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1.
《Molecular & cellular proteomics : MCP》2019,18(5):818-836
Highlights
- •Kallikrein-related peptidase 7 is over expressed in ovarian cancer.
- •Quantitative PROTOMAP and TAILS approaches identified putative substrates of KLK7.
- •Pro-MMP10 is activated by KLK7.
- •KLK7 cleaves thrombospondin 1 and IGFBP6 in vitro.
2.
《Molecular & cellular proteomics : MCP》2019,18(6):1171-1182
Highlights
- •First report on the quantitative proteomic profiling of Drosophila lymph glands.
- •Comparative proteomic analysis under conditions of perturbed blood cell homeostasis.
- •Resource for identifying new regulators of insect and vertebrate hematopoiesis.
3.
《Molecular & cellular proteomics : MCP》2019,18(6):1210-1226
Highlights
- •Quantitative global proteome, acetylome and succinylome of phytoplasma-infected Paulownia tomentosa seedlings.
- •Acetylation may be more important than succinylation in response to phytoplasma infection.
- •Acetylation modified the activities of POR and RuBisCO.
- •Possible model to elucidate the molecular mechanism responses to PaWB from proteome and PTMs.
4.
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
Highlights
- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
5.
《Molecular & cellular proteomics : MCP》2019,18(8):1556-1571
Highlights
- •Functional role of a yet uncharacterized receptor kinase QSK1.
- •Activation model for SIRK1 receptor kinase in a heteromer with QSK1.
- •Role of QSK1 in substrate recruitment and stabilization of the complex.
6.
《Molecular & cellular proteomics : MCP》2019,18(8):1479-1490
Highlights
- •Frequent genetic polymorphism affects the glycosylation pattern of fetuin.
- •Personalized in-depth proteoform profiling of fetuin purified from 20 donors.
- •Classification of serum donors into three different genotypes.
- •Septic patients show increased level of fucosylation at N-glycolation site N176.
7.
《Molecular & cellular proteomics : MCP》2019,18(6):1157-1170
Highlights
- •Auxin responsive proteins in Arabidopsis roots were identified from 3,514 detected proteins.
- •All six auxin receptors are stable in response to hormone via novel MRM assays.
- •The >100 differentially expressed proteins exhibit dynamic and transient responses to auxin.
- •Phenotypic screening of the top responsive proteins uncovered several novel root mutants.
8.
《Molecular & cellular proteomics : MCP》2019,18(7):1285-1306
Highlights
- •Identification of previously undetected chloroplast envelope proteins.
- •Up to date manual annotation of genuine (or shared) envelope components.
- •New hypotheses for localizations, functions, interactions among cell compartments.
- •A new resource of significant value to the broader plant science community.
9.
《Molecular & cellular proteomics : MCP》2019,18(6):1183-1196
Highlights
- •Atlantic salmon O-glycome expanded to 169 structures in three epithelia.
- •Low interindividual variation amongst all populations and geographical regions.
- •Small variations in glycosylation between geographical locations and fish size.
- •Prominent fucosylation in gastrointestinal mucins from Tasmanian fish.
10.
《Molecular & cellular proteomics : MCP》2019,18(7):1437-1453
Highlights
- •mRNA-seq, miRNA-seq, proteomes of P. fulvidraco, P. vachelli, hybrid Huangyou-1.
- •Predicted miRNA-mRNA-protein pairs were found and validated by qRT-PCR and PRM.
- •Immune, metabolism, digestion, absorption, proliferation, development generate heterosis.
- •High parental gene/protein with low parental miRNAs inherit from the mother or father.
11.
《Molecular & cellular proteomics : MCP》2019,18(10):2089-2098
Highlights
- •Cathepsin-L is introduced as a novel protease for HX-MS studies.
- •Cathepsin-L improves resolution of traditionally challenging histone tails.
- •Cathepsin-L can be readily combined with pepsin for improved protein coverage.
- •In-solution dynamics of the H3.1 and H4 monomers reveal extensive EX1 kinetics.
12.
《Molecular & cellular proteomics : MCP》2019,18(6):1110-1122
Highlights
- •Comprehensive analysis of inter-individual variation of normal urinary proteome.
- •Significant gender differences were observed.
- •Proteins increased in female urine are enriched in immunological pathways.
- •Estimated reference intervals of proteins as the baseline for biomarker discovery.
13.
《Molecular & cellular proteomics : MCP》2019,18(8):1526-1542
Highlights
- •Definition of early systemin-responsive phosphorylation time course.
- •Reconstruction of kinase-substrate relationships from phosphorylation time profiles.
- •Phosphatase PLL5 rapidly dephosphorylated H+-ATPase LHA1 inducing alkalinization of the medium.
- •MAP-Kinase MPK2 re-phosphorylated LHA1 after 15 minutes.
14.
《Molecular & cellular proteomics : MCP》2019,18(4):686-703
Highlights
- •nLC-MS/MS method to analyze immunoglobulin (Ig) N-glycopeptides from human serum.
- •Multi-isotype, site-specific characterization of immunoglobulin N-glycosylation.
- •IgA2 sequence and glycosylation-site variant analyses.
- •Platform to define disease-specific N-glycan signatures for different Ig isotypes.
15.
《Molecular & cellular proteomics : MCP》2019,18(5):837-853
Highlights
- •Production of sera with different levels of protection against rodent Plasmodium.
- •Generation of immunomic and proteomic data sets enriched in protective antigens.
- •Prediction of the most likely protective antigens using a weighted scoring system.
16.
17.
《Molecular & cellular proteomics : MCP》2019,18(6):1085-1095
Highlights
- •Rapamycin and zinc induce moderate but significant mitochondrial proteome changes.
- •The mitochondrial proteins processing system is robust under subtoxic conditions.
- •Rapamycin and zinc perturb the mitochondrial proteins processing system.
- •Rapamycin and zinc perturb the mitochondrial proteins homeostasis.
18.
19.
《Molecular & cellular proteomics : MCP》2019,18(5):854-864
Highlights
- •Zero-length chemical cross-linking of APOA1 peptides in HDL.
- •Cross-links match antiparallel isomers of APOA dimers in molecular modeling.
- •Identical MS/MS spectra of native and synthetic cross-linked peptides.
- •First biochemical evidence of LL5/5 and LL5/4 isomers in human HDL.
20.
《Molecular & cellular proteomics : MCP》2019,18(4):657-668
Highlights
- •Global proteomic remodeling alters antibiotic susceptibility in K. pneumoniae.
- •Drug specific transport, sugar utilization, central metabolism, capsule synthesis.
- •Common pathways of reactive oxygen scavenging, turnover of misfolded proteins.
- •Integrated adjustments and unique drug-specific features for drug combinations.