Characterization and application of porous gold nanoparticles as 2‐photon luminescence imaging agents: 20‐fold brighter than gold nanorods |
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| Authors: | Joo H Park Jisoo Park Suho Kim Se‐Hwa Kim Tae G Lee Jae Y Lee Jung‐Sub Wi |
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| Affiliation: | 1. Center for Optical Metrology, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea;2. Center for Nano‐Bio Measurement, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea |
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| Abstract: | Two‐photon nonlinear microscopy with the aid of plasmonic contrast agents is an attractive bioimaging technique capable of generating high‐resolution images in 3 dimensions and facilitating targeted imaging with deep tissue penetration. In this work, physically synthesized gold nanoparticles containing multiple nanopores are used as 2‐photon contrast agents and are reported to emit a 20‐fold brighter 2‐photon luminescence as compared to typical contrast agents, that is, gold nanorods. A successful application of our porous gold nanoparticles is experimentally demonstrated by in vitro nonlinear optical imaging of adipocytes at subcellular level.  |
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| Keywords: | gold nanorods luminescence plasmonic porous nanoparticles 2‐photon |
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