共查询到20条相似文献,搜索用时 15 毫秒
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Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells. 总被引:21,自引:5,他引:16
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H B Shu A B Agranoff E G Nabel K Leung C S Duckett A S Neish T Collins G J Nabel 《Molecular and cellular biology》1993,13(10):6283-6289
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Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation. 总被引:10,自引:3,他引:7
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N Arima J A Molitor M R Smith J H Kim Y Daitoku W C Greene 《Journal of virology》1991,65(12):6892-6899
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Activation of the human immunodeficiency virus long terminal repeat by herpes simplex virus type 1 is associated with induction of a nuclear factor that binds to the NF-kappa B/core enhancer sequence. 总被引:17,自引:9,他引:8
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J M Gimble E Duh J M Ostrove H E Gendelman E E Max A B Rabson 《Journal of virology》1988,62(11):4104-4112
It has been previously shown that herpes simplex virus type 1 (HSV-1) infection of HeLa cells results in augmentation of gene expression directed by the human immunodeficiency virus (HIV) long terminal repeat (LTR). This effect is presumably mediated by protein interactions with the LTR. We have used two different assays of DNA-protein interactions to study the HSV-induced activation of the HIV LTR. Activation of the HIV LTR is associated with increased protein binding to LTR sequences in a region including the NF-kappa B/core enhancer and the Sp1 binding sequences as monitored by an exonuclease protection assay. Gel retardation assays demonstrated that HSV-1 infection resulted in the induction of a nuclear factor(s) that binds to the NF-kappa B/core enhancer sequence. In addition to the activation of the HIV LTR, HSV induction of NF-kappa B activity may be important for the regulation of HSV gene expression during a herpesvirus infection. 相似文献
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N Nomura M J Zhao T Nagase T Maekawa R Ishizaki S Tabata S Ishii 《The Journal of biological chemistry》1991,266(13):8590-8594
At least two different types of proteins, NF-kappa B/KBF1 and HIV-EP1/PRDII-BF1/MBP-1, which are members of a family of rel oncoproteins and metal-finger proteins, respectively, bind to the human immunodeficiency virus type (HIV-1) enhancer. As a new member of a HIV-EP1 family that is expressed at a high level in T cells, we have isolated cDNA clones of HIV-EP2 by cross-hybridization with HIV-EP1 cDNA. HIV-EP2 protein consists of 1,833 amino acids and has a molecular weight of 211,000. HIV-EP2 protein is highly homologous with HIV-EP1/PRDII-BF1/MBP-1 in three regions. These three regions contain the potential nuclear localization signal followed by a Ser/Thr-rich region, the DNA-binding domain consisting of a metal-finger structure, and a cluster of acidic amino acids. The DNA-binding property of HIV-EP2 was similar to that of HIV-EP1. Northern blot analysis of HIV-EP2 mRNA indicated relatively high expression in the T cell line Molt-4 and in some tumor cell lines. Furthermore, like HIV-EP1, expression of HIV-EP2 mRNA was greatly induced by mitogen and phorbol ester treatment of Jurkat T cells, suggesting that HIV-EP2 acts in HIV production from latently infected T cells. 相似文献
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Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56,419 completely sequenced and manually annotated full-length cDNAs
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Takeda J Suzuki Y Nakao M Barrero RA Koyanagi KO Jin L Motono C Hata H Isogai T Nagai K Otsuki T Kuryshev V Shionyu M Yura K Go M Thierry-Mieg J Thierry-Mieg D Wiemann S Nomura N Sugano S Gojobori T Imanishi T 《Nucleic acids research》2006,34(14):3917-3928