Antibody Engineering & Therapeutics 2015: The Antibody Society's annual meeting December 7–10, 2015, San Diego,CA

Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society, will be held in San Diego, CA in early December 2015. In this meeting preview, the chairs provide their thoughts on the importance of their session topics, which include antibody effector functions, reproducibility of research and diagnostic antibodies, new developments in antibody-drug conjugates (ADCs), preclinical and clinical ADC data, new technologies and applications for bispecific antibodies, antibody therapeutics for non-cancer and orphan indications, antibodies to harness the cellular immune system, overcoming resistance to clinical immunotherapy, and building comprehensive IGVH-gene repertoires through discovering, confirming and cataloging new germline IGVH genes. The Antibody Society's special session will focus on “Antibodies to watch” in 2016, which are a subset of the nearly 50 antibodies currently in Phase 3 clinical studies. Featuring over 100 speakers in total, the meeting will commence with keynote presentations by Erica Ollmann Saphire (The Scripps Research Institute), Wayne A. Marasco (Dana-Farber Cancer Institute/Harvard Medical School), Joe W. Gray (Oregon Health & Science University), and Anna M. Wu (University of California Los Angeles), and it will conclude with workshops on the promise and challenges of using next-generation sequencing for antibody discovery and engineering from synthetic and in vivo libraries and on computational antibody design.     

Antibody Engineering & Therapeutics 2015: The Antibody Society's annual meeting December 7–10, 2015, San Diego,CA

Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society, will be held in San Diego, CA in early December 2015. In this meeting preview, the chairs provide their thoughts on the importance of their session topics, which include antibody effector functions, reproducibility of research and diagnostic antibodies, new developments in antibody-drug conjugates (ADCs), preclinical and clinical ADC data, new technologies and applications for bispecific antibodies, antibody therapeutics for non-cancer and orphan indications, antibodies to harness the cellular immune system, overcoming resistance to clinical immunotherapy, and building comprehensive IGVH-gene repertoires through discovering, confirming and cataloging new germline IGVH genes. The Antibody Society''s special session will focus on “Antibodies to watch” in 2016, which are a subset of the nearly 50 antibodies currently in Phase 3 clinical studies. Featuring over 100 speakers in total, the meeting will commence with keynote presentations by Erica Ollmann Saphire (The Scripps Research Institute), Wayne A. Marasco (Dana-Farber Cancer Institute/Harvard Medical School), Joe W. Gray (Oregon Health & Science University), and Anna M. Wu (University of California Los Angeles), and it will conclude with workshops on the promise and challenges of using next-generation sequencing for antibody discovery and engineering from synthetic and in vivo libraries and on computational antibody design.     

专注目标,锐意进取——帝斯曼发布2015战略目标

一场百年未遇的金融危机让全球经济蒙上一层阴影.然而作为始终关注并致力于经济效益、环境质量和社会责任三方面和谐发展的帝斯曼公司在这场鏖战中不负所望,实现了"愿景2010"的绝大部分战略目标,成功转型成为生命科学和材料科学的专业公司.并于2010年底公布了今后五年的新战略--"专注目标,锐意进取".     

中东以外地区最大一次中东呼吸综合征暴发,韩国,2015

2015年5月11日至12月23日在韩国由一名从中东返回的旅行者引发了中东呼吸综合征暴发。186人发病,38人死亡。年龄偏大和存在基础性疾患是病人死亡的危险因素。这是中东以外地区最大一次中东呼吸综合征暴发,具有以下流行病学特征:(1)医院感染是最重要的暴发原因,但大量受攻击的是非护理人员(154/184);(2)家庭感染少见,无社区感染,传播呈多中心性;(3)呈现多代型继发感染病例,第1代感染者26例,第2代120例,第3代22例,第4代5例;(4)传播方式主要是微滴传播,直接接触传播仅约10%,大多数感染发生于和病人相处同一护理环境,最大可能是污染物传播。此外,中国发现由韩国输入的一例中东呼吸综合征病例。韩国暴发期间的MERS-COV有较高的遗传变异性和突变率。     

Antibody engineering & therapeutics,the annual meeting of the antibody society December 7–10, 2015, San Diego,CA, USA

