首页 | 官方网站   微博 | 高级检索  
     

线粒体,活性氧和细胞凋亡
引用本文:赵云罡,徐建兴.线粒体,活性氧和细胞凋亡[J].生物化学与生物物理进展,2001,28(2):168-171.
作者姓名:赵云罡  徐建兴
作者单位:中国科学院生物物理研究所,北京 100101
摘    要:在能量代谢和自由基代谢中,线粒体均占据着十分重要的地位.通过呼吸链电子漏途径,线粒体产生大量超氧阴离子,并通过链式反应形成对机体有损伤作用的活性氧.通过呼吸链电子漏,氧化磷酸化解偶联,线粒体内膜产生通透性转变孔道(PTP)及Box-和/或PTP-介导的细胞色素c向胞质的转移等种种因素,线粒体参与一般抗氧化防御及细胞凋亡等重要生理过程的调控.在与线粒体相关的细胞凋亡中,活性氧的信号作用是十分明显的.

关 键 词:线粒体,活性氧,细胞凋亡,电子漏,细胞色素c
收稿时间:2000/4/29 0:00:00
修稿时间:6/7/2000 12:00:00 AM

Mitochondria, Reactive Oxygen Species and Apoptosis
ZHAO Yun-Gang and XU Jian-Xing.Mitochondria, Reactive Oxygen Species and Apoptosis[J].Progress In Biochemistry and Biophysics,2001,28(2):168-171.
Authors:ZHAO Yun-Gang and XU Jian-Xing
Affiliation:Institude of Biophysics, The Chinese Academy of Sciences, Beijing100101, China;Institude of Biophysics, The Chinese Academy of Sciences, Beijing100101, China
Abstract:Mitochondria are involved not only in energy metabolism but also in free radical metabolism. Superoxide anion can be generated through a way of electron leak of respiratory chain and the reactive oxygen species (ROS) can be formed in the further reactions of O2-· in mitochondria. The role of mitochondria in anti-oxidant functions and cell apoptosis is discussed in terms of electron leak of respiratory chain, uncoupling of oxidative phosphorelation, mitochondrial pore, Box- or/and PTP-mediated release of cytochrome c from mitochondria and so on. The signaling act of ROS is emphasized in the regulation of cell apoptosis.
Keywords:mitochondria  reactive oxygen species  apoptosis  electron leak  cytochrome c  
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《生物化学与生物物理进展》浏览原始摘要信息
点击此处可从《生物化学与生物物理进展》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司    京ICP备09084417号-23

京公网安备 11010802026262号