共查询到20条相似文献,搜索用时 156 毫秒
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Catron T Mendiola MA Smith SM Born J Walker MK 《Biochemical and biophysical research communications》2001,282(2):602-607
The aryl hydrocarbon receptor nuclear translocator (Arnt) and hypoxia-inducible factor (HIF)-1alpha mediate cellular responses to hypoxia. We investigated the ability of hypoxia to regulate Arnt and HIF-1alpha mRNA in the heart in vivo. We cloned avian Arnt, developed an in vivo model of chronic cardiac hypoxia, and measured expression of cardiac Arnt and HIF-1alpha mRNA by quantitative RT-PCR. Chronic hypoxic exposure (24 h to 15% O(2)) of day 9 chick embryos resulted in a 30-fold increase in covalent binding of (3)H-misonidazole, a hypoxic tissue marker, to cardiac tissue, and a 2-fold induction of cardiac inducible nitric oxide synthase mRNA, compared to normoxic controls. In this same model, cardiac Arnt mRNA expression decreased by 35%, while HIF-1alpha mRNA expression increased 400%. These data suggest that regulation of Arnt and HIF-1alpha mRNA expression may contribute to the physiological responses of the heart during prolonged hypoxia. 相似文献
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Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha 总被引:12,自引:0,他引:12
Gothié E Richard DE Berra E Pagès G Pouysségur J 《The Journal of biological chemistry》2000,275(10):6922-6927
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Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS 总被引:2,自引:0,他引:2
Yamashita T Ohneda O Nagano M Iemitsu M Makino Y Tanaka H Miyauchi T Goto K Ohneda K Fujii-Kuriyama Y Poellinger L Yamamoto M 《Molecular and cellular biology》2008,28(4):1285-1297
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Makino Y Uenishi R Okamoto K Isoe T Hosono O Tanaka H Kanopka A Poellinger L Haneda M Morimoto C 《The Journal of biological chemistry》2007,282(19):14073-14082
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Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway 总被引:40,自引:0,他引:40
Kallio PJ Wilson WJ O'Brien S Makino Y Poellinger L 《The Journal of biological chemistry》1999,274(10):6519-6525
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