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1.
《Molecular & cellular proteomics : MCP》2019,18(6):1157-1170
Highlights
- •Auxin responsive proteins in Arabidopsis roots were identified from 3,514 detected proteins.
- •All six auxin receptors are stable in response to hormone via novel MRM assays.
- •The >100 differentially expressed proteins exhibit dynamic and transient responses to auxin.
- •Phenotypic screening of the top responsive proteins uncovered several novel root mutants.
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《Molecular & cellular proteomics : MCP》2019,18(6):1085-1095
Highlights
- •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
- •The mitochondrial proteins processing system is robust under subtoxic conditions.
- •Rapamycin and zinc perturb the mitochondrial proteins processing system.
- •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
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《Molecular & cellular proteomics : MCP》2018,17(11):2146-2163
Highlights
- •Construction of threespine stickleback gill assay library using DDA proteomics
- •Population-specific gill proteome signatures of four ecotypes identified by DIA
- •HSP47 and extracellular matrix proteins highly elevated in warm-adapted sticklebacks
- •Inflammasome and proteolytic proteins highly elevated in freshwater sticklebacks
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《Molecular & cellular proteomics : MCP》2018,17(12):2412-2433
Highlights
- •Proteogenomics and secretome comparison of human and zoonotic Staphylococcus aureus lineages.
- •869 secreted proteins identified in eight S. aureus isolates of CC8, CC22 and CC398.
- •CC398 lower secretion of surface proteins and higher secretion of hemolysins and exoenzymes.
- •Regulatory differences in the secretomes could be linked to lower SigB activity in CC398.
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《Molecular & cellular proteomics : MCP》2019,18(12):2359-2372
Highlights
- •Nonenzymatically Ksu proteins shown different pattern from native cell Ksu proteins.
- •Motif preference of Ksu proteins was associated with different biological processes.
- •Up to 67 developing rice seeds proteins contain PTMs of Kac, Ksu, Kcr, Kmal, and Khib.
- •Some lysine residues of the key pathway enzymes are modified by succinylation.
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《Molecular & cellular proteomics : MCP》2019,18(1):41-50
Highlights
- •Proteome of mature boar spermatozoa from cauda epididymal and ejaculated sources were analyzed by iTRAQ-based LC-MS/MS.
- •1,723 sperm proteins identified (974 of Sus scrofa taxonomy).
- •1,602 sperm proteins quantified (960 of Sus scrofa taxonomy).
- •32 Sus scrofa sperm proteins were differentially expressed among sperm sources.
- •The proteome of boar spermatozoa is remodelled during ejaculation.
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《Molecular & cellular proteomics : MCP》2019,18(9):1796-1806
Highlights
- •iTRAQ-based analysis of saliva samples from oral cancer patients.
- •Proteome profiling of saliva samples from patients with oral premalignant lesions.
- •Verification of salivary biomarker candidates with MRM-MS and immunoassays.
- •Identification of salivary proteins as potential biomarkers of oral cancer.
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《Molecular & cellular proteomics : MCP》2019,18(11):2244-2261
Highlights
- •Proteomic analysis of brain and cerebrospinal fluid from mouse NCL models.
- •Disease-associated changes in lysosomal proteins and markers of neuroinflammation.
- •Biomarker candidates identified for further evaluation.
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《Molecular & cellular proteomics : MCP》2019,18(6):1110-1122
Highlights
- •Comprehensive analysis of inter-individual variation of normal urinary proteome.
- •Significant gender differences were observed.
- •Proteins increased in female urine are enriched in immunological pathways.
- •Estimated reference intervals of proteins as the baseline for biomarker discovery.
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《Molecular & cellular proteomics : MCP》2019,18(5):936-953
Highlights
- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
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《Molecular & cellular proteomics : MCP》2019,18(7):1285-1306
Highlights
- •Identification of previously undetected chloroplast envelope proteins.
- •Up to date manual annotation of genuine (or shared) envelope components.
- •New hypotheses for localizations, functions, interactions among cell compartments.
- •A new resource of significant value to the broader plant science community.
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《Molecular & cellular proteomics : MCP》2019,18(11):2285-2297
Highlights
- •BioID with Golgi fractions identified C10orf76 as proximal to GBF1.
- •Tagged C10orf76 overlaps with Golgi markers.
- •C10orf76 binds GBF1 and exchanges rapidly between free and bound forms.
- •C10orf76 is essential for maintenance of the Golgi and for secretion.
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《Molecular & cellular proteomics : MCP》2018,17(11):2242-2255
Highlights
- •BioID and IP-MS were conducted to generate a global ZIKV-host protein interactome
- •Interactome consists of >3000 high confidence ZIKV-host protein interactions
- •Data mining indicates that ZIKV proteins interact with multiple host cell organelles
- •An important role for peroxisomes in ZIKV infection is uncovered
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Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
Highlights
- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
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《Molecular & cellular proteomics : MCP》2019,18(7):1345-1362
Highlights
- •Plant mitoribosomes contain several pentatricopeptide repeat proteins.
- •The small mitoribosomal subunit is of an exceptionally large size.
- •Protein units not directly related to translation may be attached to plant mitoribosomes to confer additional functions to these molecular machines.
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《Molecular & cellular proteomics : MCP》2019,18(12):2516-2523
Highlights
- •Open source software for comprehensive HDX-MS data analysis.
- •Automatic back-exchange correction options.
- •Rigorous statistical analysis of the significance of uptake differences.
- •High quality visualization tools.