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| 用毛细管电泳技术对北京汉族人群9个STR基因座遗传多态性的研究 | |
| 引用本文： | 裴黎,王俭,季安全,荣辽江,王海生,邓华.用毛细管电泳技术对北京汉族人群9个STR基因座遗传多态性的研究[J].生物化学与生物物理进展,2003,30(1):147-150. |
| 作者姓名： | 裴黎 王俭 季安全 荣辽江 王海生 邓华 |
| 作者单位： | 1. 公安部第二研究所,北京,100038 2. 内蒙古自治区公安厅,呼和浩特,010051 3. 湖北省公安厅,武汉,430070 |
| 摘 要： | 为对北京汉族D3S1358、vWA、FGA、D8S1179、D21S11、D18S51、D5S818、D13S317及D7S820等9个STR基因座的遗传多态性进行群体遗传学研究，利用荧光标记复合扩增及毛细管电泳自动荧光检测的方法，对236名无关个体获得9个STR基因座等位基因的分布频率，结果均符合Hardy-Weinberg平衡.计算了各基因座的杂合度（H）、个人识别能力（DP）、偶合率（PM）、非父排除率（EPP）和多态性信息总量（PIC）等群体遗传学数据.结果表明，这9个STR基因座多态性好，灵敏度高，可用于人类遗传分析及法医学中的亲子鉴定和个人识别. |
| 关 键 词： | 毛细管电泳，短串联重复序列（STR），复合扩增，群体遗传学 |
| 收稿时间： | 2002/8/15 0:00:00 |
| 修稿时间： | 2002年8月15日 |
A Study Using Capiliary Electrophoresis in Genetic Polymorphism of 9 STR Loci in Han Population of Beijing |
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| PEI Li,WANG Jian,JI An-Quan,RONG Liao-Jiang,WANG Hai-Sheng and DENG Hua.A Study Using Capiliary Electrophoresis in Genetic Polymorphism of 9 STR Loci in Han Population of Beijing[J].Progress In Biochemistry and Biophysics,2003,30(1):147-150. | |
| Authors: | PEI Li WANG Jian JI An-Quan RONG Liao-Jiang WANG Hai-Sheng and DENG Hua |
| Affiliation: | Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China;Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China;Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China;Bureau of NeiMengGu Public Security, Huhehaote 010051, China;Institute of Forensic Science and Technology, Bureau of Hubei Public Security, Wuhan 430070, China;Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China |
| Abstract: | Totally 236 unrelated individuals from majority population of Han Chinese in Beijing have been inspected with 9 polymorphism STR loci D3S1358,vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317,D7S820 by means of capillary electrophoresis and fluorescence multiple amplification. The results indicated a good correspondence with the Hardy-Weinberg equilibrium. Observed heterozygosity, expected heterozygosity,DP,PM,EPP,and PIC were calculated for evaluation of forensic application. |
| Keywords: | capillary electrophoresis short tandem repeat multiplex amplification population genetics |
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