of the selected metals in the hair of cerebral palsy patients versus controls 总被引:1,自引:0,他引:1
Khalique A Shah MH Jaffar M Shaheen N Tariq SR Manzoor S 《Biological trace element research》2006,111(1-3):11-22
Seventeen metals were measured in scalp hair samples from cerebral palsy patients (CPPs) and controls. Samples were collected
from 95 CPPs and 93 controls. The nitric acid-perchloric acid wet digestion procedure was used for quantification of the selected
metals by flame atomic absorption spectrophotometry. The concentrations of Ag, Ca, Cd, Co, Cr, Li, and Mg were significantly
higher and those of Cu, Fe, K, Mn, Na, Ni, Pb, and Sb were lower in the hair of CPPs compared with controls. A strong positive
correlation was found between Ca and Mg in the hair of controls but not in that of CPPs. Antimony was found significantly
negative in terms of its correlation with Co and Cu in CPPs group but not in the controls. Principal component analysis (PCA)
of the data extracted seven factors for CPPs and six factors for controls. Cluster analysis (CA) was also used to support
the PCA results. The study evidenced some specific source of Mg and Sb in the hair of CPPs. 相似文献
8.
Samples of hair and nails collected from the residents of Wazirpur, a village adjacent to New Delhi, were analyzed for Cd, Cr, Cu, Mn, Ni, Pb, and Zn, and correlated with the residents' rural and urban places of occupations. It was observed that Pb and Cd hair levels of males working in rural areas were lower than in male businessmen and officers working in an urban area of New Delhi, thereby showing the different levels of elements exposure of the rural subjects. Such differences in the hair levels of elements were not observed among female subjects. The tobacco smoking habits of male and female rural subjects using hookah were associated with increased Cd levels in hair and nails. 相似文献
9.
Trace element content in hair is affected by the age of the donor. Hair samples of subjects from four counties in China where
people are known to have long lifespan (“longevity counties”) were collected and the trace element content determined. Samples
were subdivided into three age groups based on the age of the donors from whom these were taken: children (0–15 years); elderly
(80–99 years); and centenarians (≥100 years). We compared the trace element content in hair of different age groups of subjects.
Support vector machine classification results showed that a non-linear polynomial kernel function could be used to classify
the three age groups of people. Age did not have a significant effect on the content of Ca and Cd in human hair. The content
of Li, Mg, Mn, Zn, Cr, Cu, and Ni in human hair changed significantly with age. The magnitude of the age effect on trace element
content in hair was in the order Cu > Zn > Ni > Mg > Mn > Cr > Li. Cu content in hair decreased significantly with increasing
age. The hair of centenarians had higher levels of Li and Mn, and lower levels of Cr, Cu, and Ni comparing with that of the
children and elderly subjects. This could be a beneficial factor of their long lifespan. 相似文献
10.
Study of the age and sex dependence of trace elements in hair by correspondence analysis 总被引:2,自引:0,他引:2
Valerie Zakrgynska-Fontaine Jean-Christophe Doré Tiiu Ojasoo Françoise Poirier-Duchêne Claude Viel 《Biological trace element research》1998,61(2):151-168
The aim of the study was to examine the potential of multidimensional analysis, and in particular of correspondence analysis
(CA), in bringing to light the influence of sex and age on trace element (TE) concentrations in hair from an unselected French
population. Sixteen elements (S, Hg, Se, Zn, Pb, Cd, Ni, Co, Mn, Fe, Cr, Mg, Al, Ca, Cu, Ag) were assayed by inductively coupled
argon plasma (ICAP) emission specrroscopy in the scalp hair of 135 men and 346 women. In spite of the high background noise,
CA was able to reveal the differing patterns in males and females. For instance, in this population, higher relative levels
of the essential elements, Ca, Mg, Zn, and Cu, but also of Ag, characterized women’s hair, whereas higher relative levels
of the heavy metals, Fe and Pb, were associated with men’s hair. Al and Ag were unexplainedly high in the hair of the youngest
members of the population. The Cu and Co of youth seemed to give way to a predominance of Zn in maturity. The hair of individuals
in their forties tended to be richest in Ca and Mg, but these elements decreased with advancing age. Heavy metals (Hg, Pb,
Fe) accumulated with age, whereas Se, Mn, and Cr seemed independent of age. CA is manifestly a very useful tool for revealing
underlying dimensions in complex dynamic systems and unsuspected relationships among variables. Clearly, the significance
of the high Al and Ag contents in the hair of certain members of the population, especially of the very young, needs to be
investigated from both physiological and toxicological aspects. 相似文献
11.
