Antibacterial Δ1‐3‐Ketosteroids from the South China Sea Gorgonian Coral Subergorgia rubra |
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| Authors: | Chang‐Lun Shao Mei Wang Xiu‐Li Zhang Chang‐Yun Wang |
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| Affiliation: | 1. Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.?R. China, (phone: +86‐532‐82031536;2. fax: +86‐532‐82031536 ext. 266003) |
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| Abstract: | Three new Δ1‐3‐ketosteroids characterized with a 9‐OH, subergosterones A–C ( 1 – 3 ), together with five known analogs 4 – 8 , were obtained from the gorgonian coral Subergorgia rubra collected from the South China Sea. The structures of 1 – 3 , including their absolute configurations, were determined by comprehensive spectroscopic methods and electronic circular dichroism (ECD) experiments. Compounds 2 and 3 exhibited inhibitory antibacterial activities against Bacillus cereus with MIC values of 1.56 μM . |
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| Keywords: | Subergorgia rubra Subergosterones A – C Gorgonian Δ 1‐3‐Ketosteroid Antibacterial activity |
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