Autoregulation of RNase III operon by mRNA processing. |
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| Authors: | J C Bardwell P Régnier S M Chen Y Nakamura M Grunberg-Manago and D L Court |
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| Affiliation: | Laboratory of Chromosome Biology, Frederick Cancer Research Facility, MD 21701. |
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| Abstract: | RNase III has been implicated in the control of gene expression by the processing of mRNA. We have found that the rnc operon is autoregulated; rnc- mutant strains oversynthesize the operon's mRNA and protein products. A site in the 5'-noncoding region of the operon's message is cleaved by RNase III. This site-specific cleavage appears to be the initial step in the functional inactivation of the message, since the half-life of the cut message is dramatically shorter than that of the uncut message. |
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