Qaisara Pasha Salman A. Malik Nazia Shaheen Munir H. Shah 《Biological trace element research》2010,134(2):160-173
Trace elements including Al, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, Sb, Sr, and Zn were analyzed in the scalp hair
samples of women with malignant breast lesions, women with benign breast lesions, and healthy donors using atomic absorption
spectrophotometric method. In the scalp hair of malignant-tumor patients, the highest average concentration was shown by Ca
(1,187 μg/g), followed by Na (655 μg/g), Mg (478 μg/g), Zn (391 μg/g), Sr (152 μg/g), Fe (114 μg/g), and K (89.8), while in
the case of benign-tumor patients, the average estimated element levels were 1,522, 1,093, 572, 457, 217, 80.4, and 74.7 μg/g,
respectively. Most of the elements exhibited non-normal distribution evidenced by large spread, standard error, and skewness
values. Mean concentrations of Ca (634 μg/g), Zn (206 μg/g), Mg (162 μg/g), Fe (129 μg/g), and Na (82.1 μg/g) were noteworthy
in the scalp hair of healthy women. Average levels of Na, Sr, K, Cd, Co, Pb, Mg, Ca, Zn, Ni, Sb, and Mn were revealed to be
significantly higher in the hair of malignant and benign patients compared to the healthy women; however, Fe, Cu, Al, and
Cr were not significantly different in the scalp hair of the three groups. The quartile distributions of Ca, Cd, Co, Cr, K,
Mg, Mn, Na, Ni, Pb, Sb, and Sr revealed maximum spread in the scalp hair of malignant and benign groups; nevertheless, Al,
Cu, Fe, and Zn exhibited almost comparable quartile levels in the three groups. Strong correlation coefficients were found
between Fe and Cd, Al and Na, Mn and Sr, Co and Cr, Cd and Cr, Pb and K, Pb and Mn, Cu and Na, and Al and Fe in the scalp
hair of malignant-tumor patients, while Fe and K, Cd and Co, Na and Co, and Cr and Pb showed strong correlations in the scalp
hair of benign-tumor patients, both of which were significantly different compared with the healthy subjects. Multivariate
cluster analysis also revealed divergent clustering of the elements in the scalp hair of malignant and benign patients in
comparison with the healthy women. 相似文献
12.
Mari Takagi Kazuhiro Ozawa Hiroshi Yasuda Mitsuko Douke Kazunori Hashimoto Yuichi Hayashi Takashi Inuzuka Isao Hozumi 《Biological trace element research》2013,151(1):9-13
The remarkable calcification of the basal ganglia and cerebellum has been traditionally called Fahr’s disease, but this nomenclature is criticized for including heterogeneous diseases. To determine the pattern of some biological metals in the hair of patients with Fahr’s disease, we investigated the levels of 24 bioelements in the hair of 28 patients (17 males and 11 females) with Fahr’s disease and compared them with those of three age-, sex-, and living region-matched controls (84 controls in total). Interestingly, we found decreases in the levels of several bioelements [calcium (Ca), copper (Cu), iron (Fe), mercury (Hg), iodine (I), nickel (Ni), phosphate (P), lead (Pb), and selenium (Se)] in the hair of patients. This is in contrast to our previous finding of increases of Cu, Fe, zinc (Zn), and magnesium (Mg) in the cerebrospinal fluid (CSF) of patients. The decreased level of Cu in the hair was the most prominent and pathognomonic, while the increased level of Cu in the CSF had been found to be the most significant in patients. More significant correlations between two bioelements in the hair were recognized in patients than controls. Although Fahr’s disease has been considered to be a heterogenous entity, the significant tendencies of several bioelements in the hair of patients in this study suggest metabolic disorders of bioelements, especially biometals, on the background. Some transporters, especially P transporter such as PiT2, of bioelements will be involved in the different distribution of bioelements in the body of patients. 相似文献
13.