The 26th Antibody Engineering & Therapeutics meeting, the annual meeting of The Antibody Society united over 800 participants from all over the world in San Diego from 6–10 December 2015. The latest innovations and advances in antibody research and development were discussed, covering a myriad of antibody-related topics by more than 100 speakers, who were carefully selected by The Antibody Society. As a prelude, attendees could join the pre-conference training course focusing, among others, on the engineering and enhancement of antibodies and antibody-like scaffolds, bispecific antibody engineering and adaptation to generate chimeric antigen receptor constructs. The main event covered 4 d of scientific sessions that included antibody effector functions, reproducibility of research and diagnostic antibodies, new developments in antibody-drug conjugates (ADCs), preclinical and clinical ADC data, new technologies and applications for bispecific antibodies, antibody therapeutics for non-cancer and orphan indications, antibodies to harness the cellular immune system, building comprehensive IgVH-gene repertoires through discovering, confirming and cataloging new germline IgVH genes, and overcoming resistance to clinical immunotherapy. The Antibody Society's special session focused on “Antibodies to watch” in 2016. Another special session put the spotlight on the limitations of the new definitions for the assignment of antibody international nonproprietary names introduced by the World Health Organization. The convention concluded with workshops on computational antibody design and on the promise and challenges of using next-generation sequencing for antibody discovery and engineering from synthetic and in vivo libraries.     

2015年诺贝尔化学奖

2015年诺贝尔化学奖被授予托马斯·林达尔、保罗·莫德里奇和阿齐兹·桑贾尔,以表彰他们在分子水平上解析出细胞如何修复受损DNA及保护遗传信息。他们的工作为活体细胞是如何工作提供了基础的认知,以及例如,如何用于新癌症疗法的开发。     

Trends in cancer incidence in the Republic of Mauritius, 1991–2015

IntroductionMauritius, a small state, is among the few African countries where cancer registration is population based and nationwide. We reported trends in cancer incidence for twenty five years as well as the mortality to incidence ratio (MIR) as main quality indicator of the Mauritius National Cancer Registry (MNCR).Materials and methodsWe calculated age standardised incidence rates (ASRs) of cancers by sex and by 5 year age group for five successive year periods from 1991 to 2015. The average annual percentage change (AAPC) were determined by sex and cancer sites. MIRs were compared for the period 2001–2004 and 2012–2015.ResultsIn males, the most common cancer sites (in terms of ASRs per 100,000) were those of the colon-rectum (17.0), prostate (16.5), trachea-bronchus-lung (13.0), stomach (8.4) and lip-oral cavity-pharynx (7.7). The AAPC were +3.9%, +4.2%, +0.5%, -0.1% and -1.3% respectively. In females, the most frequent sites were breast (53.7), colon-rectum (13.2), cervix uteri (11.2), corpus uteri (7.7) and ovary (5.7). The AAPC were +3.4%, +4.4%, -2%, +5.2% and -0.1% respectively. The most significant decrease in MIRs among males were liver (1.9 to 1.0), stomach (1.3 to 0.8) and lung (1.7 to 1.2) cancers while among females, they were pancreas (3.4 to 1.3), liver (1.8 to 1.2) and stomach (1.5 to 0.8) cancers.ConclusionThe most common cancers were those associated with 'westernisation' of lifestyle. Our figures contrast with other Sub-Saharan Africa countries where infection related cancers are most predominant. The MNCR has also improved its data quality over time.     

纤细滇美龙(Dianmeisaurus gracilis Shang & Li,2015)新材料

根据一件产自云南罗平中三叠世关岭组Ⅱ段的新标本并结合产自相同地点和地层中的模式标本对纤细滇美龙(Dianmeisaurus gracilis Shang & Li,2015)进行了详细研究.原模式标本暴露其腹而,而新标本暴露其背面,两者互相补充提供了更完整、精确的纤细滇美龙解剖学信息.新材料揭示该种具有非常短小的吻部,眶前区的长度不仅短于眶后区长度,甚至短于眼眶的长度;外鼻孔小且位置靠前,即鼻孔前区的长度短于鼻孔后缘与眼眶前缘之间的距离;由两额骨构成的眼眶间隔非常狭窄,宽度小于顶骨平台宽度的1/3;额骨前后两端均具渐尖的突起;顶骨后部不收缩,顶骨平台后缘呈深V型.补充了新信息和包含更多属种(如Dawazisaurus)后的系统发育学分析支持了之前滇美龙和滇东龙互为姊妹群的结论,同时它们和马家山龙、滇肿龙、贵州龙和大洼子龙一起构成了一个仅由中国的属种组成的单系类群.与欧洲肿肋龙类群(Dactylosaurus,Anarosaurus,Serpianosaurus和Neusticosaurus)相比,这一单系类群与幻龙类有更近的亲缘关系.     

