| 阿里红多糖对小鼠抗疲劳和耐缺氧的作用* |
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| 引用本文： | 沙爱龙,郝海燕.阿里红多糖对小鼠抗疲劳和耐缺氧的作用*[J].中国应用生理学杂志,2019,35(5):418-421. |
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| 作者姓名： | 沙爱龙 郝海燕 |
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| 作者单位： | 1. 重庆三峡学院教师教育学院, 重庆 404100;
2. 西南医科大学基础医学院生理学教研室, 四川 泸州 646000;
3. 重庆三峡学院环境与化学工程学院, 三峡库区水环境演变与污染防治重庆市重点实验室, 重庆 404100 |
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| 基金项目： | 四川省教育厅科研计划项目(18ZB0636,17ZB0469);重庆三峡学院人才引进科研启动金项目;四川省卫计委课题(16PJ541) |
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| 摘 要： | 目的:研究阿里红多糖对小鼠的抗疲劳和耐缺氧作用。方法:将48只小鼠随机分为4组(n=12),即对照组,低、中、高剂量阿里红多糖组(100、200、400 mg/kg)。各组小鼠按0.20 ml/10 g每日连续灌胃21 d后,观察不同剂量的阿里红多糖对小鼠负重游泳时间,运动后血清尿素氮、血乳酸、肝糖原、肌糖原含量和常压耐缺氧存活时间、断头后呼吸维持时间的影响。结果:与对照组相比,阿里红多糖能延长小鼠负重游泳时间、耐缺氧存活时间及断头后呼吸维持时间,其中中、高剂量组差异均极显著(P＜0.01),低剂量组差异显著(P＜0.05);阿里红多糖能降低运动小鼠血清尿素氮、血乳酸含量,增加运动小鼠肝糖原、肌糖原含量,且大都差异显著(P＜0.05)或极显著(P＜ 0.01)。结论:阿里红多糖具有抗疲劳作用和提高耐缺氧能力作用。
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| 关 键 词： | 阿里红多糖 抗疲劳 耐缺氧 小鼠 |
| 收稿时间： | 2019-02-28 |
Effects of the Fomes officinalis Ames. polysaccharides on anti-fatigue and hypoxia tolerance in mice |
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| SHA Ai-long,HAO Hai-yan.Effects of the Fomes officinalis Ames. polysaccharides on anti-fatigue and hypoxia tolerance in mice[J].Chinese Journal of Applied Physiology,2019,35(5):418-421. |
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| Authors: | SHA Ai-long HAO Hai-yan |
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| Affiliation: | 1. School of Teacher Education, Chongqing Three Gorges University, Chongqing 404100;
2. Department of Physiology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000;
3. School of Environmental and Chemical Engineering, Chongqing Key Laboratory of Water Environment Evolution and Pollution Control in Three Gorges Reservoir Area, Chongqing Three Gorges University, Wanzhou 404100, China |
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| Abstract: | Objective: To study the effects of Fomes officinalis Ames. polysaccharides(FOPS) on anti-fatigue and hypoxia tolerance in mice. Methods: Forty-eight mice were randomly divided into control group, low-dose, middle-dose and high-dose group of FOPS (100, 200, 400 mg/kg). All mice were orally administered by 0.20 ml/10 g, once a day for 21 consecutive days. The effects of different doses of FOPS on the loaded-swimming time, the content of serum urea nitrogen, the blood lactic acid, the hepatic glycogen and the muscle glycogen after exercise, the survival time under hypoxia at normal pressure and the maintenance time after decapitation were observed. Results: FOPS could significantly prolong the loaded-swimming time, decrease the contents of serum urea nitrogen , blood lactic acid and increase the contents of hepatic glycogen and muscle glycogen, significantly prolong the survival time under hypoxia and the maintenance time after decapitation comparing with the control group. Compared with the control group, FOPS could prolong the weight-bearing swimming time, anti-hypoxia survival time and respiratory maintenance time of mice after decapitation in a dose-dependent manner (P＜0.05 or 0.01). FOPS could decrease the contents of serum urea nitrogen and blood lactic acid, and increase the contents of hepatic glycogen and muscle glycogen in exercise mice, and most of them were significantly different (P＜0.05) or extremely significant (P＜0.01). Conclusion: FOPS has anti-fatigue effects and can improve hypoxia tolerance. |
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| Keywords: | Fomes officinalis Ames polysaccharides anti-fatigue hypoxia tolerance mice |
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