Concentrations of minor and trace elements (Mg, Ca, Fe, Ba, Cu, Zn, Cd, Ni, Al, Mn, Cr, Ti, and V) in the hair of three races of dogs (fox terrier, schnauzer, and mini schnauzer) were analyzed by the inductively coupled plasma-atomic emission spectrometry method. The influence of five washing solutions, deionized water, acetone, methanol, EDTA, and Triton X-100, on the concentrations measured in hair was investigated. Triton X-100 was found to be suitable to use for the removal of exogenous elements in multielemental hair analysis. Additionally, the results indicated that the concentration of the elements measured in the dogs' hair were similar to those reported for human hair. The relation between the element content in the dog hair and its color were similar to those found for human hair. 相似文献
14.
Asano K Suzuki K Chiba M Sera K Matsumoto T Asano R Sakai T 《Biological trace element research》2005,103(2):169-176
The influence of hair color on the trace elemental status in horse's hair has been studied. A current analytical technique
such as particle-induced X-ray emission (PIXE) used in this study has provided reliable, rapid, easy, and relatively inexpensive
diagnostic methods. Twenty-eight elements (Al, Br, Ca, Cl, Co, Cu, Cr, Fe, Ga, Hg, K, Mg, Mn, Mo, Na, Nb, Ni, P, Pb, Rb, S,
Se, Si, Sr, Ti, V, Y, and Zn) in mane hair were detected by the PIXE method. The gray hair contains significantly greter amounts
of Cu, Ti, and Zn, and lower amounts of Br, Ca, Se, and Sr than those in other colored horse hairs (p<0.05). Those results measured in the horse's hair were similar to those found in human and dog hair. When interpreting a
result, it should be kept in mind that hair color, especially gray hair, influences the concentrations of some elements in
horse hair. 相似文献
15.
Biological samples were collected simultaneously with environmental quality investigations. Studies of metal levels in biological
(hair and teeth) and environmental (soil and air) samples were performed in Zwardoń during 1991/1992. Zwardoń is a small mountain
resort village, situated on the border pass of Zwardoń, in the close proximity of the southwestern border of Poland. Heavy
metal levels in soil, air, and chemical metals forms in the soil were examined. Pearson’s product correlation in soil (for
total concentration of heavy metals and each chemical form) in hair and in teeth was calculated to investigate bioavailability
of heavy metals in human organism. We received essential correlations simultaneously between: Pb vs Mn in exchangeable form
of metal in soil, in teeth and in soil (total); Cd vs Zn and Mn vs Co in organically bound form in soil and in teeth and soil
(total); and Cu vs Zn in all investigated samples (teeth, hair, soil total, and organically bound form in soil); Mn vs Co
and Cr vs Mn in residual form in soil, in teeth, and in soil (total) and between Co vs Ni for hair, soil (total), and residual
form in soil. 相似文献
16.
