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Systemic silencing signal(s) 总被引:18,自引:0,他引:18
Grafting experiments have revealed that transgenic plants that undergo co-suppression of homologous transgenes and endogenous genes or PTGS of exogenous transgenes produce a sequence-specific systemic silencing signal that is able to propagate from cell to cell and at long distance. Similarly, infection of transgenic plants by viruses that carry (part of) a transgene sequence results in global silencing (VIGS) of the integrated transgenes although viral infection is localized. Systemic PTGS and VIGS strongly resemble recovery from virus infection in non-transgenic plants, leading to protection against secondary infection in newly emerging leaves and PTGS of transiently expressed homologous transgenes. The sequence-specific PTGS signal is probably a transgene product (for example, aberrant RNA) or a secondary product (for example, RNA molecules produced by an RNA-dependent RNA polymerase with transgene RNA as a matrix) that mimics the type of viral RNA that is targeted for degradation by cellular defence. Whether some particular cases of transgene TGS could also rely on the production of such a mobile molecule is discussed. 相似文献
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Post-transcriptional gene silencing in cultured rice cells 总被引:5,自引:0,他引:5
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Stable high-level transgene expression in Arabidopsis thaliana using gene silencing mutants and matrix attachment regions 总被引:7,自引:0,他引:7
Butaye KM Goderis IJ Wouters PF Pues JM Delauré SL Broekaert WF Depicker A Cammue BP De Bolle MF 《The Plant journal : for cell and molecular biology》2004,39(3):440-449
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Mallory AC Parks G Endres MW Baulcombe D Bowman LH Pruss GJ Vance VB 《Nature biotechnology》2002,20(6):622-625
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Transcriptional and posttranscriptional gene silencing are mechanistically related 总被引:30,自引:0,他引:30
Sijen T Vijn I Rebocho A van Blokland R Roelofs D Mol JN Kooter JM 《Current biology : CB》2001,11(6):436-440
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