Starvation survival response of Mycobacterium tuberculosis |
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| Authors: | Parish Tanya |
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| Affiliation: | Department of Medical Microbiology, Barts and the London, Queen Mary's School of Medicine and Dentistry, London E1 2AD, United Kingdom. t.parish@qmul.ac.uk |
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| Abstract: | The ability of Mycobacterium tuberculosis auxotrophs to survive long-term starvation was measured. Tryptophan and histidine auxotrophs did not survive single-amino-acid starvation, whereas a proline auxotroph did. All three auxotrophs survived complete starvation. THP-1 cells were also able to restrict the growth of the tryptophan and histidine auxotrophs. |
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