Fluorescent sensors based on quinoline‐containing styrylcyanine: determination of ferric ions,hydrogen peroxide,and glucose,pH‐sensitive properties and bioimaging |
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| Authors: | Xiaodong Yang Peiliang Zhao Jinqing Qu Ruiyuan Liu |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, P.R. China;2. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P.R. China |
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| Abstract: | A novel styrylcyanine‐based fluorescent probe 1 was designed and synthesized via facile methods. Ferric ions quenched the fluorescence of probe 1, whereas the addition of ferrous ions led to only small changes in the fluorescence signal. When hydrogen peroxide was introduced into the solution containing probe 1 and Fe2+, Fe2+ was oxidized to Fe3+, resulting in the quenching of the fluorescence. The probe 1/Fe2+ solution fluorescence could also be quenched by H2O2 released from glucose oxidation by glucose oxidase (GOD), which means that probe 1/Fe2+ platform could be used to detect glucose. Probe 1 is fluorescent in basic and neutral media but almost non‐fluorescent in strong acidic environments. Such behaviour enables it to work as a fluorescent pH sensor in both the solution and solid states and as a chemosensor for detecting volatile organic compounds with high acidity and basicity. Subsequently, the fluorescence microscopic images of probe 1 in live cells and in zebrafish were achieved successfully, suggesting that the probe has good cell membrane permeability and a potential application for imaging in living cells and living organisms. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | bioimaging ferric ions fluorescent sensor hydrogen peroxide pH sensitive quinoline |
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