E‐Cadherin,CD44v6, and Insulin‐Like Growth Factor‐II mRNA‐Binding Protein 3 Expressions in Different Stages of Hydatidiform Moles |
| |
| Authors: | Jiajun Wang Min Zhao Jianping Xiao Man Wu Yaohua Song Yongxiang Yin |
| |
| Affiliation: | 1. Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou, People's Republic of China;2. Department of Gynecology, The Affiliated Maternity and Child Health Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, People's Republic of China;3. Department of Prenatal Diagnosis Center, The Affiliated Maternity and Child Health Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, People's Republic of China;4. Department of Pathology, The Affiliated Maternity and Child Health Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, People's Republic of China |
| |
| Abstract: | E‐cadherin, CD44v6, and IMP3 expression in partial, complete, and invasive hydatidiform moles (HMs) was evaluated. High E‐cadherin expression with low CD44v6 expression was observed in partial, complete, and invasive HMs, as well as in normal placental tissues; and there was no significant difference in E‐cadherin and CD44v6 expression among the four groups. However, IMP3 expression was gradually decreased in the order of normal placental tissues, partial HMs, complete HMs, and invasive HMs; wherein, invasive HMs had the lowest level. Low IMP3 expression may serve as a prognostic biomarker for HMs, and IMP3 may play a certain role in HMs progression. |
| |
| Keywords: | E‐Cadherin CD44v6 IMP3 Hydatidiform Mole |
|
|