2015年武汉生物工程学院论文汇总表

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中国动物学会2015年活动计划

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纤细滇美龙(Dianmeisaurus gracilis Shang & Li,2015)新材料（英文）

根据一件产自云南罗平中三叠世关岭组II段的新标本并结合产自相同地点和地层中的模式标本对纤细滇美龙(Dianmeisaurus gracilis ShangLi,2015)进行了详细研究。原模式标本暴露其腹面,而新标本暴露其背面,两者互相补充提供了更完整、精确的纤细滇美龙解剖学信息。新材料揭示该种具有非常短小的吻部,眶前区的长度不仅短于眶后区长度,甚至短于眼眶的长度;外鼻孔小且位置靠前,即鼻孔前区的长度短于鼻孔后缘与眼眶前缘之间的距离;由两额骨构成的眼眶间隔非常狭窄,宽度小于顶骨平台宽度的1/3;额骨前后两端均具渐尖的突起;顶骨后部不收缩,顶骨平台后缘呈深V型。补充了新信息和包含更多属种(如Dawazisaurus)后的系统发育学分析支持了之前滇美龙和滇东龙互为姊妹群的结论,同时它们和马家山龙、滇肿龙、贵州龙和大洼子龙一起构成了一个仅由中国的属种组成的单系类群。与欧洲肿肋龙类群(Dactylosaurus,Anarosaurus,Serpianosaurus和Neusticosaurus)相比,这一单系类群与幻龙类有更近的亲缘关系。     

2015生物能源专刊序言

生物能源领域的研究和产业开发在近年得到了快速发展,呈现出系统性和多元性的趋势。2014年10月17–19日,第四届生物质能源技术国际会议-暨第八届国际生物能源会议(ICBT/WBS 2014)在长沙市举行。本次会议由中国可再生能源学会生物质能专业委员会、生物质能源产业技术创新战略联盟、欧洲生物质能产业协会、美国化学工程师学会和联合国开发计划署主办,由湖南省林业科学院和清华大学中国-巴西气候变化与能源技术创新研究中心承办。在会议优秀论文基础上,结合征稿出版了"生物能源"专刊。本专刊以综述和研究论文的形式介绍了国内在生物能源及相关领域的最新研究成果,包括生物质资源分析、预处理、燃料和化学品制备、副产品利用和策略研究等。     

National environmental footprints and planetary boundaries: from methodology to policy implementation 59th LCA forum,Swiss Federal Institute of Technology,Zürich,June 12, 2015

The 59th LCA forum was held on 12 June, 2015 to discuss the situation with regard to national environmental footprints and their relation to planetary boundaries and to the global carrying capacity. This conference report presents the highlights of the LCA forum. Several approaches of how to quantify a safe operating space of the Earth were presented, such as the planetary boundary concept published by Rockström et al. (Nature 462:472–475, 2009) and the ecological footprint (Bastianoni et al. 2013). Several presenters showed how they transformed environmental planetary boundaries to national and per capita allowances. In a research project funded by the Swiss Federal Office for the Environment safe and unsafe areas were determined by combining the level of overshoot, the level of confidence in the information and the trend in the environmental load. The areas of climate change, biodiversity losses and nitrogen losses show a large overshoot on a global level but also from the point of view of Swiss consumption. Other organizations use the planetary boundary concept to identify companies which qualify for environmentally sustainable funds. Finally, life cycle impact assessment methods are being developed using the planetary boundary concept. The weighting step is based on the level of overshoot, which is close to “distance to target” approaches. It was discussed that the nine planetary boundaries face some consistency and operationalisation problems. For instance, land use changes cause biodiversity losses, which is a planetary boundary parameter in its own. Chemical pollution on the other hand is a general topic, for which a quantification approach has to be developed first (load as well as its planetary boundary). The discussion forum showed that individual countries and political entities like the European Union start monitoring their consumption based environmental footprint. Within this context, approaches and concepts are needed to define the environmentally safe operating space. The LCA forum showed that there is still basic research needed to reliably and consistently quantify relevant planetary boundaries (avoiding overlapping indicators) and to transfer these boundaries to per capita allowances.     

Spatial patterns of landscape change in the Three Rivers Headwaters Region of China, 1987–2015

The Three Rivers Headwaters Region is one of the most import ecological protection regions and Tibetan inhabited regions in China. Located in the Qinghai province of China, the Region is the source of the Yangtze, the Yellow and the Lantsang-Mekong Rivers. This study region was based on remote sensing imagery. An ecological landscape classification of the area is presented, as well as a suite of landscape indices for landscape pattern changes from 1987 to 2015. The influence of human activities on the landscape change of study area is discussed. The results showed landscape structure complexity, fragmentation gradually increased, while the indices of contagion and evenness were decreased. Structure characteristic of landscape change in this region are more obvious, especially, the difference in space distributions of part and the whole. There were trend of uniform distribution of different types and diversity gradually increased in the source of Yangtze River. And an opposite tendency is showing in the Yellow River and Lantsang-Mekong River. Physical-geographical conditions, climate change and government policy at study period were the main reasons of significant landscape pattern change. This study proposes management measures for sustainable development in the Three Rivers Headwaters Region.