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细胞凋亡中的Bcl-2家族蛋白及其BH3结构域的功能研究
引用本文:柳向军,张令强,刘小林,贺福初.细胞凋亡中的Bcl-2家族蛋白及其BH3结构域的功能研究[J].生物化学与生物物理进展,2006,33(3):221-225.
作者姓名:柳向军  张令强  刘小林  贺福初
作者单位:1. 军事医学科学院放射与辐射医学研究所,北京,100850;西北农林科技大学动物科技学院,杨凌,712100
2. 军事医学科学院放射与辐射医学研究所,北京,100850
3. 西北农林科技大学动物科技学院,杨凌,712100
基金项目:国家自然科学基金资助项目(30200043,30321003),国家高技术研究发展计划(863)资助项目(2004AA221100,2002BA71A02-5)~~
摘    要:凋亡相关蛋白中的Bcl-2家族是细胞凋亡的关键调节分子,由抗凋亡和促凋亡成员组成,这些成员之间通过相互协同作用调节了线粒体结构与功能的稳定性,从而在线粒体水平发挥着细胞凋亡的“开关”作用.抗凋亡成员大都分布于线粒体的外膜,与促凋亡成员的BH3结构域相互作用对细胞凋亡发挥抵抗作用.促凋亡成员则主要分布于细胞浆中,细胞接受死亡信号刺激后,促凋亡成员自身受到一系列的调节,如典型的Bax构象改变、BAD和Bik的磷酸化调节以及Bid和Bim的蛋白裂解效应等,使得促凋亡成员在凋亡信号的刺激下整合于线粒体外膜,最终导致线粒体通透转换孔的开放,进而释放包括细胞色素c、凋亡诱导因子、Smac等重要的凋亡因子,随后caspase被激活进而断裂重要的细胞内结构蛋白与功能分子,执行细胞凋亡.

关 键 词:Bcl-2家族  BH3结构域  细胞凋亡  线粒体  细胞色素c
收稿时间:2005-09-29
修稿时间:2005-09-292005-11-01

Role for The Bcl-2 Family Proteins and BH3 Domain in Apoptosis
LIU Xiang-Jun,ZHANG Ling-Qiang,LIU Xiao-Lin and HE Fu-Chu.Role for The Bcl-2 Family Proteins and BH3 Domain in Apoptosis[J].Progress In Biochemistry and Biophysics,2006,33(3):221-225.
Authors:LIU Xiang-Jun  ZHANG Ling-Qiang  LIU Xiao-Lin and HE Fu-Chu
Abstract:Apoptosis action is primarily exerted at the level of mitochondira, in which Bcl-2 family of proteins play an important role in its regulation. Bcl-2 family consists of anti-apoptotic and pro-apoptotic members. The anti-apoptotic members usually exist in the outer mitochondrial membrane and inhibit cell death via interaction with pro-apoptotic counterparts BH3 domain. Pro-apoptotic members are commonly localize in the cytoplasm. A series of events occured, such as typical Bax conformational change, BAD and Bik phosphorylation as well as Bid and Bim proteolysis in response to several death stimuli. As a result, these pro-apoptotic proteins directly integrate to the outer mitochondrial membranes. Finally, mitochondrial permeability transition pore is opened, by followed the release of apoptogenic factors from the mitochondrial intermembrane space, including cytochrome c, apoptosis inducing factor(AIF) and Smac, then the activation of downstream caspases and execution of cell death.
Keywords:Bcl-2 family  BH3 daomain  apoptosis  mitochondria  cytocrome c  
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