Margarita G. Skalnaya Anatoly V. Skalny Andrey R. Grabeklis Eugeny P. Serebryansky Vasily A. Demidov Alexey A. Tinkov 《Biological trace element research》2018,186(1):12-20
The objective of the present study was to investigate the level of toxic and essential trace elements in hair of adult overweight and obese persons as well as its association with metabolic parameters. Hair trace element levels were assessed using inductively coupled plasma mass-spectrometry in 112 overweight and obese patients and 106 lean controls. Serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, uric acid (UA) levels, and cholinesterase (CE) and gamma-glutamyltransferase (GGT) activity were also assessed. Excessive body weight significantly affected hair trace element levels. In particular, hair Co (33%), Cu (13%), I (30%), Mg (2-fold), Mn (25%), Zn (17%), and Ni (21%) levels were lower, whereas Al (14%) and As levels were higher in comparison to those in the control group. Correlation analysis demonstrated the most significant correlations for hair Mg with body weight, BMI, systolic and diastolic blood pressure, and UA, and for hair Al with body weight, BMI, TC, glucose, TG, CE, GGT, and UA. Multiple regression analysis demonstrated that trace elements were not associated with TC and LDL-C levels neither in crude nor in adjusted models. In turn, crude and adjusted models accounted for 25 and 43% of serum TG variance. The most significant associations were observed for hair Al, Fe, Si, and V in adjusted model. The obtained data demonstrate that obesity-related metabolic disorders may be at least partially mediated by altered trace element and mineral levels. 相似文献
17.
V. Ya. Kavun 《Russian Journal of Marine Biology》2008,34(1):64-72
The concentrations of Fe, Zn, Cu, Cd, Mn, Pb, and Ni were determined in the hepatopancreas, muscle tissue, and carapace of the grass shrimp Pandalus kessleri from the coastal waters of the Lesser Kurilskaya Ridge. Sex reversal of the grass shrimp, which is a proterandrous hermaphrodite, had a marked influence on the concentrations of such metals as Fe, Cu, Cd, and Mn. The levels of Cd in the hepatopancreas of grass shrimp exceeded maximum permissible concentrations for seafood at all the stations studied. The main factors determining the metal levels in P. kessleri from the investigated locations are discussed. 相似文献
18.
Dallas M. Cowan Qiyuan Fan Yan Zou Xiujuan Shi Jian Chen Michael Aschner 《Biomarkers》2013,18(1):3-16
Unexposed control subjects (n = 106), power distributing and office workers (n = 122), and manganese (Mn)-exposed ferroalloy smelter workers (n = 95) were recruited to the control, low and high groups, respectively. Mn concentrations in saliva, plasma, erythrocytes, urine and hair were significantly higher in both exposure groups than in the controls. The Fe concentration in plasma and erythrocytes, however, was significantly lower in Mn-exposed workers than in controls. The airborne Mn levels were significantly associated with Mn/Fe ratio (MIR) of erythrocytes (eMIR) (r = 0.77, p < 0.01) and plasma (pMIR) (r = 0.70, p < 0.01). The results suggest that the MIR may serve as a useful biomarker to distinguish Mn-exposed workers from the unexposed, control population. 相似文献
19.
川金丝猴体毛微量元素的分析 总被引:1,自引:0,他引:1
应用等离子发射光谱法分析了秦岭产川金丝猴体毛中Na、K、Ca、Mg、Zn、Cd、Co、Cu、Ni、Sr、Li、Fe、Al、Mn、B、P16种微量元素的含量,发现除Zn与Mn有显著的性别差异外,余者无显著的性别差异,一般雄性稍高于雌性。与四川产川金丝猴体毛中的Zn、Ca、Cu、Fe含量比较,两地区样本均有极显著的差异。 相似文献
20.
Although the connection between aluminum intoxication and dialysis dementia was identified in the 1980s, understanding of
trace element imbalances in hemodialysis patients is as yet incomplete. Recent application of newer inductively coupled plasma-mass
spectrometry (ICP/MS) techniques has resulted in renewed study of this population. We used ICP/MS to evaluate serum concentrations
of Cu, Se, Zn, Mn, and Ni in a relatively large population of hemodialysis patients compared with healthy age-matched controls.
Comparison were also done by duration of hemodialysis treatment to see whether length of treatment correlates with severity
of imbalance. Patients had significantly lower concentrations of the three elements Se, Zn, and Mn. Patients had significantly
higher concentrations of Ni, and there was a positive correlation between duration and severity of imbalance for this one
element. There was no difference in Cu concentrations between patients and controls. Our findings confirm relative Ni excess
and deficiencies of Se, Zn, and Mn in hemodialysis patients, documenting the value of ICP/MS in research work on trace element
imbalances as well as clinical monitoring of individual patients. 相似文献